ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    What Happened When the 'Soft Opt-Out' to Organ Donation Was Implemented in Wales? Family and Professional Views and Experiences, and Consent Rates for the First 18 Months

    L. Mc Laughlin, J. Noyes, K. Morgan, P. Walton, A. Roberts, M. Stephens.

    Social Sciences, Bangor University, Bangor, Wales, United Kingdom; Major Health Conditions Policy Team, Welsh Government, Cardiff, Wales, United Kingdom; Organ Donation, NHS Blood and Transplant, Cardiff and Liverpool, Wales, United Kingdom; Nephrology and Transplantation, University Hospital of Wales, Cardiff, Wales, United Kingdom.

    On 01.12.15 Wales introduced a 'soft opt-out' system of organ donation.Co-productive, mixed-methods study partnered with NHS Blood and Transplant and patient and public representatives. Data…
  • 2018 American Transplant Congress

    Medicare Part D Plans Deny Coverage for Off-Label and Off-Compendia Immunosuppressant Use: A Case Series

    L. Potter, E. Garrity.

    Pharmacy, University of Chicago Medicine, Chicago, IL; Pulmonary & Critical Care Medicine, University of Chicago Medicine, Chicago, IL.

    Immunosuppressants are a protected drug class under the Medicare Part D benefit, meaning that all drugs in this class must be present on all plan…
  • 2018 American Transplant Congress

    Upper Limb Transplantation in the US: An Early Look at OPTN Data

    J. Wainright,1 L. Levin,2 C. Wholley,1 W. Cherikh,1 D. Klassen,1 L. Cendales.3

    1United Network for Organ Sharing, Richmond, VA; 2Univ of Pennsylvania, Philadelphia, PA; 3Duke Univ School of Medicine, Durham, NC.

    In July 2014, the OPTN assumed responsibility for developing policy for vascularized composite allotransplantation (VCA). This abstract presents initial data collected in upper limb transplantation…
  • 2018 American Transplant Congress

    Re-Endothelialization of Liver Xenografts Utilizing Human Endothelial Cells

    W. Hassanein,1 P. Patel,1 A. Werdsheim,1 J. Brilliant,1 E. Buckingham,1 N. Shockcor,1 C. Drachenberg,2 R. Barth,1 J. LaMattina.1

    1Surgery, University of Maryland, Baltimore, MD; 2Pathology, University of Maryland, Baltimore, MD.

    Introduction:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Xenograft vascular endothelium represents the initial site…
  • 2018 American Transplant Congress

    Increased Expression of HLA-DPB1 in Pre-Implantation Kidney Biopsies is Associated with Poor Late Graft Function

    K. Mine,1 T. Mourão,1 C. Felipe,2 G. Rampim,1 J. Medina-Pestana,2 H. Tedesco-Silva,2 M. Gerbase-DeLima.1

    1Instituto de Imunogenética, AFIP, São Paulo, Brazil; 2Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil.

    In a previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of 53 deceased donors (GeneChip® Human Gene 1.0 ST Arrays, Affymetrix; GEO…
  • 2018 American Transplant Congress

    Renal Allograft Cortical Perfusion Quantification by 3D-Arterial Spin Labeling Could Be Used to Identify Subclinical Antibody-Mediated Rejection

    W. Wang,1 J. Wen,2 F. Xu,2 Y. Yu,3 L. Zhang,3 Z. Liu.2

    1Nanjing Medical University, Jinling School of Medicine, Nanjing, China; 2Jinling Hospital, Nanjing University School of Medicine, National Clinical Research Center of Kidney Diseases, Nanjing, China; 3Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

    Background: Antibody-mediated rejection (AMR) is now the most principal post-surgical complication complicating allograft long-term survival. Therefore, its early detection before serum creatinine rises/estimated glomerular filtration…
  • 2018 American Transplant Congress

    Psychosocial Assessment of Candidates for Transplantation (PACT) Identifies Non-Adherence in Pediatric Kidney Transplantation

    K. Freischlag,1 V. Chen,2 S. Nagaraj,2 A. Chua,2 E. Chambers.2

    1School of Medicine, Duke University, Durham, NC; 2Pediatrics, Duke University, Durham, NC.

    Background: We have demonstrated that overall pre-transplant Psychosocial Assessment of Candidates for Transplantation (PACT) scores can identify high risk pediatric kidney recipients. In this pilot…
  • 2018 American Transplant Congress

    Everolimus and the Risk of Graft Loss or Death in Kidney Transplant Recipients: A Trial-Based Linkage Study

    T. Ying,1,2 G. Wong, W. Lim, G. Russ, H. Pilmore, J. Kanellis, D. Goodman, P. Trevillian, S. Campbell, M. Suranyi, M. Mathew, R. Faull, R. Masterson, R. Walker, P. O'Connell, S. Chadban.1,2

    1Renal Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; 2Kidney Node, Charles Perkins Centre, University of Sydney, Sydney, Australia.

    Background: The use of mTORIs may be associated with a reduction of cancer incidence after kidney transplantation (KT) and improved graft function compared with calcineurin-inhibitor…
  • 2018 American Transplant Congress

    Assessment of Peak Levels and Metabolism Rates in African American (AA) and Non-AA Kidney Transplant Recipients (KTR) on Immediate-Release Tacrolimus (IR-tac)

    T. Horwedel,1 R. Sodhi,2 D. Tsapapas,3 M. Mills,4 S. Patel,4 G. Towns.5

    1Barnes-Jewish Hospital, St. Louis, MO; 2St. Louis University, St. Louis, MO; 3Columbia University, New York, NY; 4Veloxis Pharmaceuticals, Cary, NC; 5University of Alabama, Birmingham, AL.

    Trough-to-daily dose (C/D) ratio has been used as a simple method for evaluation of IR-tac metabolism rate. Recent studies have shown that fast metabolizers defined…
  • 2018 American Transplant Congress

    Development of Optimal Simplified Equation for Estimation of Mycophenolic Acid Exposure Following Enteric-Coated Mycophenolate Sodium Administration in Chinese Renal Transplant Recipients

    W. Peng, C. Tian, Z. Chen, W. Xue, G. Wang, Q. Ye, X. Zhang, M. Gu, M. Zhao, C. Wang, C. Huang, J. Yan, W. Zhang, C. Ding, Y. Fu, S. Ye, X. Hu, R. Tan, M. Li, R. Deng, Y. Ke, W. Wu, M. Fan, J. Chen.

    MyERA Study Group, Hangzhou, China.

    Background: Limited sampling strategies (LSS) aids in overcoming the complexity of extensive PK sampling and supporting the calculation of mycophenolic acid (MPA) exposure. This study…
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