Session Name: Poster Session C: Kidney Psychosocial
Session Type: Poster Session
Date: Saturday, May 30, 2020
Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
*Purpose: To evaluate the reliability and validity of the PROMIS Depression computerized adaptive test (PROMIS-D CAT) in relation to a legacy measure in adult Kidney Transplant Recipients (KTR).
*Methods: A cross-sectional sample of adult outpatient KTR completed the PROMIS-D CAT and Patient Health Questionnaire (PHQ-9) on an electronic data capture platform. Socio-demographic and relevant clinical data was also collected from medical records. Construct validity was assessed using Spearman’s Rho and known groups comparisons; test-retest reliability using intra-class correlation (ICC). Receiver operating characteristics (ROC) analysis was used to assess discrimination of PROMIS-D CAT using an established cut-off on the PHQ-9 (≥10) for moderate/severe depression. The PROMIS-D CAT cut-off for moderate/severe depression was identified using the Youden Index.
*Results: Mean (SD) age of the 156 participants was 50 (16) years, mean (SD) CKD-EPI eGFR was 54 (22), 67% male and 64% Caucasian. Median (IQR) time since transplant was 8.5 (3.4-13.8) years. Based on the PHQ-9, 17% reported moderate/severe depression. The PROMIS-D CAT and the PHQ-9 (r=0.59) were moderately correlated. Test-retest reliability was good (ICC=0.73). Mean (SD) PROMIS-D CAT scores were higher for patients with a Charlson Comorbidity Index ≥ 4 compared to <3 (51(7) vs 48(8); p=0.07) and patients with eGFR <30 compared to >60 (52(8) vs 49(9), p=0.07). Patients from minority groups had higher PROMIS-D CAT scores compared to Caucasians (51(8) vs 48(8); p<0.05). ROC analysis suggested excellent discrimination with an area under the curve of 0.91 (95% CI: 0.85-0.97). The Youden Index identified cut-off for moderate/severe depression for the PROMIS-D CAT was 54 (Sensitivity: 88%, specificity: 82%, positive predictive value: 0.5, negative predictive value: 0.97).
*Conclusions: These results provide new evidence of the validity and reliability of PROMIS-D CAT in KTR and support its use in research and care. In addition, a previously-calculated crosswalk between the PHQ-9 and PROMIS-D CAT allows for easy conversion among centers using the PHQ-9.
To cite this abstract in AMA style:Shah V, Rezaeishahreza A, Lui E, Aser R, Bartlett S, Li M, Howell D, Peipert J, Novak M, Mucsi I. Validation of Patient Reported Outcomes Measurement Information System (PROMIS) Computer Adaptive Testing Depression Item Bank in Kidney Transplant Recipients [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/validation-of-patient-reported-outcomes-measurement-information-system-promis-computer-adaptive-testing-depression-item-bank-in-kidney-transplant-recipients/. Accessed December 6, 2023.
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