ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    A National Survey of Immunosuppression Strategies in Intestinal Transplantation

    M. Segovia1, T. Beduschi2, J. Boike3, D. Farmer4, S. Horslen5, K. Iyer6, S. Jafri7, A. Langnas8, C. Matsumoto9, A. Mavis1, G. Mazariegos10, S. Nagai7, J. O'Leary11, Y. Patel1, D. Sudan1, N. Sulejmani7, B. Summers7, T. Schiano6

    1Duke, Durham, NC, 2Univ Miami, Miami, FL, 3NWU, Chicago, IL, 4UCLA, Los Angeles, CA, 5Seattle Child, Seattle, WA, 6Mt Sinai, NY, NY, 7Henry Ford, Detroit, MI, 8UNMC, Omaha, NE, 9Georgetown, Washington, DC, 10UPMC, Pittsburgh, PA, 11Dallas VAMC, Dallas, TX

    *Purpose: Review the management of immunosuppression (IS) for intestinal transplantation (IT) in the USA*Methods: A survey was created and sent via email to surgical directors…
  • 2019 American Transplant Congress

    Increasing Net Immunosuppression after BK Viremia

    L. Cotiguala, A. Masood, J. Park, A. Naik

    University of Michigan, Ann Arbor, MI

    *Purpose: BK viremia is associated with inferior kidney allograft outcomes. Typical treatment involves reduction in immunosuppression. However reduction in immunosuppression is also likely to lead…
  • 2019 American Transplant Congress

    Recipients with Model for End-Stage Liver Disease Sodium Score Driven by Renal Dysfunction Have Increased Post-Transplant Mortality

    T. Bittermann, D. Goldberg

    Gastroenterology, University of Pennsylvania, Philadelphia, PA

    *Purpose: Since the adoption of the Model for End-stage Liver Disease (MELD) score as a primary means of waitlist prioritization for liver transplantation (LT), an…
  • 2019 American Transplant Congress

    Elevated Visceral Adiposity is Associated with Post-Liver Transplant Mortality and Poorly Correlates with BMI in a Prospective Cohort Study

    R. Sharma, R. Rosenblatt, R. Knotts, J. Pisa, E. Verna

    Division of Liver Diseases and Transplantation, Columbia Univerisity Medical Center, New York, NY

    *Purpose: Obesity is increasingly common in end-stage-liver disease (ESLD). While obesity adversely affects outcomes, whether abnormalities in specific adipose tissue (AT) compartments lead to increased…
  • 2019 American Transplant Congress

    Early CXCR5+PD1+ICOS+ Circulating Follicular T Helpers Are Associated with De Novo Donor-Specific Anti-HLA Antibodies after Renal Transplantation

    R. Danger1, M. Chesneau1, F. Delbos2, S. Lebot1, C. Kerleau1, A. Chenouard1, A. Cesbron2, M. Giral3, S. Brouard3

    1CRTI- INSERM UMR 1064- ITUN- Labex IGO -Université de Nantes -CHU Nantes, Nantes, France, 2Laboratoire Histocompatibilité et Immunogénétique - Etablissement Français du sang, Nantes, France, 3Centre d’Investigation Clinique en Biothérapie, Centre de ressources biologiques, Fondation Centaure, CRTI- INSERM UMR 1064- ITUN- Labex IGO -Université de Nantes -CHU Nantes, Nantes, France

    *Purpose: Donor specific anti-HLA antibodies (DSA) are a major risk factor associated with renal allograft outcome. As a trigger of B cell antibody production, T…
  • 2019 American Transplant Congress

    Total Parenteral Nutrition in Ex Vivo Lung Perfusion: Addressing Metabolism Improves Both Inflammation and Overall Graft Performance

    M. T. Buchko, S. Hatami, C. J. Stewart, S. Himmat, D. H. Freed, J. Nagendran

    Department of Surgery, Division of Cardiac Surgery, University of Alberta, Edmonton, AB, Canada

    *Purpose: Contemporary clinical ex vivo lung perfusion (EVLP) protocols generally limit metabolic supplementation to insulin and glucose. Furthermore, conventional perfusates are void of many ingredients…
  • 2019 American Transplant Congress

    Gender Disparity In Access To Liver Transplant Larger In White Than Black Patients

    K. Guo, J. Peipert, M. Abecassis, L. Zhao, D. Ladner

    Northwestern University, Chicago, IL

    *Purpose: Disparities in receipt of liver transplantation (LT) by gender and race have been documented, limiting access to this life saving treatment for particular patient…
  • 2019 American Transplant Congress

    Long Term Renal Function Following Islet Transplantation in the Clinical Islet Transplantation Consortium

    L. G. Hunsicker1, T. L. Eggerman2, M. R. Rickels3, t. Clinical Islet Transplantation (CIT) Consortium4

    1Internal Medicine, U. Iowa, Iowa City, IA, 2NIDDK/NIH, Bethesda, MD, 3Internal Medicine, U. Pennsylvania, Philadelphia, PA, 4Internal Medicine, University of Iowa, Iowa City, IA

    *Purpose: Islet transplantation (IsletTp) is safe and effective treatment of Type 1 diabetes complicated by severe hypoglycemia (Diabetes Care 2016, 39:1230). But the requirement for…
  • 2019 American Transplant Congress

    A Novel Ex Vivo Normothermic Perfusion Model of Human Antibody Mediated Rejection

    P. Chandak1, B. L. Phillips1, R. Uwechue1, C. J. Callaghan1, O. Shaw2, T. Maggs3, L. Woodford3, D. Veniard3, R. Perera4, K. Parmar3, B. Hunt5, D. Bennett6, N. Kessaris1, A. Dorling7, N. Mamode1

    1Transplantation, Guy's and St Thomas Hospitals NHS Trust and King's College London, London, United Kingdom, 2Transplantation and CTL Laboratory, Guy's and St Thomas Hospitals NHS Trust and King's College London, London, United Kingdom, 3Haematology and Thrombosis, Guy's and St Thomas Hospitals NHS Trust, London, United Kingdom, 4Histopathology, Guy's and St Thomas Hospitals NHS Trust, London, United Kingdom, 5Haematology and Thrombosis, Guy's and St Thomas Hospitals NHS Trust and King's College London, London, United Kingdom, 6Interface Physics, University of Bristol, London, United Kingdom, 7Inflammation, Thrombosis and Repair and Transplantation, Guy's and St Thomas Hospitals NHS Trust and King's College London, London, United Kingdom

    *Purpose: Currently, no human experimental model of antibody-mediated rejection (AMR) exists, making the assessment of therapeutic interventions difficult hence the aim of our work is…
  • 2019 American Transplant Congress

    Natural Anti-a Antibody Production In Mice Is Cd4 T Cell-independent

    I. Adam1, B. Motyka2, L. West3

    1Medical Microbiology & Immunology, University of Alberta, Edmonton, AB, Canada, 2Pediatrics, University of Alberta, Edmonton, AB, Canada, 3Pediatrics, Surgery, Immunology, Lab Medicine & Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada

    *Purpose: ABO-incompatible organ transplants (ABOi-Tx) are at high risk of rapid rejection mediated by preformed ABO antibodies (Ab) except during infancy when they are absent.…
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