Am J Transplant, Volume 20, Suppl 3 Archives - ATC Abstracts

2020 American Transplant Congress
Isolation of Preformed Antibodies from Whole Blood by Integrating Acoustics and Microfluidics in Sensitized Animal Model
J. Kwun¹, Y. Gu², M. Manook¹, M. Wu¹, J. Yoon¹, S. Knechtle¹, T. J. Huang²
¹Surgery, Duke University, Durham, NC, ²Mechanical Engineering and Material Science, Duke University, Durham, NC
*Purpose: Apheresis therapy refers to the separation, removal and/or exchange of unwanted blood components (red cells, white cells, platelets and/or plasma) by centrifugation and return…
2020 American Transplant Congress
Regulatory T Cell-Derived Amphiregulin Activates Fibroblasts to Promote Chronic Rejection after Heart Transplantation
L. Fan¹, X. Zhang¹, T. Li¹, L. R. Mathews¹, G. K. Dwyer², M. J. Calderon³, K. E. Helfrich³, M. A. Ross³, S. C. Watkins³, H. R. Turnquist¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Immunology, University of Pittsburgh, Pittsburgh, PA, ³Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA
*Purpose: Chronic rejection (CR) after organ transplantation (Tx) manifests as function-limiting allograft fibrosis and vasculopathy. Current immunosuppressants fail to prevent CR and insights into the…
2020 American Transplant Congress
Graphene Quantum Dots Prevent Glomerular and Interstitial Injury in Murine Adriamycin Nephropathy Through Macrophage Depletion
Y. Kim¹, K. Kim¹, J. Lee¹, J. Moon¹, J. Kim¹, J. Lee², Y. Kim¹, S. Yang¹
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Nephrology Clinic, National Cancer Center, Seoul, Korea, Republic of
*Purpose: Macrophage infilatration is a key feature of the pathogenicity associated with glomerular and tubulo-interstitial injury in kidney disease. Graphene quantum dots (GQDs) are considered…
2020 American Transplant Congress
Poly (ADP-Ribose) Polymerase Inhibitor Treatment Attenuated Renal Ischemia-Reperfusion Injury
H. Jang, K. Lee, J. Jeon, J. Lee, Y. Kim, D. Kim, W. Huh
Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of
*Purpose: Robust intrarenal inflammatory responses following ischemia-reperfusion injury (IRI) induce renal injury in ischemic acute kidney injury (AKI). We hypothesized that poly (ADP-Ribose) polymerase (PARP)…
2020 American Transplant Congress
2-Year Results of a Naturalistic Study of De Novo Extended-Release Tacrolimus Tablets vs. Tacrolimus Immediate-Release Capsules in Kidney Transplant Recipients
J. Hagopian¹, S. January¹, N. Nesselhauf¹, K. Progar¹, T. Horwedel², R. Delos Santos³
¹Barnes-Jewish Hospital, Saint Louis, MO, ²Veloxis Pharmaceuticals, Cary, NC, ³Washington University, Saint Louis, MO
*Purpose: In December 2015, our center instituted a protocol change moving to de novo use of tacrolimus-XR (LCPT). The objective of this extension study is…
2020 American Transplant Congress
Patient-Reported Outcomes in a Prospective Multicenter Trial of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression Regimens in Kidney Transplantation: A Prospective Analysis Across Two Years
J. M. Rohan¹, J. Leone², E. Woodle³, D. Kaufman⁴, A. Shields⁵, A. Wiseman⁶, A. Matas⁷, P. West-Thielke⁸, E. King⁵, R. Alloway³
¹Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA, ²Tampa General, Tampa, FL, ³University of Cincinnati, Cincinnati, OH, ⁴U Wisconsin, Madison, WI, ⁵U Cincinnati, Cincinnati, OH, ⁶U Colorado, Denver, CO, ⁷U Minnesota, Minneapolis, MN, ⁸UIC, Chicago, IL
*Purpose: Previous trials have not examined 2-year longitudinal differences in patient-reported outcomes (PRO) between belatacept (BELA)- and tacrolimus (TAC)-based therapies in adult kidney transplant (KTx)…
2020 American Transplant Congress
Survival Benefit of Accepting Kidneys from Older Donation after Cardiac Death Donors
S. Yu, J. Long, Y. Yu, M. Bowring, J. Motter, T. Ishaque, D. Segev, J. Garonzik-Wang, A. Massie
Johns Hopkins, Baltimore, MD
*Purpose: Kidneys from older donation after cardiac death (DCD) donors are less likely to be transplanted due to concerns about inferior post-transplant survival. But candidates…
2020 American Transplant Congress
Deceased Donors in Kidney Paired Donation
J. D. Kalbfleisch¹, W. Wang¹, M. A. Rees², A. B. Leichtman³, P. X. Song¹, V. Ashby¹, T. Shearon¹
¹Biostatistics, University of Michigan, Ann Arbor, MI, ²University of Toledo, Toledo, OH, ³University of Michigan, Ann Arbor, MI
*Purpose: A kidney paired donation pool (KPDP) consists of transplant candidates and their incompatible living donors along with nondirected living donors (NDDs). In a match…
2020 American Transplant Congress
Widespread Deregulation of Metabolic Genes in Steatotic Livers Pre- And Post-Transplantation
A. R. Wolen¹, C. Kuscu², C. Kuscu², A. Bajwa², J. Eason², S. Sataphaty³, J. D. Eason¹, D. Maluf¹, V. Mas¹
¹Department of Surgery_ University of Tennessee, James D Eason Transplant Institute, Memphis, TN, ²Department of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, ³Sandra Atlas Bass Center for Liver Diseases & Transplantation, Northshore University Hospital/Northwell Health, NYC, NY
*Purpose: The escalating obesity crisis is a double-edged sword for the field of liver transplantation; higher rates of fatty liver disease increase both the demand…
2020 American Transplant Congress
Comparative Analysis of Kidney Transplant-Specific versus Hospital-Wide Antibiograms
J. D. Lewis
Medical University of South Carolina, Charleston, SC
*Purpose: Solid organ transplant (SOT) recipients are more likely to develop antimicrobial-resistant infections versus the general population, but few transplant centers have developed SOT-specific antibiograms…

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