Am J Transplant, Volume 19, Suppl 3 Archives - Page 182 of 214 - ATC Abstracts

2019 American Transplant Congress
Incidence of De Novo Donor Specific Antibodies and Treatment Response for AMR in Pediatric Kidney Transplant Recipients
S. Gattis¹, R. Liverman¹, A. Serluco¹, J. Yin¹, H. C. Sullivan², R. A. Bray³, H. M. Gebel³, S. Jernigan⁴, R. George⁴, P. D. Winterberg⁴, R. Garro⁴
¹Children's Healthcare of Atlanta, Atlanta, GA, ²Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, ³Emory University Hospital, Atlanta, GA, ⁴Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
*Purpose: Antibody-mediated rejection (AMR) is a significant complication in renal transplant patients. The aim of this study was to evaluate the incidence of de novo…
2019 American Transplant Congress
Long Term Impact of Intraoperative Autologous Blood Transfusion on HCC Recurrence in Liver Transplantation
G. Kelly¹, J. L. Pasko¹, E. Dewey², E. Maynard¹, S. L. Orloff¹, C. Enestvedt¹
¹Division of Abdominal Transplant, OHSU, Portland, OR, ²Department of General Surgery, OHSU, Portland, OR
*Purpose: The aim of this study was to determine whether intraoperative autologous transfusion in liver transplant patients with HCC affects the rate of recurrence.*Methods: We…
2019 American Transplant Congress
Discovery and Validation of Blood Genomic Signatures of Acute Rejection in Liver Transplant Recipients
J. Levitsky¹, N. Bridges², J. Odim², M. Brown², D. Ikle³, B. Armstrong³, A. Demetris⁴, S. Asrani⁵, G. Klintmalm⁵, T. Schiano⁶, A. Moss⁷, K. Chavin⁸, C. Miller⁹, M. Kandpal¹⁰, L. Zhao¹⁰, S. Kurian¹¹, M. Abecassis¹⁰
¹Div of Gastroenterology & Comprehensive Tx Cnt, Chicago, IL, ²NIAID, Bethesda, MD, ³Rho, Chapel Hill, NC, ⁴UPMC, Pittsburgh, PA, ⁵Baylor, Dallas, TX, ⁶Mount Sinai, New York, NY, ⁷Mayo Arizona, Phoenix, AZ, ⁸Case Western, Cleveland, OH, ⁹Cleveland Clinic, Cleveland, OH, ¹⁰Comprehensive Transplant Center, Chicago, IL, ¹¹Scripps, San Diego, CA
*Purpose: Biomarker profiles diagnostic of acute rejection (AR) could enhance the management of liver transplant (LT) recipients. Our aim was to discover and validate blood…
2019 American Transplant Congress
A Regulatory T Cell-Intrinsic Role for Ikaros in Acquired Transplant Tolerance
R. M. Thomas, L. Wang, W. W. Hancock, A. D. Wells
The Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Ikaros is a transcriptional repressor encoded by the Ikzf1 gene that was recently identified as the pharmacologic target of thalidomide analogs in successful therapy…
2019 American Transplant Congress
Early T Cell Infiltration is Modulated by PD-1/PD-L1 Interactions in Kidney Graft
Y. Shim, R. Fan, N. Dvorina, W. Baldwin
Inflammation and Immunity, Lerner Research Institute, Cleveland, OH
*Purpose: Allogeneic transplants elicit dynamic T cell responses that are modulated by positive and negative co-stimulatory receptors. We have investigated the impact of PD-1, a…
2019 American Transplant Congress
Excellent Outcomes in Liver Transplantation under Charity Care: An Opportunity to Mitigate Socio-Economic Disparities in Access to Transplantation
F. Paterno¹, J. Rosado¹, R. Olivo², S. Gavzy¹, L. Brown¹, D. Wilson¹, B. Koneru¹, N. Pyrsopoulos², J. V. Guarrera¹
¹Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, Newark, NJ, ²Department of Medicine, Division of Hepatology, Rutgers New Jersey Medical School, Newark, NJ
*Purpose: Lack of health insurance is a major barrier in the access to health care even in the case of life-threatening conditions like end-stage liver…
2019 American Transplant Congress
The Centennial Allograft? Observation Of Greater Than 100-year Allograft Survival Is More Common Among Liver Allograft Recipients Than Renal Allograft Recipients.
J. F. Renz, A. C. Gruessner, R. C. Misawa, A. Masi, R. W. Gruessner
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: We investigated the occurrence of deceased-donor liver (DDOLT), deceased-donor renal (DDRT), and living-donor renal allografts (LDRT) that have achieved 100 years or more of…
2019 American Transplant Congress
CURATE.AI: Personalized Liver Transplant Tacrolimus Dosing
A. Zarrinpar¹, T. Kee², P. Wang³, J. Khong³, U. Kim¹, J. Chong², J. B. Jeong³, A. T. Truong², S. Tan², B. K. Betzler², W. Ng², C. Ho³, D. Ho²
¹Surgery, University of Florida, Gainesville, FL, ²National University of Singapore, Singapore, Singapore, ³UCLA, Los Angeles, CA
*Purpose: Transplant immunosuppressive regimens include multiple drugs with varying pharmacokinetics, metabolic pathways, and drug-drug interactions. This study aimed to use CURATE.AI, an artificial intelligence platform,…
2019 American Transplant Congress
Lower Alcohol Taxes Are Associated with Increased Liver Transplant Listing
N. T. Shen¹, M. Raver¹, N. Hutchison¹, A. Jesudian¹, J. Bray², B. Schackman³, R. S. Brown¹
¹Medicine; Division of Gastroenterology and Hepatology, New York Presbyterian Hospital - Weill Cornell, New York, NY, ²Economics, University of North Carolina at Greensboro, Greensboro, NC, Greensboro, NC, ³Healthcare Policy and Research, Weill Cornell Medicine, New York, NY
*Purpose: Alcoholic liver disease (ALD) is a leading indication for liver transplantation worldwide with rising prevalence. Whether relationships exist between transplant listing for ALD and…
2019 American Transplant Congress
Redox State of HMGB1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation
R. A. Sosa¹, A. Q. Terry¹, J. Nevarez-Mejia¹, M. Rossetti¹, B. V. Naini¹, V. M. Groysberg¹, F. M. Kaldas², R. W. Busuttil², D. W. Gjertson¹, J. W. Kupiec-Weglinski², E. F. Reed¹
¹Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, ²Surgery, UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor of acute and chronic graft rejection in orthotopic liver transplantation (OLT) involving a complex interplay between…