Am J Transplant, Volume 19, Suppl 3 Archives - Page 122 of 214 - ATC Abstracts

2019 American Transplant Congress
Damage-Associated Molecular Pattern Release and Toll-Like Receptor Activation during Cold Storage and Ex Vivo Reperfusion of Old Rat Livers
U. Scheuermann, E. R. Seyferth, M. Zhu, M. Song, J. Yerxa, R. P. Davis, W. Parker, M. Hartwig, J. Kwun, J. Lee, A. S. Barbas
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Donor age is one of the most important predictive factors of graft outcome in liver transplantation. The aim of this study was to investigate…
2019 American Transplant Congress
The Impact of Thrombin / Protease-Activated Receptor-1 Pathway in Hepatic Ischemia-Reperfusion Injury in Mice
D. Noguchi, N. Kuriyama, T. Fujii, H. Kato, M. Kishiwada, S. Mizuno, M. Usui, H. Sakurai, S. Isaji
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
*Purpose: Coagulation cascade is an important pathway in the pathophysiology of hepatic ischemia-reperfusion injury(IRI). Generation of thrombin is a critical factor of coagulation induced by…
2019 American Transplant Congress
Increased Ratio of Circulating Tfh for Tfr Cells in Chronic Renal Allograft Dysfunction: A Pilot Study
L. Yan, Y. Li, Y. Li, X. Wu, X. Wang, L. Wang, Y. Shi, J. Tang
West China Hospital OF Sichuan University, Chengdu, China
*Purpose: T follicular helper (Tfh) cells play a central role in contribution of B cell differentiation and antibody production. T follicular regulatory (Tfr) cells inhibit…
2019 American Transplant Congress
Contribution of CD38 to Methionine Choline Deficient (MCD) Diet-Induced Liver Injury in Rats
J. Kim, Y. Lee, B. F. Reader, C. Akateh, K. R. Maynard, K. W. Washburn, J. L. Zweier, B. A. Whitson, S. M. Black
Department of Cardiac Surgery, The Ohio State Univ. Medical Center, Columbus, OH
*Purpose: Nonalcoholic fatty liver disease (NAFLD) and associated non-alcoholic steatohepatitis (NASH) is a rising cause of end stage liver disease, increasing the need for liver…
2019 American Transplant Congress
Normothermic Ex-Situ Liver Perfusion Parameters of Liver Viability in a Porcine Model of Liver Transplantation with Marginal Grafts
I. Linares-Cervantes¹, J. Echeverri¹, S. Cleland¹, M. Kaths¹, R. Rosales¹, T. Goto¹, D. Kollmann¹, M. Hamar¹, P. Urbanellis¹, L. Mazilescu¹, S. Ganesh¹, O. Adeyi¹, P. Yip¹, B. Bojko², P. Gorynzka², K. Gorynski², D. Grant¹, N. Selzner¹, M. Wasowicz¹, M. Selzner¹
¹Toronto General Hospital, Toronto, ON, Canada, ²University of Nicolaus Copernicus, Torun, Poland
*Purpose: Evaluate parameters of liver viability during normothermic ex-situ liver perfusion (NEsLP) prior to transplantation.*Methods: In this study, we investigated prior assessed parameters and new…
2019 American Transplant Congress
Prevalence of Donor Specific Antibody in Heart Transplant Recipients with Antibody-Mediated Rejection as Compared to Abnormal Intragraft mRNA Transcripts by Molecular Microscope System
K. Shah, R. J. Levine, S. Dimbil, S. Sana, P. F. Halloran, J. Patel, D. H. Chang, E. Kransdorf, M. Kittleson, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Antibody-mediated rejection (AMR) is defined by pathologic evaluation of endomyocardial biopsy (EMB) for both histologic and immunopathologic components. Detectable donor specific antibodies (DSAs) in…
2019 American Transplant Congress
Is Muscular Dystrophy A Contraindication To Heart Transplantation?
M. Kittleson, J. Patel, D. H. Chang, S. Dimbil, R. Levine, L. Czer, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Patients with muscular dystrophy may have an associated cardiomyopathy, resulting in advanced heart failure requiring transplantation. However, the skeletal muscle dysfunction can result in…
2019 American Transplant Congress
HOPE Act Deceased Donors Referrals: Barriers to Donation
O. Kusemiju, C. Durand, B. Doby, M. Bowring, B. Barnaba, W. Werbel, D. Brown, A. Tobian, S. Seaman, D. Ostrander, D. Segev
Johns Hopkins University, Baltimore, MD
*Purpose: HIV+ deceased donors (D+) represent a unique resource for HIV+ recipients but HIV D+ may have medical contraindications to donation or lower authorization rates.…
2019 American Transplant Congress
Transplant Outcomes of DCD Kidneys Recovered with vs. without Pre-Recovery Heparin Administration
J. Narvaez, L. Kayler
Division of Transplantation, University at Buffalo, Buffalo, NY
*Purpose: DCD kidney transplants are associated with higher rates of delayed graft function (DGF) and primary non-function (PNF) likely due to ischemic events during recovery.…
2019 American Transplant Congress
Impact of Cold Ischemia Time on DCD Kidney Transplant Outcomes
J. Narvaez, L. Kayler
Transplant Surgery Division, Dept of Surgery, University at Buffalo, Buffalo, NY
*Purpose: Kidney transplantation (KTX) from Donation after Circulatory Death (DCD) donors is associated with high rates of delayed graft function (DGF) and potential worse graft…