Am J Transplant, Volume 19, Suppl 3 Archives - Page 67 of 214 - ATC Abstracts

2019 American Transplant Congress
Perioperative Blood Transfusion Significantly Increases Inpatient Morbidity and Mortality in Renal Transplant Recipients: 15-year Experience
K. Mahendraraj¹, G. Medrano del Rosal¹, M. Kruse¹, R. Shah¹, T. Katsichtis¹, T. Brennan², N. Nissen², T. Todo², K. Kosari², A. Klein², I. Kim²
¹Surgery, Lincoln Medical Center, New York, NY, ²Transplant Surgery, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: This study evaluates the immediate effects of perioperative blood transfusion (PBT) on inpatient morbidity and mortality among renal transplant (RT) recipients during their index…
2019 American Transplant Congress
Barriers to Pre-Transplant Immunization: A Qualitative Study of Pediatric Liver-Transplant Stakeholders
A. G. Feldman¹, R. Marsh², A. Kempe³, M. Morris²
¹Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado, Aurora, CO, ²University of Colorado, Aurora, CO, ³Pediatrics, University of Colorado, Aurora, CO
*Purpose: Less than 30% of pediatric liver transplant recipients are up-to-date on age-appropriate immunizations at the time of transplant despite being at high-risk for infections…
2019 American Transplant Congress
Ablation of Interferon Regulatory Factor 4 in T Cells Induces “Memory” of Transplant Tolerance That is Irreversible by Immune Checkpoint Blockade
H. Zhang¹, J. Wu², D. Zou³, W. Chen³
¹The second Xiangya Hospital, Changsha, China, ²Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³Immunobiology & Transplant Science Center, Houston Methodist Research Institute, Houston, TX
*Purpose: Achieving alloantigen-specific transplant tolerance through ablation of interferon regulatory factor 4 in T cells*Methods: 1. Irf4fl/flCD4-Cre recipients were first transplanted with BALB/c hearts and…
2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
Y. Huang, H. Xu, Y. Wen, S. Ildstad
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…
2019 American Transplant Congress
Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy
M. Ma, P. Chhabra, K. Brayman
Surgery, University of Virginia, Charlottesville, VA
*Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…
2019 American Transplant Congress
Mortality and Morbidity in Kidney Transplant Recipients with a Failing Graft
N. N. Lam¹, D. J. Boyne², R. R. Quinn², P. C. Austin³, B. R. Hemmelgarn², P. Campbell¹, G. A. Knoll⁴, L. Tibbles², S. Yilmaz², H. Quan², P. Ravani²
¹University of Alberta, Edmonton, AB, Canada, ²University of Calgary, Calgary, AB, Canada, ³ICES, Toronto, ON, Canada, ⁴University of Ottawa, Ottawa, ON, Canada
*Purpose: Due to their history of renal disease and exposure to immunosuppression, kidney transplant recipients with a failing graft may be at higher risk of…
2019 American Transplant Congress
Did COIIN Cohort A Maintain Graft Survival Performance While Increasing Moderate to High KDPI Transplants?
J. Foutz, R. J. Carrico, K. Sisaithong, H. Tosoc-Haskell, D. Klassen
Research, United Network for Organ Sharing, Richmond, VA
*Purpose: The Collaborative Innovation and Improvement Network (COIIN) was a 3-year OPTN project aimed at increasing the utilization of kidneys with a kidney donor profile…
2019 American Transplant Congress
The Safety of Surveillance and Indication Biopsies in Kidney Transplantation: A Series of 2000 Biopsies
A. S. Naik¹, Y. Huang², D. M. Cibrik³, E. Shaban¹, M. McGuire¹, C. Boyer¹, S. P. Norman¹
¹Internal Medicine/Nephrology, Univ of Michigan Medical Ctr, Ann Arbor, MI, ²Internal Medicine/Nephrology, Univ of California Davis, Sacremento, CA, ³Internal Medicine/Nephrology, Kansas University Medical Center, Kansas City, KS
*Purpose: Kidney biopsy (KB) remains the most important diagnostic tool in kidney transplantation. Despite its value, surveillance KB are not routinely done at majority of…
2019 American Transplant Congress
NK Cells Are Associated with Alloimmune Failure in Transplanted Children
E. T. Chambers¹, O. Martinez², M. Robien³, C. Chan¹, R. Ettenger⁴, P. Grimm⁵, H. Lee¹, E. Reed⁴, L. Stempora⁶, M. Sarwal⁷, B. Warshaw⁸, C. Zhao¹, A. D. Kirk⁶
¹Pediatrics, Duke University, Durham, NC, ²Surgery, Stanford, Palo Alto, CA, ³NIH, Bethesda, MD, ⁴Pediatrics, UCLA, Los Angeles, CA, ⁵Pediatrics, Stanford, Stanford, CA, ⁶Surgery, Duke University, Durham, NC, ⁷Pediatrics, UCSF, San Francisco, CA, ⁸Pediatrics, Emory University, Atlanta, GA
*Purpose: Alloimmune failure, defined as the development of donor specific antibody (DSA) and/ or allograft rejection, remains a significant complication in pediatric kidney transplantation. NK…
2019 American Transplant Congress
Apoptotic Exosome-Like Vesicles Induce Endothelial Cell Plasticity and Accelerate Allograft Vascular Remodeling
F. Migneault¹, M. Dieudé¹, J. Turgeon¹, A. Karakeussian Rimbaud¹, D. Beillevaire¹, M. Hardy², A. Brodeur¹, N. Thibodeau¹, C. Perreault², M. Hébert¹
¹CRCHUM, Montreal, QC, Canada, ²IRIC, Montreal, QC, Canada
*Purpose: Acute vascular rejection of allografts is associated with endothelial apoptosis which in turn contributes to the development of transplant vasculopathy. We previously showed that…