2019 American Transplant Congress
A Kidney Transplant Recipient with Severe Acute GvHD Promptly Rescued by Donor HLA-Targeted Serotherapy
*Purpose: Acute Graft-versus-Host Disease (GvHD) is a rare but frequently lethal complication after solid organ transplantation (SOT). In intestinal transplant recipients, anti-HLA Donor-Specific Antibody (DSA)…2019 American Transplant Congress
Impact of Liver Recipient Genotype on Tacrolimus
*Purpose: In kidney transplant recipients, recipient genotype (CYP3A5 *3) has the greatest influence on tacrolimus pharmacokinetics (PK). However, in liver transplant recipient, donor liver and…2019 American Transplant Congress
Galectin-3 and Long-Term Graft Failure in Renal Transplant Recipients: A Prospective Cohort Study
*Purpose: Galectin-3 has been associated with renal fibrosis and decline of renal function. We aimed to determine the association of galectin-3 with long-term risk of…2019 American Transplant Congress
IL-6R Blockade with Tocilizumab Increases Tregs and Decreases Early Graft Inflammation in Kidney Transplant Recipients: Results of a Randomized Controlled Trial
*Purpose: IL-6, a proinflammatory cytokine and key regulator of Treg/Th17 balance, is strongly associated with renal graft rejection. We hypothesized that IL-6 blockade with tocilizumab…2019 American Transplant Congress
The Risk of Systematic Error in Kidney Transplant Opioid Research
Medical University of South Carolina, Charleston, SC
*Purpose: Opioid use before and after kidney transplant is strongly associated with morbidity and mortality; yet data assessing opioid utilization has centered on sources with…2019 American Transplant Congress
Adult Living Donor vs. Deceased Donor Liver Transplant (LDLT vs. DDLT) at a Single US Center- Time to Change Our Paradigm for Liver Transplant
Thomas E Starzl Transplant Inst, Pittsburgh, PA
*Purpose: LDLT remains underutilized in the US. We compared outcomes between LDLT and DDLT at our center to highlight the advantages of LDLT.*Methods: Retrospective review…2019 American Transplant Congress
Improving Access to Lung Transplant through Donor Strategy: A Decision Analysis
Cleveland Clinic, Cleveland, OH
*Purpose: The use of Donation after Cardiac Death (DCD) donors in addition to Donation after Brain Death (DBD) donors may increase patient access to lung…2019 American Transplant Congress
Platelets Augment Granzyme K Production By Macrophages In Antibody-mediated Rejection
Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH
*Purpose: When antibodies bind to MHC antigens on endothelial cells a cascade of responses is initiated including exocytosis of adhesion molecules followed by attachment and…2019 American Transplant Congress
Variation in Racial Disparities in Liver Transplant Outcomes by Hospital Quality
Emory University, Emory Transplant Center, Atlanta, GA
*Purpose: Black patients experience inferior outcomes after liver transplant (LTx). Studies of other outcomes have shown that disparities are partially attributable to variation in quality…2019 American Transplant Congress
Increasing Time-in-Therapeutic Range of Tacrolimus is Associated with Superior Outcomes in Living Kidney Transplants
*Purpose: Tacrolimus-based regimens remain the backbone of maintenance immunosuppressive therapy in kidney transplant, and therapeutic drug monitoring of tacrolimus is necessary due to a narrow…
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