Am J Transplant, Volume 19, Suppl 3 Archives - Page 67 of 214 - ATC Abstracts

2019 American Transplant Congress
Donate HCV Trial: Transplanting Thoracic Organs from Hepatitis C Donors to Uninfected Patients
A. E. Woolley¹, S. K. Singh², H. J. Goldberg³, M. M. Givertz⁴, M. R. Mehra⁴, A. Coppolino, III⁵, V. Cheng¹, J. Fanikos⁶, D. P. Harrington⁷, H. R. Mallidi², L. R. Baden¹
¹Infectious Diseases, Brigham and Womens Hospital, Boston, MA, ²Cardiac and Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ³Pulmonary, Brigham and Womens Hospital, Boston, MA, ⁴Cardiology, Brigham and Womens Hospital, Boston, MA, ⁵Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ⁶Pharmacy, Brigham and Womens Hospital, Boston, MA, ⁷Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: Given the need for thoracic organs and the high mortality of patients awaiting heart or lung transplantation, it is imperative to find ways to…
2019 American Transplant Congress
Single Cell RNA-seq Analysis of Antibody-Mediated Rejection Reveals Endothelial – Pericyte NOTCH Signaling
A. F. Malone, A. Chadha, H. Wu, S. Ramakrishnan, E. Donnelly, B. D. Humphreys
Washington University School of Medicine, Saint Louis, MO
*Purpose: To precisely define endothelial cell responses in AMR we performed comprehensive single cell RNA-seq on a human kidney biopsy with AMR.*Methods: Single cell libraries…
2019 American Transplant Congress
Promoting Mitochondrial Fusion Alters the Interaction between Endothelial Cells and T Cells in Models of Transplantation
D. T. Tran, C. Atkinson, S. N. Nadig
Medical University of South Carolina, Charleston, SC
*Purpose: As semi-professional antigen-presenting cells, microvascular endothelial cells (mECs) play a central role in mediating allograft rejection. Cold storage and ischemia reperfusion injury increases mEC…
2019 American Transplant Congress
Non-HLA Antibodies against Structural and Non-Structural Target in C4d Negative Antibody Mediated Rejections after Renal Transplantation
S. Kanangat¹, I. Kurbegovic-Skaljic², D. Cimbaluk², M. Oppermann², S. Jensik³, E. Hollinger³, O. Olaitan⁴, R. DeCresce²
¹Tumor Immunology, NIH/NCI Bethesda MD,USA, Bethesda, MD, ²Pathology, Rush University Medical Center, Chicago, IL, ³Surgery, Rush University Medical Center, Chicago, IL, ⁴Tumor Immunology, Rush University Medical Center, Chicago, IL
*Purpose: According to the latest Banff’s criteria approved in 2003, antibody mediated rejections following renal transplantation are divided into 2 types namely C4d + and…
2019 American Transplant Congress
Uterus Transplantation: Recipient Surgery
L. Johannesson, A. Wall, J. Bayer, G. J. McKenna, G. Testa
Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX
*Purpose: The field of uterus transplantation, since the first birth to a uterus transplanted woman in 2014, continues to grow rapidly. As of today at…
2019 American Transplant Congress
Cryopreserved Human Iliac Arteries Allografts: Different Thawing Rates Affect on Their Structural Changes and Mechanical Properties
R. Novotny¹, J. Chlupac¹, R. Matejka², T. Marada¹, P. Mericka³, L. Sterba³, L. Janousek¹, J. Fronek¹
¹Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Department of Biomedical Engineerin, Faculty of Biomedical Engineering, Czech Technical University, Prague, Czech Republic, ³Tissue Bank, Faculty Hospital Hradec Kralove, Hradec Kralove, Czech Republic
*Purpose: The rate of thawing of cryopreserved human iliac arteries allografts (CHIAA) directly affects the severeness of structural changes that occur during this process. This…
2019 American Transplant Congress
Sigma-1 Receptor Agonists Are Renoprotective in a Rat Model of Kidney Transplantation
A. Hosszu¹, Z. Antal², L. Illesy², L. Lenart¹, D. B. Balogh¹, L. Wagner³, A. Vannay⁴, A. J. Szabo², A. Fekete¹
¹"Lendulet" Diabetes Research Group, MTA-SE, Budapest, Hungary, ²1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ³Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, ⁴Pediatrics and Nephrology Research Group, MTA-SE, Budapest, Hungary
*Purpose: Kidney transplantation is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a limiting…
2019 American Transplant Congress
Loss of FXR Exacerbates Liver Damage by Activating NLRP3 Inflammasome Induced Pyroptosis in Liver Ischemia Reperfusion Injury
Z. Zhu, Y. Zhang, Y. Tang, S. Huang, Q. Zhao, W. Ju, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: The relationships among Farnesoid X receptor (FXR), nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome and pyroptosis are largely unknown in…
2019 American Transplant Congress
Pancreatic Extracellular Matrix Improves Human Islet Culture and Function In Vitro
Y. Shindo, R. Pouillot, B. M. Young, P. Link, R. L. Heise, M. F. Levy, M. A. Kanak
Virginia Commonwealth University, Richmond, VA
*Purpose: Islet transplantation is a thriving therapy for patients with Chronic Pancreatitis and Type-1 Diabetes. Within the pancreas, the islets are surrounded by Extracellular Matrix…
2019 American Transplant Congress
Predicting Post-Transplant Graft Function in Deceased Donor Kidney Transplant Recipients
K. Archer¹, Y. Zhang¹, V. Bontha², J. Eason³, L. Gallon⁴, E. Akalin⁵, D. Maluf², V. Mas²
¹OSU, Columbus, OH, ²UTHSC, Memphis, TN, ³UTHSC Director of Transplant Institute, Memphis, TN, ⁴NWU, Chicago, IL, ⁵Albert Einstein College of Medicine, NYC, NY
*Purpose: Discarding donor organs lengthens time patients spend on the kidney transplant (KT) wait list. To identify characteristics associated with short-term outcome in deceased donor…