ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Comparison Of Estimating Glomerular Filtration Equations In Living Kidney Donor Candidates Prior To Donation

S. Hebert1, J. Xu2, H. Ibrahim1

1Nephrology, Hypertension and Transplantation, Houston Methodist Hospital, Houston, TX, 2Houston Methodist Research Institute, Houston, TX

Meeting: 2019 American Transplant Congress

Abstract number: B292

Keywords: Donation, Glomerular filtration rate (GFR), Kidney, Screening

Session Information

Date: Sunday, June 2, 2019

Session Name: Poster Session B: Kidney Living Donor: Selection

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

Related Abstracts
  • Creatinine (Creat) and Cystatin C (CysC) Based Glomerular Filtration Rate (GFR) Estimating Equations Are More Precise Than Creatinine-Only-Based Equations in Former Living Kidney Donors
  • Comparison of the Estimated and Measured Glomerular Filtration Rate in Kidney Donor Candidates.

*Purpose: Serum creatinine-based estimated glomerular filtration rate (eGFR) models have been shown to over- or underestimate measured iohexol GFR (mGFR), but it is unclear if combining these estimating equations could more accurately predict mGFR in living kidney donor candidates.

*Methods: Using 533 living kidney donors from August 2008 – November 2010, we compared the Modification of Diet in Renal Disease (MDRD), Cockcroft-Gault (CG), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR models with mGFR by iohexol clearance. As the MDRD model was derived from a population with low mean GFR (40 mL/min), we incorporated a previously published refitted model (MDRD*), developed from a cohort with more similar mean GFR (123 mL/min) as our healthy kidney donors. We assessed the performance of these estimating models against mGFR in: bias, precision, and relative accuracy.

*Results: The mean measured GFR in our population was 110.3 ± 16.51 ml/min/1.73 m2 with a mean serum creatinine at donation of 0.83 ± 0.16 mg/dL. Analysis of the individual estimating models showed that eGFR(CG) underestimated mGFR by 4.93 ± 22.33 mL/min/1.73 m2 and eGFR(MDRD*) overestimated mGFR by 6.92 ± 15.87 mL/min/1.73 m2. Averaging eGFR (MDRD*) and eGFR (CG) provided the least bias model with the best accuracy. It overestimated mGFR by 1 ± 18.51 mL/min/1.73 m2 and was within 10% of mGFR 49.9% of the time. Moreover, this combined equation was within 30% of mGFR 91% of the time.

*Conclusions: Averaging the refitted MDRD* and CG equations provided the least biased and most accurate model for estimating GFR in kidney donors prior to transplantation.

 border=

 border=

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Hebert S, Xu J, Ibrahim H. Comparison Of Estimating Glomerular Filtration Equations In Living Kidney Donor Candidates Prior To Donation [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/comparison-of-estimating-glomerular-filtration-equations-in-living-kidney-donor-candidates-prior-to-donation/. Accessed February 25, 2021.

« Back to 2019 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Home
  • Search
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.