Am J Transplant, Volume 19, Suppl 3 Archives - Page 112 of 214 - ATC Abstracts

2019 American Transplant Congress
Beta₂-Adrenergic Receptor Activation Prolongs Survival of Vascularized Composite Tissue Allotransplants in a Murine Model
M. Kim¹, D. Fisher¹, J. Loo¹, P. Bogner², U. Sharma³, J. Skitzki¹, E. Repasky⁴
¹Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ²Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ³Cardiology, University at Buffalo, Buffalo, NY, ⁴Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY
*Purpose: Transplantation of faces, hands, and limbs using vascularized composite allotransplantation (VCA) has faced significant challenges hindering its routine implementation in the clinic. One critical…
2019 American Transplant Congress
Protection of the Donor Kidney Vascular Endothelium by Ex-Vivo Perfusion with a Pan-Caspase Inhibitor
R. Plenter¹, S. Jain², T. Nydam¹, A. jani²
¹Transplant Microsurgery Program, University of Colorado, Aurora, CO, ²Renal Division, University of Colorado, Aurora, CO
*Purpose: Orthotopic kidney transplantation is a life-saving therapeutic option for patients with end stage organ failure. Pulsatile perfusion (PP) of deceased donor kidneys is increasingly…
2019 American Transplant Congress
Reverse Signaling through CD137 Ligand Promotes Tissue Repair after Ischemia-Reperfusion Kidney Injury
H. R. Cho¹, S. Lee², J. S. Lee³, S. J. Park¹, B. Kwon²
¹Ulsan University Hospital, Ulsan, Korea, Republic of, ²Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, ³Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of
*Purpose: We previously showed that CD137 ligand (CD137L) reverse signaling play a central role in kidney ischemia-reperfusion injury (IRI) by amplifying acute renal injury. In…
2019 American Transplant Congress
Tubastatin-A, an HDAC6 Inhibitor, is Protective in Liver Ischemia Reperfusion Injury and Acetaminophen-Mediated Liver Injury
S. Concors¹, D. Murken¹, P. Hernandez¹, D. Aufhauser¹, Z. Wang¹, G. Ge¹, L. Krumeich¹, T. Bhatti², A. Kozikowski³, W. Hancock², M. H. Levine¹
¹Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA, ³Starwise Therapeutics, Madison, WI
*Purpose: Ischemia reperfusion injury (IRI) causes morbidity and contributes to early graft loss in liver transplantation and no current therapy exists. Liver injury complicates other…
2019 American Transplant Congress
Human Mesenchymal Stem Cells Inhibits Hypoxia-Induced Islets Apoptosis via Regulation of Autophagy
R. Pengfei, X. Yuzhi
The Third Xiang Ya Hospital,Central South University, ChangSha, China
*Purpose: Xenotransplantation of porcine islets has been an emerging and effective option for clinicians to treat type 1 diabetes recently. Comparing with other damage, hypoxic…
2019 American Transplant Congress
Clinical, Aging, Morphometric Measures & Adverse Outcomes in Kidney Transplant Recipients
A. Muzaale¹, N. Chu¹, H. Ying¹, B. Ross², D. Segev¹, M. McAdams-Demarco¹
¹JHU, Baltimore, MD, ²UM, Ann Habor, MI
*Purpose: Sarcopenia is a hallmark of frailty, a geriatric phenotype which is common among kidney transplant (KT) candidates and recipients. Sarcopenic-obesity is a high-risk state…
2019 American Transplant Congress
The Combination of 3-Month Estimated Glomerular Filtration Rate and Proteinuria is a Valuable Tool for Evaluating Long-Term Kidney Graft Survival
C. Mottola¹, N. Girerd², K. Duarte³, A. Aarnink⁴, M. Kessler⁵, L. Frimat⁶, S. Girerd⁶
¹Nephrology and Kidney Transplant Unit, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France, ²Clinical Investigation Center 1433, INSERM U1116, INI-CRCT, F-CRIN, Lorraine University, Vandoeuvre-lès-Nancy, France, ³Clinical Investigation Center 1433, INSERM 1116, INI-CRCT, F-CRIN, Lorraine Univeristy, Vandoeuvre-lès-Nancy, France, ⁴Laboratoire d’Histocompatibilité, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France, ⁵Nephrology and kidney transplant unit, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France, ⁶Nephrology and kidney transplant unit, INI-CRCT, F-CRIN, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France
*Purpose: Estimated glomerular filtration rate (eGFR) measured at 1 year is the usual outcome used to predict the long-term graft survival in the field of…
2019 American Transplant Congress
Absolute Quantification of Micro RNA and Messenger RNA Using a Customized Amplicon in Real Time Quantitative Polymerase Chain Reaction Assays
C. Li, C. Snopkowski, M. Cassidy, B. Botticelli, S. Albakry, J. R. Lee, M. Lubetzky, D. Dadhania, H. Yang, R. Ding, T. Muthukumar, M. Suthanthiran
WCMC, New York, NY
*Purpose: Transcript abundance in biological specimens quantified by RT-PCR assay is typically expressed as fold change between groups. Absolute quantification is preferable to relative quantification…
2019 American Transplant Congress
Molecular Phenotype of Proliferative Arteriopathy in Kidney Grafts
A. Perkowska-Ptasinska¹, M. Ciszek¹, D. Deborska-Materkowska¹, A. Debska-Slizien², P. F. Halloran³, M. Myslak⁴
¹Warsaw Medical University, Warsaw, Poland, ²Gdansk Medical University, Gdansk, Poland, ³University of Alberta, Edmonton AB, AB, Canada, ⁴Pomeranian Medical University, Szczecin, Poland
*Purpose: Proliferative arteriopathy (PA) is a lesion characterized by a fibrotic tissue in the arterial intima. The phenomenon is marked by the lack of elastic…
2019 American Transplant Congress
Should Kidney Retransplants Be Performed From Either Extended Criteria Donor Or Donation After Cardio Circulatory Death Donors?
D. Harriman, V. Gurram, A. Farney, J. Rogers, G. Orlando, C. Jay, A. Reeves-Daniel, A. Mena-Gutierrez, M. Gautreaux, W. Doares, S. Kaczmorski, R. Stratta
Wake Forest Baptist Medical Center, Winston-Salem, NC
*Purpose: Donation after brain death expanded criteria donors (ECD) and donation after cardiocirculatory death (DCD) standard criteria donors (DCD/SCD) increase the donor organ pool but…