Date: Monday, June 3, 2019
Session Name: Poster Session C: Kidney: Cardiovascular and Metabolic
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: Studies have previously shown that total parathyroidectomy in the renal transplant patient may adversely affect allograft function. The primary aim of this study was to assess the effect of partial parathyroidectomy on allograft function in the renal transplant population. The secondary aim was to assess corrected calcium, phosphate and parathyroid hormone levels following surgery.
*Methods: This was a retrospective study of 10 renal transplant patients who underwent partial parathyroidectomy between January 2012 and January 2016. Pre-operative estimated glomerular filtration rate (eGFR), corrected calcium, phosphate and parathyroid hormone (PTH) levels were collected. This was compared with results at one and twelve months after surgery. The paired t-test was performed for statistical analysis.
*Results: The mean patient age was 64 years old, and all patients had hyperparathyroidism requiring parathyroidectomy due to persistent hypercalcaemia. Subtotal parathyroidectomy was performed in 5 (50%) patients, biglandular in 3 (30%) and uniglandular in 2 (20%). Compared with pre-parathyroidectomy values, there was no difference in eGFR one month after surgery (45.2 mL/min/1.73m2 vs 44.9 mL/min/1.73m2, P = 0.9), or at twelve months after surgery (45.2 mL/min/1.73m2 vs 51.8 mL/min/1.73m2, P = 0.074). There was a significant decrease in corrected calcium (2.71mmol/L vs 2.37mmol/L, P= 0.013) twelve months after surgery, with no significant change in the PTH (346 pg/mL vs 189 pg/mL, P = 0.11) or phosphate level (0.92 mmol/L vs 0.93 mmol/L, P= 0.68).
*Conclusions: There was no significant difference in allograft function twelve months following partial parathyroidectomy in renal transplant patients. Partial parathyroidectomy appears to be a safe intervention in the renal transplant population, with clear improvement in the serum corrected calcium level.
To cite this abstract in AMA style:Gao M, Vilayur E, Ferreira D, Bendinelli C, Sankoorikal C. Partial Parathyroidectomy And Allograft Function In Renal Transplant Patients [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/partial-parathyroidectomy-and-allograft-function-in-renal-transplant-patients/. Accessed March 1, 2021.
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