Am J Transplant, Volume 19, Suppl 3 Archives - Page 27 of 214 - ATC Abstracts

2019 American Transplant Congress
A Multicenter Study Of mTOR Inhibitor Use In Intestine And Multivisceral Transplantation
M. C. Segovia¹, A. Mavis¹, J. Boike², Y. Patel¹, T. Schiano³, S. Jafri⁴
¹Duke, Durham, NC, ²NWU, Chicago, IL, ³Mt Sinai, NY, NY, ⁴Henry Ford, Detroit, MI
*Purpose: Review the frequency, indications and outcomes of the use of mTOR inhibitors (mTOR) after intestine (IT) and multivisceral transplantation (MVT) at multiple centers in…
2019 American Transplant Congress
Comparison of Simultaneous Pancreas kidney Transplantation to Kidney Transplantation Alone for Type 2 Diabetes with End Stage Renal Disease
Y. Fu, Z. Shen
Kidney&Pancreas Transplant, Tianjin First Center Hospital, Tianjin, China
*Purpose: To compare the clinic outcomes of simultaneous pancreas-kidney transplantation (SPK) with kidney transplantation alone (KTA) in Type 2 Diabetes patients with ESRD.*Methods: 97 type…
2019 American Transplant Congress
Human Neutrophil Function against Pathogens in Solid Organ and Stem Cell Transplant Recipients
N. Barros, N. Alexander, Z. Dagher, S. Knooihuizen, A. Viens, A. R. Hopke, D. Irimia, M. K. Mansour
Transplant Infectious Diseases, Massachusetts General Hospital, Boston, MA
*Purpose: The effects of solid organ (SOT) and allogeneic stem cell transplantation (SCT) on the neutrophil function is not well described. In this study, we…
2019 American Transplant Congress
Restrictive Medicaid Policies Reduce Access to Liver Transplant for Alcohol-Associated Liver Disease
B. P. Lee, V. Eric, P. Mark, J. Dodge, N. Terrault
UCSF, SF, CA
*Purpose: Medicaid policies requiring specific documentation of abstinence (e.g. 6 months) and/or rehabilitation for financial coverage of liver transplant (LT) for alcohol-associated liver disease (ALD)…
2019 American Transplant Congress
Costimulatory Blockade and Allo-Specific Treg Therapy for Liver Transplant Recipients: Preclinical Data
L. Contreras-Ruiz¹, K. Shimozawa², R. Zhang¹, L. Turka³, J. F. Markmann³, E. C. Guinan²
¹Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, ²Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, ³Center of Transplantation Sciences, Massachussetts General Hosp., Boston, MA
*Purpose: Adoptive transfer of ex vivo generated donor-specific regulatory T cells (Treg) by using CD28/B7 costimulatory blockade (CSB) to induce transplant (TX) tolerance and minimize…
2019 American Transplant Congress
A Novel Method for Ex Vivo Treg Expansion via Human iNKT Cell Activation
R. Ishii¹, I. Masako¹, H. Katsumata¹, T. Kanzawa¹, T. Yamakawa¹, H. Ishigooka¹, T. Hirai¹, K. Saiga¹, M. Okumi¹, Y. Ishii², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Vaccine Innovation Laboratory RIKEN Cluster for Science, Technology and Innovation Hub (RCSTI), Kanagawa, Japan
*Purpose: Tregs play a critical role in immune tolerance. If Tregs can be administered to patients suffering from immune disorders, most therapies employing existing immunosuppressants…
2019 American Transplant Congress
Chimeric Allografts Induced by Stem Cell Mobilizing Agents in a Mouse Model of Kidney Transplantation: Role of CD133 Stem Cells
J. Zhou, l. Qi, A. Ahmadi, R. Wesson, A. Cameron, J. Burdick, Z. Sun
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: It has been reported that a stem cell mobilizing therapy using a combination of AMD3100 and low dose FK506 (AF) enabled immunosuppressive-free long-term kidney…
2019 American Transplant Congress
α -1,3-galactosyltransferase Knockout Porcine Tissue And Organ May Reduce The Risks Of Antibody Mediated Rejection Via Less Rhesus Igm Cross-reactivity.
J. Yoon, B. Ezekian, M. Manook, J. Kwun, S. Knechtle
Duke Transplant Center, Durham, NC
*Purpose: Previously, we observed that sera from rhesus macaques contained preformed antibodies against wild type (WT) swine splenocytes. In the context of xenotransplantation, preformed xenoantibodies…
2019 American Transplant Congress
Blockade of C3aR1 Signaling Suppresses Alloreactive CD8⁺ T Cell Immunity and Prolongs Murine Cardiac Allograft Survival
J. Horwitz, D. Mathern, P. Heeger
Icahn School of Medicine at Mount Sinai, NY, NY
*Purpose: Activation, differentiation and expansion of alloreactive CD8+ T cells, the dominant effectors that mediate murine heart allograft rejection, requires allorecognition, costimulation, and cytokine-initiated signals.…
2019 American Transplant Congress
National Landscape of Hope Act Transplant Candidates and Recipients in the United States
A. R. Wilk¹, R. Hunter², M. A. McBride², D. K. Klassen²
¹Research, United Network for Organ Sharing, Richmond, VA, ²United Network for Organ Sharing, Richmond, VA
*Purpose: The HIV Organ Policy Equity (HOPE) Act, enacted on 11/21/13, allows for the transplantation of organs from HIV+ donors into HIV+ recipients in the…