Am J Transplant, Volume 19, Suppl 3 Archives - Page 67 of 214 - ATC Abstracts

2019 American Transplant Congress
Development and Validation of a Capillary Blood Mitra-Based Assay for the Quantitative Determination of Advagraf® Concentrations in Transplant Patients
N. Undre¹, I. Dawson², V. Aluvihare³, N. Kamar⁴, F. Saliba⁵, N. Torpey⁶, S. Anaokar⁷, G. Kazeem¹
¹Astellas Pharma Europe Ltd, Chertsey, United Kingdom, ²Covance Laboratories, Harrogate, United Kingdom, ³Kings College Hospital, London, United Kingdom, ⁴CHU Rangueil, Toulouse, France, ⁵Hôpital Paul-Brousse, Villejuif, France, ⁶Addenbrookes Hospital, Cambridge, United Kingdom, ⁷Astellas Pharma Europe Ltd, Surrey, United Kingdom
*Purpose: Therapeutic drug monitoring of tacrolimus (TAC) requires venepuncture blood samples taken by specialists, requiring patients to attend an outpatient clinic; this can be inconvenient…
2019 American Transplant Congress
Costs of Kidney Recoveries Varies Dramatically across Organ Procurement Organizations
J. P. Roberts¹, J. Bragg-Gresham², P. J. Held³
¹Univ of California-San Francisco, San Francisco, CA, ²University of Michigan, Ann Arbor, MI, ³Stanford, Stanford, CA
*Purpose: Report on the wide variation across OPOs in the cost of kidney recovery from deceased donors.*Methods: Cost reports (CMS 216-94 Form) from 52 Independent…
2019 American Transplant Congress
Analysis and Regulation of Immune Reaction in the Transplantation from MHC Homozygous Donors to Heterozygous Recipients with Minor Antigen Mismatches
T. Murata, H. Wada, R. Otsuka, H. Tsuji, A. Sasaki, M. Baghdadi, K. Seino
Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
*Purpose: Induced pluripotent stem cells (iPSCs) is expected to be the source of therapeutic cells in the regenerative medicine. Autologous derivation of iPSCs is the…
2019 American Transplant Congress
Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates
H. Sasaki¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, I. Rosales², B. Cosimi¹, P. Cippa³, T. Fehr³, T. Kawai¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA, ³Medicine, University of Zurich, Zurich, Switzerland
*Purpose: We recently demonstrated that a specific Bcl-2 inhibitor, Venetoclax, can promote mixed chimerism and renal allograft tolerance in non-human primates (NHPs) with reduced myelosuppressive…
2019 American Transplant Congress
Graft-Infiltrating Regulatory T Cells Are Associated with Long Term Cardiac Xenograft Survival
A. K. Singh¹, G. Braileanu¹, A. Hersfield¹, L. DiChiacchio¹, T. Zhang¹, I. Tatarov¹, D. Parsell¹, B. Lewis¹, F. Sentz¹, D. Ayares², M. Mohiuddin¹
¹Department of Surgery, School of Medicine, University of Maryland Baltimore, Baltimore, MD, ²Revivicor, Inc, Blacksburg, VA
*Purpose: Regulatory T (CD4+CD25HiFoxP3+) cells (Treg) are a very small subset of CD4+ T cells that have been shown to play an important role in…
2019 American Transplant Congress
Discovery and Validation of an Early Post-Transplant Biomarker Model Predictive of Chronic Kidney Disease in Liver Transplant Recipients
J. Levitsky¹, S. Asrani², G. Klintmalm², T. Schiano², A. Moss³, K. Chavin⁴, C. Miller⁵, L. Zhao⁶, K. Guo⁶, N. Bridges⁷, J. Odim⁷, M. Brown⁷, D. Ikle⁸, B. Armstrong⁸, M. Abecassis⁹
¹Gastroenterology and Hepatology, Northwestern University, Chicago, IL, ²Baylor, Dallas, TX, ³Mayo Arizona, Phoenix, AZ, ⁴Case Western, Cleveland, OH, ⁵Cleveland Clinic, Cleveland, OH, ⁶Northwestern University, Chicago, IL, ⁷NIAID, Bethesda, MD, ⁸Rho, Chapel Hill, NC, ⁹Comprehensive Transplant Center, Northwestern University, Chicago, IL
*Purpose: A significant proportion of patients develop chronic kidney disease after liver transplantation (LT). We aimed to develop clinical/protein models to predict future GFR deterioration…
2019 American Transplant Congress
Transplantation of Kidneys from Hepatitis C Infected Donors to Hepatitis C Negative Recipients
M. Z. Molnar, O. Cseprekal, M. Yazawa, M. Talwar, V. Balaraman, V. Mas, D. Maluf, R. Helmick, L. Campos, N. Nezakatgoo, C. Eymard, P. Horton, R. Verma, A. Jenkins, C. R. Handley, H. Snyder, C. Cummings, U. A. Agbim, B. Maliakkal, S. K. Satapathy, S. P. Nair, J. D. Eason
Methodist University Hospital Transplant Institute, Memphis, TN
*Purpose: There are no data on the safety of kidney transplantation from hepatitis C (HCV) NAT positive donors to HCV naïve recipients. We report the…
2019 American Transplant Congress
Enhanced Recovery after Surgery Protocols in Kidney Transplantation: Time to Change Practice?
A. M. Elsabbagh, I. Ghoneim, A. Moiz, D. Mckenney, M. A. Zawaideh
St. Vincent Abdominal Transplant Center, St. Vincent Hospital, Indianapolis, IN
*Purpose: Enhanced recovery after surgery (ERAS) is a multi-modal perioperative care pathway designed to facilitate early recovery after major surgery by maintaining preoperative body composition…
2019 American Transplant Congress
Mass Cytometry-Based Characterization of Adaptive Immunity in Transplant Recipients with Self-Limiting or Chronic EBV Viremia
V. H. Ferreira¹, C. J. Guidos², A. Humar¹, D. Kumar¹
¹UHN, Toronto, ON, Canada, ²SickKids Research Inst, Toronto, ON, Canada
*Purpose: SOT recipients are at high risk for EBV-associated PTLD. EBV viremia is a risk factor for PTLD. In some patients viremia is self-limited while…
2019 American Transplant Congress
Kidney Regeneration with Biomimetic Vascular Scaffolds Based on Vascular Corrosion Casts
S. Min¹, H. Mo¹, A. Han¹, J. Ha¹, J. Yoo²
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC
*Purpose: We have developed a biomimetic renal vascular scaffold based on a vascular corrosion casting technique. In this study, we evaluated the feasibility of using…