2019 American Transplant Congress
Decay Accelerating Factor (DAF) Regulates Germinal Center B-cell and Alloantibody Formation
*Purpose: High affinity IgG antibodies including alloantibodies result from germinal center (GC) reactions in which somatic hypermutation and positive selection cause affinity maturation. When we…2019 American Transplant Congress
Belatacept Treated Patients Experience Improved Health-Related Quality of Life and Lower Symptom Distress Compared to Cyclosporine Treated Patients: An Analysis of the Benefit and Benefit-EXT Cohorts
1Terasaki Research Institute, Los Angeles, CA, 2Bristol Myers Squibb, Princeton, NJ
*Purpose: New immunosuppressive agents in transplant should not only be efficacious but also help patients feel better (i.e. lower patient reported symptoms and improve health…2019 American Transplant Congress
Belatacept Based CNI Free Immunosuppression in Pancreas Transplantation. Results at 4 Years
Indiana University School of Medicine, Indianapolis, IN
*Purpose: CNI based Immunosuppression is a well known risk factor for worsening renal function. We report our experience in converting Pancreas Transplant recipients from tacrolimus…2019 American Transplant Congress
Racial/Ethnic and Socio-Economic Disparities: Single versus Multi-Organ Transplant Recipients
*Purpose: Under current deceased donor kidney allocation policy, multi-organ transplant (MOT) candidates often receive priority over single organ transplant (SOT) candidates. We examined the distribution…2019 American Transplant Congress
Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection in Solid Organ Transplant Recipients at an Academic Medical Center
Center for Transplantation, University of California, San Diego Health System, La Jolla, CA
*Purpose: In the United States, the incidence of Clostridium difficile infection (CDI) has increased remarkably and remains a significant burden in the solid organ transplant…2019 American Transplant Congress
Myeloid AXL Promotes Cardiac Allograft Vasculopathy
*Purpose: Cardiac Allograft Vasculopathy (CAV) is a significant contributor to long term transplant rejection, despite advances in immunotherapy. Reactivity to alloantigen presentation may occur by…2019 American Transplant Congress
Dual Targeting Desensitization with Carfilzomib Plus Lulizumab Significantly Prolongs Kidney Transplant Survival in Allosensitized Nonhuman Primates
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Sensitized patients are difficult to transplant due to pre-formed immunity against MHC antigens; thus, new strategies for desensitization are needed to improve outcomes in…2019 American Transplant Congress
Recipient Antibiotics Pretreatment Protects Liver Transplants from Ischemia-Reperfusion Injury via Prostaglandin E2: From Bench-to Bedside
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: We and others have reported on benefits of endoplasmic reticulum (ER) stress modulation and autophagy enhancement to mitigate ischemia-reperfusion injury (IRI) in orthotopic liver…2019 American Transplant Congress
What Are You Smoking? The Impact of Donor Drug Use on Long Term Survival Post-Transplant
*Purpose: Drug use is a common aspect in the history of heart transplant donors. Whether prior or current drug use is associated with inferior post…2019 American Transplant Congress
Four-Year Follow Up of Kidney Transplantation Using Alemtuzumab Induction and Belatacept/Sirolimus Maintenance Therapy
1Surgery, Duke University, Durham, NC, 2Transplant Center, Emory University, Atlanta, GA
*Purpose: Kidney transplantation remains limited by the chronic toxicities associated with calcineurin inhibitors (CNIs) and steroids. The objective of this clinical trial was to determine…
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