2019 American Transplant Congress
The Safety of Surveillance and Indication Biopsies in Kidney Transplantation: A Series of 2000 Biopsies
*Purpose: Kidney biopsy (KB) remains the most important diagnostic tool in kidney transplantation. Despite its value, surveillance KB are not routinely done at majority of…2019 American Transplant Congress
NK Cells Are Associated with Alloimmune Failure in Transplanted Children
*Purpose: Alloimmune failure, defined as the development of donor specific antibody (DSA) and/ or allograft rejection, remains a significant complication in pediatric kidney transplantation. NK…2019 American Transplant Congress
Apoptotic Exosome-Like Vesicles Induce Endothelial Cell Plasticity and Accelerate Allograft Vascular Remodeling
1CRCHUM, Montreal, QC, Canada, 2IRIC, Montreal, QC, Canada
*Purpose: Acute vascular rejection of allografts is associated with endothelial apoptosis which in turn contributes to the development of transplant vasculopathy. We previously showed that…2019 American Transplant Congress
Preliminary Mechanistic Studies of Regulatory Dendritic Cell (DCreg) Cell Infusion in Living Donor Liver Transplant Recipients
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: This is a first-in-human phase I/II safety and preliminary efficacy trial of donor-derived regulatory dendritic cells (DCreg) in living donor liver transplantation (LTx) in…2019 American Transplant Congress
Efficacy and Safety Outcomes with De Novo Use of Everolimus-Based Regimen in Renal Transplant Recipients with Delayed Graft Function from the TRANSFORM Study
1TRANSFORM Study Group, Basel, Switzerland, 2Novartis Pharma AG, Basel, Switzerland
*Purpose: To evaluate the effect of everolimus with reduced CNI (EVR+rCNI) vs mycophenolic acid with standard CNI (MPA+sCNI) on efficacy and safety outcomes in RTxR…2019 American Transplant Congress
Long-Term Outcomes in Patients with Obesity and Renal Disease after Sleeve Gastrectomy
Department of Surgery, University of Cincinnati, Cincinnati, OH
*Purpose: Morbid obesity is a barrier to kidney transplantation in patients with end-stage renal disease (ESRD) and is associated with progression of chronic kidney disease…2019 American Transplant Congress
Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates
*Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…2019 American Transplant Congress
How and Why Dyrk1a is Required for Optimal Foxp3+ Treg Functions
Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: TCR-induced calcineurin phosphatase activation and subsequent Nfat dephosphorylation, leading to Nfat translocation to the nucleus, is a key event in conventional T cell activation.…2019 American Transplant Congress
Autoantibody Production Significantly Decreased with APRIL/BLyS Blockade in Murine Chronic Rejection Kidney Transplant Model
University of Wisconsin, Madison, WI
*Purpose: Chronic antibody mediated rejection (cAMR) remains a significant barrier to achieving long-term graft survival in kidney transplantation. Alloantibody production from B lymphocytes and plasma…2019 American Transplant Congress
Technology Triggered Adherence Intervention – Preliminary Findings
1University of Cincinnati, Cincinnati, OH, 2UC Health, Cincinnati, OH
*Purpose: Medication non-adherence (M-NA) after renal transplant (RT) increases the risk of graft failure. We conducted a prospective, randomized, single center trial to evaluate 3…
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