2018 American Transplant Congress
Acute Murine CMV Infection Results in Loss of Intragraft CD73HIFR4HIPD1+ CD4 T Cells and Graft Rejection in Previously Tolerant Recipients
Background: Transplantation tolerance in human recipients has been achieved in recent trials. Nevertheless, the impact of highly prevalent and clinically relevant cytomegalovirus (CMV) infection on…2018 American Transplant Congress
Organ-Specific Differences in a Thymoglobulin and Belatacept-Based Protocol for Tolerance Induction in Non-Human Primates
Massachusetts General Hospital, Boston.
In non-human primate lung transplantation, allograft acceptance has been achieved using a delayed mixed-chimerism approach consisting of 4 months of triple-drug immunosuppression followed by donor…2018 American Transplant Congress
Genome-Wide Association Study Assessing Risk of Rejection in Pediatric Transplant Recipients
Background: Rejection risk varies after solid organ transplantation (SOT). We explored genomic variants associated with susceptibility to graft rejection.Methods: SOTs enrolled in a multicenter prospective…2018 American Transplant Congress
Targeting Histone Deacetylase in Renal Tubular Epithelial Cells Inhibits Amplification of TH1 Cell-Mediated Inflammation
Inje University, Busan, Korea.
Background: Objective: More studies are focusing on renal tubular epithelial cells (RTECs) as a new target to restore inflammatory environment as clarifying their immune regulatory…2018 American Transplant Congress
Targeting Lymphotoxin Signaling in Lymphatics Regulates Immune Sensitization, Elicitation, and Resolution
Background:Contact hypersensitivity (CHS) is a T cell-mediated cutaneous inflammatory response which includes three phases of priming/sensitization, elicitation, and resolution,mirroring many aspects of allogeneic responses. The…2018 American Transplant Congress
Hemodynamic and Functional Analysis of Human DCD Hearts Undergoing Normothermic Ex Vivo Perfusion
Massachusetts General Hospital, Boston.
Heart donation after circulatory death (DCD) is feasible although little is known about the hemodynamic and functional parameters of these marginal donor organs. We conducted…2018 American Transplant Congress
MCS and Desensitization
Cedars Sinai Medical Center, Los Angeles.
Purpose: Sensitization prior to heart transplantation (HTx) has been associated with increased mortality and rates of rejection as well as an increased incidence of cardiac…2018 American Transplant Congress
Evaluation of Culture/Preservation Conditions on Human Islet Survival and Function
BackgroundIslet transplantation is an effective treatment for type-1 diabetic patients suffering from severe hypoglycemic episodes. Islet culture or preservation post-isolation has been adopted by various…2018 American Transplant Congress
Does Prolonged Cold Ischemia Affect Outcomes in Donation after Cardiac Death Kidney Transplants?
Surgery, Medicine, Pathology, Pharmacy, Wake Forest Baptist Medical Center, Winston-Salem, NC.
Introduction: Prolonged cold ischemia time (CIT) in the setting of donation after cardiac death (DCD), with requisite warm ischemia time (WIT), produces a 'dual hit'…2018 American Transplant Congress
External Validation of Hennepin Transplant Risk Score for Prediction of Short-Term Mortality and Morbidity after Deceased Kidney Transplantation
Introduction: The additive or synergistic effects of multiple co-morbidities at the time of listing on transplant survival is still unclear. Objective scoring systems predicting post-transplant…
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