Session Name: Poster Session C: Kidney: Cardiovascular and Metabolic
Date: Monday, June 3, 2019
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: Compared to the general population, kidney transplant recipients are at increased risk of hemorrhage and thrombosis. Whether this risk is affected by kidney function and albuminuria is unknown.
*Methods: We conducted a retrospective cohort study using linked healthcare databases to identify adult kidney transplant recipients from 2002-2015 in Alberta, Canada. Estimated glomerular filtration rate (eGFR) and albuminuria measurements at 1-year posttransplant were used to categorize recipients (eGFR: ≥45 vs. <45 mL/min/1.73 m2; albuminuria: normal vs. mild-heavy). We determined the association between categories of eGFR and albuminuria and posttransplant hemorrhage and venous thrombosis based on diagnostic and procedural codes.
*Results: Of 1,284 kidney transplant recipients, 21% had an eGFR <45 mL/min/1.73 m2 and 40% had mild-heavy albuminuria. Over median follow-up of 6 years, the age- and sex-adjusted rate of hemorrhage and thrombosis was over 2-fold higher in recipients with lower eGFR and mild-heavy albuminuria compared to higher eGFR and normal albuminuria (hemorrhage: incidence rate ratio, IRR, 2.6, 95% CI 1.5-4.4; thrombosis: IRR 2.3, 95% CI 1.1-5.0).
*Conclusions: Among kidney transplant recipients, the risk of hemorrhage and venous thrombosis is increased when eGFR is reduced or albuminuria is present.
To cite this abstract in AMA style:Lam NN, Ravani P, Quinn RR, Tonelli M, Ye F, Hemmelgarn BR, Sood MM. Renal Function, Albuminuria, and the Risk of Hemorrhage and Thrombosis after Kidney Transplantation [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/renal-function-albuminuria-and-the-risk-of-hemorrhage-and-thrombosis-after-kidney-transplantation/. Accessed May 9, 2021.
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