Am J Transplant, Volume 20, Suppl 3 Archives - ATC Abstracts

2020 American Transplant Congress
HLA-DR/DQ Molecular Mismatch Dictates Early Risk of De Novo Donor-Specific Antibody Development and Offers a Personalized Approach to Immunosuppression Management in Kidney Transplantation
S. Davis¹, C. Wiebe², K. Campbell¹, C. Anobile³, M. Aubrey³, A. Wiseman¹, E. Pomfret¹, P. Nickerson², J. Cooper¹
¹University of Colorado, Aurora, CO, ²University of Manitoba, Winnipeg, MB, Canada, ³Clinimmune, Aurora, CO
*Purpose: Clinicians have few tools to predict the risk of alloimmune injury in a patient undergoing renal transplantation, as traditional demographic or clinical variables lack…
2020 American Transplant Congress
TRANSFORM Study (NCT01950819): Application of the Ibox Clinical Trial Simulation Tool to Project Long-Term Kidney Allograft Outcome
G. Divard¹, O. Aubert¹, M. Raynaud¹, J. Pascual², F. Vincenti³, P. Bernhardt⁴, C. Legendre¹, A. Loupy¹, .. on behalf of TRANSFORM Investigators⁵
¹INSERM U970, Paris Transplant Group, Paris, France, ²Department of Nephrology, Hospital del Mar/Universitat Autònoma de Barcelona, Barcelona, Spain, ³Department of Surgery/Kidney Transplant Service, University of California, San Francisco, CA, ⁴Research and Development, Novartis Pharma AG, Basel, Switzerland, ⁵TRANSFORM Investigators, Basel, Switzerland
*Purpose: The development of pharmaceutical agents in transplantation is currently limited by long waits for hard endpoints. We sought to use a risk stratification system…
2020 American Transplant Congress
Your Path to Transplant Tailored Education Increases Living Donation Transplant Actions and Wait-Listing Rates: Final Randomized Controlled Trial Findings
A. Waterman¹, Y. Cui², J. L. Beaumont², J. D. Peipert³, A. Paiva⁴, M. L. Robbins⁴
¹Transplant Research and Education Center, Los Angeles, CA, ²Terasaki Research Institute, Los Angeles, CA, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Department of Psychology, University of Rhode Island, Kingston, RI
*Purpose: Tailoring education and behavior change interventions to address gaps in individual patients’ knowledge, readiness, and socio-economic challenges may help more end-stage kidney disease patients…
2020 American Transplant Congress
Prognostic Index of Circulating Tumor Cells for Tumor Recurrence in Patients with Hepatocellular Carcinoma after Liver Transplantation
M. Chen¹, Z. Chen¹, X. Lin², W. Ju¹, X. He¹
¹Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Division of General Surgery, The Eastern Hospital of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Liver transplantation (LT) is an effective option for hepatocellular carcinoma (HCC) and end-stage liver cirrhosis. However, organ shortage and tumor recurrence are the main…
2020 American Transplant Congress
A Prospective Randomized Multicenter Trial (BEST Trial) of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression: Infectious Complications
P. West-Thielke¹, A. Shields², D. Kaufman³, J. Leone⁴, A. Wiseman⁵, A. Matas⁶, T. Sa⁷, E. King⁷, R. Alloway², S. Woodle²
¹University of Illinois, Chicago, IL, ²University of Cincinnati, Cincinnati, OH, ³University of Wisconsin, Madison, IL, ⁴Tampa General Hospital, Tampa, FL, ⁵University of Colorado, Aurora, CO, ⁶University of Minnesota, Minneapolis, MN, ⁷Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: The BEST Trial (Belatacept-based Early Steroid Withdrawal Trial) is a prospective, randomized, multi-center trial designed to compare two belatacept (BELA)-based calcineurin inhibitor-free (CNI), early…
2020 American Transplant Congress
Care Processes and Structures Associated with Higher Medication Adherence: The Positive Adherence Study
A. Dabirzadeh¹, B. Foster¹, M. Dahhou¹, S. Mital²
¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Hospital for Sick Children, Toronto, ON, Canada
*Purpose: We aimed to identify care processes and structures that are independently associated with higher medication adherence among adolescent and young adult transplant recipients.*Methods: We…
2020 American Transplant Congress
Trends in Intestinal and Multivisceral Transplantation in the United States over 30 Years
M. L. Samoylova¹, J. Yerxa¹, B. I. Shaw¹, S. Horslen², S. Jafri³, A. Mavis⁴, T. Schiano⁵, B. Summers⁶, A. S. Barbas¹, D. L. Sudan¹, M. C. Segovia⁴
¹Surgery, Duke University Hospital, Durham, NC, ²Ped Gastroenterology, Seattle Childrens' Hospital, Seattle, WA, ³Gastroenterology, Henry Ford Hospital, Detroit, MI, ⁴Gastroenterology, Duke University Hospital, Durham, NC, ⁵Gastroenterology, Mt Sinai Hospital, New York, NY, ⁶Transplant Pharmacy, Henry Ford Hospital, Detroit, MI
*Purpose: We describe trends in intestinal transplantation use and outcomes over time in the USA.*Methods: We use the cohort of intestinal and multivisceral transplants 1990-2019…
2020 American Transplant Congress
Costimulation Blockade-Based Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model
R. Schmitz, Z. W. Fitch, P. M. Schroder, A. Y. Choi, M. Manook, J. Yoon, J. Kwun, S. J. Knechtle
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Sensitized transplant recipients represent a challenging population in part due to the presence of donor-specific antibodies (DSA), which increase the risk of antibody-mediated rejection.…
2020 American Transplant Congress
Impact on Graft Histology of Steroid Withdrawal versus Standard Immunosuppression: Randomized, Parallel Group, Controlled Clinical Trial in Low Immunological Risk Kidney Transplant Patients
E. Gutiérrez Vílchez¹, T. Vázquez¹, V. López¹, M. León², E. Sola¹, J. Sellares³, M. Cobo⁴, J. Cruzado⁵, A. Torío⁶, J. Kanter⁷, P. Ruiz-Esteban¹, D. Hernández¹
¹Nephrology Service, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ²Pathology Department, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ³Nephrology Department, Hospital Vall de Hebron, Barcelona, Spain, ⁴Cardiology Department, Hospital Marqués de Valdecilla, Santander, Spain, ⁵Nephrology Department, Hospital de Bellvitge, Barcelona, Spain, ⁶Immunology, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ⁷Nephrology Department, Hospital Universitario Dr. Peset, Valencia, Spain
*Purpose: Steroid withdrawal can improve cardiovascular risk but little is known about its impact on graft histology and donor-specific antibodies.*Methods: 105 patients with a first…
2020 American Transplant Congress
Time for Change: Assessment of Renal Transplant Artery Stenosis with N.A.T.I.V.E. True-F.I.S.P. and N.A.T.I.V.E. G.R.E
J. C. Infante¹, A. Mattiazzi², M. Morsi³, G. Guerra², M. J. Defreitas⁴, J. Chandar⁴, L. J. Chen³, G. W. Burke³, J. Figueiro³, G. Ciancio³
¹Radiology, University of Miami, Miami, FL, ²Department of Medicine, Division of Nephrology, University of Miami / Miami Transplant Institute, Miami, FL, ³Department of Surgery, University of Miami / Miami Transplant Institute, Miami, FL, ⁴Department of Pediatrics, Division of Nephrology, University of Miami, Miami, FL
*Purpose: Non-contrast MRA can be fraught with artifact and lack of signal both in areas of stenosis as well as normal vessels. Therefore, it is…

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