2019 American Transplant Congress
Intact Lymphatics Are Essential for Costimulation Blockade-Induced Lung Allograft Survival
*Purpose: Blocking lymphangiogenesis is thought to diminish immune responses to donor tissues. However, lung transplantation (Tx), which involves airway and vascular but not lymphatic anastomoses,…2019 American Transplant Congress
Depletional Induction Therapy in Non-Human Primates – Preclinical Modeling of Polyclonal Depletion with Rhesus-Specific ATG
*Purpose: Antithymocyte globulins (ATG) have been used in transplantation since the late 1960s to prevent and treat acute allograft rejection. Over the past decade, induction…2019 American Transplant Congress
Effects of Standard Drug Immunosuppression on Peripheral Transitional B Cells and Gene Expression in Non-Human Primates
*Purpose: Operationally tolerant renal transplant recipients exhibit an increased number of transitional B cells and an upregulation of selected B-cell associated genes in the periphery…2019 American Transplant Congress
Increasing Expression of B-cell Maturation Antigen during the Development of Recall Antibody Responses: A Prospective Pharmaceutical Target for B-cell Suppression?
Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: Our previous study found that B cell maturation antigen (BCMA) is increasingly expressed by B/plasma cells during the development of de novo alloantibody responses.…2019 American Transplant Congress
Deceased Donor Vascularized Abdominal Wall Allograft Procurement – Lessons Learned from Early Experiences
Abdominal Transplant Surgery, Duke University Medical Center, Durham, NC
*Purpose: Vascularized abdominal wall allografts (AWA), which protect solid organs in patients with loss of abdominal domain or extensive abdominal wall damage, remain an essential…2019 American Transplant Congress
Differential Regulation of Phosphokinases by Anti-HLA Class I and 11 Antibodies
*Purpose: Anti-HLA antibodies, both pre-formed and de novo are associated with worse graft survival. Glomerular endothelial cells are the targets for antibody mediated rejection. We…2019 American Transplant Congress
Perfluorocarbon (PFC) Solutions for Organ Preservation
University of Florida, Gainesville, FL
*Purpose: The current status of organ transplantation demands consideration of extended criteria (ECD) brain dead donors (DBD) as well as donation after circulatory death (DCD)…2019 American Transplant Congress
Graft TIM4 Deficiency Protects Liver from Ischemia Reperfusion Injury: From Mouse to Human
*Purpose: Liver ischemia-reperfusion injury (IRI) is a major risk factor for early graft dysfunction and rejection in orthotopic liver transplantation (OLT). We and others have…2019 American Transplant Congress
Insulin Treatment in Pancreas Donors on the Intensive Care is a Marker of Beta Cell Death as Evidenced by microRNA Data
University of Manchester, Manchester, United Kingdom
*Purpose: We showed in prior studies that donor insulin use on intensive care predicts early beta cell dysfunction in islet and solid pancreas transplantation. We…2019 American Transplant Congress
Use Of Perirenal Adipose Tissue As A Source Of Donor Cells Allowing Evaluation Of Endothelial Inflammation And Quality Of Expanded Criteria Kidneys
*Purpose: Use of expanded-criteria donor (ECD) kidneys is a perspective to overcome organ shortage. Age and donor-related co-morbidy factors are known to affect graft function…
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