2018 American Transplant Congress
Endoplasmic Reticulum Stress Sensor IRE1α Deficiency Promotes Infiltrating Macrophage Polarization and Induces Long-Term Renal Allograft Acceptance in Mice
Objective: Macrophage is involved in the pathogenesis of I/R injury and allograft rejection. However, the mechanisms underlying this is vastly unknown. This study aims to…2018 American Transplant Congress
Effects of IdeS on HLA-SAB, C1q-SAB and CDC-XM
IgG degrading enzyme of Streptococcus pyogenes (IdeS) cleaves human IgG in two steps, first cleaving one of the heavy chains resulting in a single-cleaved IgG…2018 American Transplant Congress
New Onset Diabetes after Kidney Transplant: Comparisons of Risks Associated with Various Steroid-Containing Calcineurin Inhibitor and Sirolimus Regimens
INTRODUCTION: We aimed to examine the risk of new onset diabetes after transplant (NODAT) associated with the following maintenance immunosuppression regimens in kidney transplant recipients…2018 American Transplant Congress
Deceased Pediatric Donor Livers: How Current Policy Drives Allocation and Transplantation
Background:The current liver allocation algorithm for livers from deceased pediatric (<18y; “pedi“) donors prioritizes adults listed locally/regionally over children listed nationally. We sought to understand…2018 American Transplant Congress
Obesity is Not Associated with Worse Outcomes for Type 2 Diabetic Simultaneous Pancreas-Kidney (SPK) Transplant Recipients
Pancreas T2D Subcommittee, UNOS, Richmond.
BACKGROUND: Per current SPK allocation policy, Type 2 Diabetic (T2D) candidate waiting time is contingent on a body mass index (BMI, kg/m2) less than or…2018 American Transplant Congress
Legal Status, Criminal History, and Substance Use in Listing Decisions
Background: Psychosocial criteria constitute absolute and relative contraindications to listing, which can bar patients from access to organ transplantation at a program. Refusing to list…2018 American Transplant Congress
Single-Cell Analysis of Graft Infiltrating T-Cells in Cardiac Allograft Vasculopathy
Medicine, Columbia University Medical Center, New York, NY.
Background: Cardiac allograft vasculopathy (CAV) remains a leading cause of death after heart transplant.T-cells are thought to play a central role, yet the mechanism by…2018 American Transplant Congress
Unraveling the Neuroimmunological Pathways Surrounding Brain Death: Systematic Study of Clinically Relevant Serum Biomarker Changes during Donor Management from Admission to Procurement
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Donation after brain death (BD) remains an important source of transplanted organs worldwide and it has been shown that BD causes a hostile environment with…2018 American Transplant Congress
Tacrolimus Metabolism in Subjects with Potentially Absent CYP3A Activity
Purpose: Tacrolimus (TAC) is a well-known cytochrome P450 (CYP) 3A4 and 3A5 substrate. Common single nucleotide polymorphisms (SNPs) in these genes are significantly related to…2018 American Transplant Congress
Non-Invasive Diagnostic of Renal Allograft Rejection via Urine Metabolites Using NMR-Spectroscopy
Introduction and BackgroundPost-transplant surveillance for acute rejection is typically based on regular monitoring of serum creatinine levels and consecutive biopsies upon functional renal impairment. Attempts…
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