Am J Transplant, Volume 19, Suppl 3 Archives - Page 27 of 214 - ATC Abstracts

2019 American Transplant Congress
Differential Expression of B Cell Activating Factor in Experimental Models of Acute and Chronic Active Antibody-Mediated Rejection
S. Reese, N. Wilson, L. Ptak, R. Redfield, A. Djamali, S. E. Panzer
University of Wisconsin Madison, Madison, WI
*Purpose: The B cell survival cytokine, BAFF [B cell activating factor], promotes B cell maturation and is a marker of disease activity in a variety…
2019 American Transplant Congress
AMD3100 and Low-Dose FK506 Prevent De Novo Donor Specific Antibody Formation and Rejection in a Sensitized Kidney Transplantation Model
A. R. Ahmadi, L. Qi, R. N. Wesson, A. M. Cameron, Z. Sun
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: De novo donor specific antibody (DSA) formation and antibody mediated rejection (AMR) are the main cause of allograft failure long-term. We have developed a…
2019 American Transplant Congress
The Innsbruck Handtransplant Program: Eighteen Years of Experience
F. Messner, T. Hautz, A. Weissenbacher, S. Schneeberger
Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria
*Purpose: Reconstructive transplantation represents a therapeutic option for severe tissue defects which are not amendable to conventional reconstructive attempts. We herein report long-term follow-up data…
2019 American Transplant Congress
Mitochondrial Permeability Regulates Heart Graft Ischemia – Reperfusion Injury and Rejection
A. Qamar¹, J. Jiang¹, X. Huang², P. McLeod², A. M. Jevnikar², Z. Zhang²
¹Pathology and Laboratory Medicine, University of Western Ontario, London, ON, Canada, ²London Health Sciences Centre, London, ON, Canada
*Purpose: A growing body of evidence indicates that mitochondrial permeability transition pore (mPTP) formation plays a crucial role in necroptosis - a programmed form of…
2019 American Transplant Congress
Flow Cytometric Analysis of Leukocyte Migration during Ex Vivo Lung Perfusion with CXCR4 Inhibition
J. Yerxa¹, Q. Gao¹, R. P. Davis², M. Zhang¹, U. Scheuermann¹, W. Parker¹, M. G. Hartwig², A. Barbas¹
¹General Surgery, Duke University, Durham, NC, ²Thoracic Surgery, Duke University, Durham, NC
*Purpose: Ex vivo lung perfusion (EVLP) has emerged as a preservation technique utilized to evaluate candidate donor lungs in a metabolically active state. This also…
2019 American Transplant Congress
Evaluation of New Baskent University Preservation Solution for Liver, Kidney and Intestine Graft during Cold Ischemia: Preliminary Experimental Animal Study
M. Haberal¹, M. Kirnap¹, R. Erdem², H. Ozdemir³, M. Lux², D. Bacanli⁴
¹Transplantation, Baskent University, Ankara, Turkey, ²Pharmacology, Baskent University, Ankara, Turkey, ³Pathology, Baskent University, Ankara, Turkey, ⁴Experimental Laboratory, Baskent University, Ankara, Turkey
*Purpose: Despite significant advances in organ transplantation, damage caused to organs due to long cold ischemia time and perfusion solutions remains a serious hurdle. The…
2019 American Transplant Congress
Transcriptome Profiling Of Renal Transplant Biopsies With Acute Cellular Rejection From Patients On Calcineurin Inhibitor-based Or Cni-avoidance Immunosuppression
D. Dobi¹, F. Vincenti², Z. G. Laszik¹
¹Department of Pathology, University of California, San Francisco, San Francisco, CA, ²Departments of Medicine and Surgery, University of California, San Francisco, San Francisco, CA
*Purpose: Despite their suboptimal toxicity profile, calcineurin-inhibitors (CNIs) remain the cornerstone of renal transplant immunosuppression. Previous efforts to completely eliminate CNIs failed, because CNI-avoidance protocols…
2019 American Transplant Congress
Assessment of the Relationship between Inflammation and Glomerular Filtration Rate
J. B. Ramirez-Gonzalez¹, L. E. Morales-BuenRostro², J. Furuzawa-Carballeda³, L. Garcia-Covarrubias⁴, R. L. Pacheco-Domínguez⁵, R. Durazo-Arvizu⁶, J. Alberu³, E. N. Cuevas-Medina⁷, M. López-Cervantes⁵, R. A. Osorio-Juárez⁵
¹Faculty of Medicine, Public Health Department, Universidad Nacional Autónoma de México, Mexico, Mexico, ²Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ³Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ⁴Department of Transplantation, Hospital General de México Doctor Eduardo Liceaga, Mexico, Mexico, ⁵Faculty of Medicine, Department of Public Health, Universidad Nacional Autónoma de México, Mexico, Mexico, ⁶Department of Public Health Sciences, Loyola University Chicago, Chicago, IL, ⁷Department of Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico, Mexico
*Purpose: Since the inflammatory phenomena that occur after transplantation are decisive factors for developing renal rejection, we decided to study how the elevation of some…
2019 American Transplant Congress
Dynamic Characterization of Cells in the Perfusate from Cold Ischemic Liver Grafts
R. J. de Vries, C. Pendexter, S. E. Cronin, B. Marques, J. F. Markmann, S. L. Stott, H. Yeh, M. Toner, K. Uygun, S. N. Tessier
Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Injury during preservation is a complex process that affects graft function. A deeper understanding and better prediction of liver viability are demanded to improve…
2019 American Transplant Congress
Monitoring Inflammatory Cytokine Levels in Kidney Transplant Patients (KTx Pts) with Chronic Antibody Mediated Rejection (cABMR) Treated with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody)
S. Ge¹, A. Petrosyan¹, M. Chu¹, N. Ammerman², A. Vo², S. C. Jordan², X. Zhang³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, ³HLA Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: IL-6 is a pro-inflammatory cytokine involved in KTx rejection. A clinical trial to improve cABMR using CLZ in HLA-sensitized KTx Pts is underway. Inhibition…