Am J Transplant, Volume 19, Suppl 3 Archives - Page 98 of 214 - ATC Abstracts

2019 American Transplant Congress
Single Cell Analysis of Kidney Allograft Rejection
C. M. Castro-Rojas¹, K. M. Roskin², C. G. Moore², B. Abu Jawdeh³, N. Salomonis², R. R. Alloway⁴, E. Woodle⁴, D. A. Hildeman¹
¹Immunobiology, Cincinnati Children's Hospital, Cincinnati, OH, ²Biomedical Informatics, Cincinnati Children's Hospital, Cincinnati, OH, ³Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, ⁴Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH
*Purpose: Rejection therapies (corticosteroids and antilymphocyte globulins) have not changed in over 50 years. In part this is due to a knowledge deficit of signaling…
2019 American Transplant Congress
Timing and Donor-Specific Antibodies, but Not C4d Deposition, Determine Leukocyte Infiltration in Renal Allograft Biopsies with the Histological Picture of Antibody-Mediated Rejection
J. Callemeyn¹, A. Senev¹, E. Lerut², M. Coemans¹, D. Kuypers¹, W. Gwinner³, M. Essig⁴, D. Anglicheau⁵, P. Marquet⁶, M. Naesens¹
¹Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, ²Department of Pathology, University Hospitals Leuven, Leuven, Belgium, ³Department of Nephrology, Hannover Medical School, Hannover, Germany, ⁴Department of Nephrology, Dialysis and Transplantation, University of Limoges, Limoges, France, ⁵Necker-Enfants Malades Institute, French National Institute of Health and Medical Research U1151, Paris, France, ⁶U850 INSERM, University of Limoges, Limoges, France
*Purpose: Diagnosis of antibody-mediated rejection following kidney transplantation can be challenging, given the limited specificity of individual histological parameters and time-dependent occurrence of histological confounders.…
2019 American Transplant Congress
IL-1β and IL-6 Facilitate T Cell Reconstitution in Heart Allograft Recipients Treated with Anti-Thymocyte Globulin
S. Hasgur, R. Fan, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Antibody-mediated lymphocyte depletion is used in solid organ and stem cell transplantation. However, T cell reconstitution after lymphoablation may lead to acute rejection and…
2019 American Transplant Congress
In Vitro Model for Detection of HLA Antibodies from Long Lived Plasma Cells
M. Merzkani¹, N. Moore¹, X. Benavides¹, B. Smith¹, W. Park¹, A. Bentall¹, K. Medina², M. Gandhi³, M. Stegall¹
¹Transplant, Mayo Clinic, Rochester, MN, ²Immunology, Mayo Clinic, Rochester, MN, ³Transfusion Medicine, Mayo Clinic, Rochester, MN
*Purpose: One of the major causes of kidney allograft loss is antibody mediated rejection. This process is mainly mediated by HLA antibodies(Abs) which are believed…
2019 American Transplant Congress
Long-Term Outcomes after Face Transplantation
B. Kollar, S. Tasigiorgos, M. Turk, E. Bueno, B. Perry, M. Alhefzi, H. Kiwanuka, M. Nizzi, N. Krezdorn, T. Win, M. I. Dorante, V. Haug, D. J. Annino, F. M. Marty, A. Chandraker, S. G. Tullius, L. V. Riella, B. Pomahac
Brigham and Women's Hospital, Boston, MA
*Purpose: Face transplantation (FT) holds promise of restoring form and function to patients with severe facial disfigurement not amenable to traditional reconstructive procedures. However, quantitative…
2019 American Transplant Congress
Optimizing a Protocol for Extended Ex-Vivo Extremity Perfusion
C. J. Stewart¹, M. T. Buchko², X. Wang¹, G. Brandacher³, A. Ladak⁴, D. H. Freed², J. Nagendran²
¹Surgery, University of Alberta, Edmonton, AB, Canada, ²Cardiac Surgery, University of Alberta, Edmonton, AB, Canada, ³Plastic and Reconstruction Surgery, Johns Hopkins University, Baltimore, MD, ⁴Plastic Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Our objective is to demonstrate that Ex-Vivo Extremity Perfusion (EVEP) of a Vascularized Composite Allograft (VCA) is as effective, or superior, to standard cold…
2019 American Transplant Congress
Aquaporins May Be Involved in Renal Ischemia-Reperfusion Injury by Affecting the Pyroptosis of Renal Tubular Epithelial Cells
T. Lin, Y. Fan, Y. Jiang, J. Liu, Z. Wang, L. Li, T. Song, Z. Huang, X. Wang
Organ Transplantation Center, Urology Department, Urology Research Institute, WestChina Hospital, Sichuan University, Chengdu, China
*Purpose: To determine whether aquaporins (AQPs) are involved in renal ischemia-reperfusion injury (IRI) by affecting the pyroptosis of renal tubular epithelial cells.*Methods: Hypoxia reoxygenation (H/R)…
2019 American Transplant Congress
Recombinant Apoptosis Inhibitor of Macrophage Protein Ameliorates Transplant Ischemia-Reperfusion Injury
J. Y. Lee¹, X. Zhang², D. Lian³, A. R. Haig⁴, T. Miyazaki⁵, L. Gunaratnam⁶
¹Department of Microbiology and Immunology, Western University, London, ON, Canada, ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada, ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, Lodnon, ON, Canada, ⁴Department of Pathology, Western University, London, ON, Canada, ⁵Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo, Japan, ⁶Department of Medicine, Western University, London, ON, Canada
*Purpose: Ischemia-reperfusion injury (IRI) during kidney transplantation is associated with acute rejection and long-term graft loss. During IRI, pro-inflammatory mediators (e.g. HMGB1) released from necrotic…
2019 American Transplant Congress
Urinary Exosomal microRNA as a Non-Invasive Biomarker for the Diagnosis of Acute Rejection in Kidney Transplant Recipients
J. Seo¹, Y. Lee¹, S. Jung¹, Y. Kim¹, J. Moon¹, K. Jeong¹, C. Kim², J. Park³, B. Chung⁴, Y. Kim⁵, S. Lee¹
¹Nephrology, Kyung Hee University College of Medicine, Seoul, Korea, Republic of, ²Nephrology, Kyungpook National University College of Medicine, Daegu, Korea, Republic of, ³Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, ⁴Nephrology, The St. Mary’s Hospital of Catholic University of Korea, Seoul, Korea, Republic of, ⁵Nephrology, Inje University College of Medicine, Busan, Korea, Republic of
*Purpose: Acute rejection (AR) is the main obstacle to the graft survival after kidney transplantation. Urinary exosome is a promising source of biomarker for various…
2019 American Transplant Congress
Rapid Detection of Kidney Transplant Injury by Quantifying Donor-Derived Cell-Free Deoxyribonucleic Acid via Massively Multiplex Polymerase Chain Reaction
T. K. Sigdel¹, F. Acosta², S. Navarro², B. Zimmermann², Z. P. Demko², S. Moshkevich², P. R. Billings², M. M. Sarwal¹
¹University of California San Francisco, San Francisco, CA, ²Natera Inc., San Carlos, CA
*Purpose: Plasma donor-derived cell-free DNA (dd-cfDNA) is a proven marker for allograft rejection in patients with kidney transplant (KT). Our goal was to assess performance…