ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Prediction of Hepatocellular Carcinoma Recurrence Following Liver Transplantation Using Combined Differential Gene Expression, Copy Number Variation and Somatic Mutation Analysis

    A. Humar,1 P. Liu,2 J. Luo,3 M. Nalesnik,3 A. Singhi,3 G. Tseng,2 G. Michalopoulos.3

    1Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA; 2Biostatistics, University of Pittsburgh, Pittsburgh, PA; 3Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.

    Liver allocation for transplant candidates with hepatocellular carcinoma is limited by OPTN policy to patients whose tumors remain within size limits defined by Milan criteria.…
  • 2018 American Transplant Congress

    Comparison of No Kasai Portoenterstomy to Failed Kasai: Analysis of UNOS Database

    T. Miloh, K. Hosek, S. Harpavath.

    Texas Children's Hospital/Baylor College of Medicine, Houston.

    IntroductionInfants with biliary atresia (BA) identified “later” (typically after 90 days of life) present a management challenge, as late Kasai portoenterostomy (KP) has high failure…
  • 2018 American Transplant Congress

    Efficacy and Safety of Immediate- and Prolonged-Release Tacrolimus in De Novo Pediatric Transplantation: Randomized Study

    K. Vondrak,1 F. Parisi,2 A. Dhawan,3 R. Grenda,4 N. Webb,5 S. Marks,6 D. Debray,7 R. Holt,8 A. Lachaux,9 D. Kelly,10 G. Kazeem,11 N. Undre.11

    1University Hospital Motol, Prague, Czech Republic; 2Osp Pediatrico Bambino Ges[ugrave], Rome, Italy; 3King's College Hospital, London, United Kingdom; 4The Children's Memorial Health Institute, Warsaw, Poland; 5Manchester University Foundation Trust, Manchester, United Kingdom; 6Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; 7APHP-Hôpital Universitaire Necker, Paris, France; 8Alder Hey Children's Hospital, Liverpool, United Kingdom; 9Université Lyon 1 et Hospices Civils de Lyon, Lyon, France; 10Birmingham Children's Hospital, Birmingham, United Kingdom; 11Astellas Pharma Europe Ltd, Chertsey, United Kingdom.

    This study assessed long-term efficacy/safety of prolonged-release tacrolimus (PR-T) vs immediate-release tacrolimus (IR-T) in de novo pediatric transplant pts. Phase II, parallel-group, multicenter, open-label study…
  • 2018 American Transplant Congress

    Is BMI > 35 a Barrier to Kidney Transplantation?

    D. Walczak, E. Benedetti, C. Ryan.

    Organ Transplant, University of Illinois, Chicago, IL.

    Background:Although lower rates of patient and graft survival are reported for kidney transplant recipients with BMI > 35, kidney transplant in this group provides a…
  • 2018 American Transplant Congress

    Increasing Obesity and Diabetes Prevalence in the United States End-Stage Renal Disease Population

    B. Shelton,1 D. McWilliams,1 P. MacLennan,1 R. Reed,1 M. Mustian,1 D. Sawinski,2 J. Locke.

    1Surgery, University of Alabama at Birmingham, Birmingham, AL; 2Medicine, University of Pennsylvania, Philadelphia, PA.

    Background: Obesity and diabetes have both become national epidemics in the United States, and are associated with increased risk for comorbid diseases including end-stage renal…
  • 2018 American Transplant Congress

    An Economic Analysis of the UK Pancreas Allocation Scheme

    K. Burke,1 S. Birch,2,3 T. Augustine.1

    1The Renal and Pancreas Transplantation Unit, Manchester Royal Infirmary, Manchester, United Kingdom; 2Centre for Health Economics, University of Manchester, Manchester, United Kingdom; 3Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada.

    Introduction: Economics provides input to decisions concerning the best use of available resources. In transplantation, limitations include organ availability and competing organ demands. This is…
  • 2018 American Transplant Congress

    Demand for Uterine Transplantation in the United States: Initial Recruitment Results of a Trial of Uterine Transplantation in the Northeast U.S.

    P. Porrett,1 N. Latif,2 E. Wang,2 L. Sortor,3 S. Levin,4 A. Shaked,1 K. Olthoff,1 C. Coutifaris,2 D. Driscoll,2 K. O'Neill.2

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2OB/Gyn, University of Pennsylvania, Philadelphia, PA; 3Psychiatry, University of Pennsylvania, Philadelphia, PA; 4Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA.

    Background Uterine factor infertility (UFI) may affect 7 million women in the United States. Uterine transplantation (UTx) is an emerging treatment for UFI, particularly in…
  • 2018 American Transplant Congress

    The Effect of Intravenous Immunoglobulin on In Vitro Human Antibody Binding to Genetically-Engineered Pig Cells – Relevance to Clinical Xenotransplantation –

    T. Yamamoto,1 Q. Li,1 H. Iwase,1 D. Ayares,2 D. Cooper,1 H. Hara.1

    1Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham; 2Revivicor, Blacksburg.

    Background: Xenoreactive antibodies play an important role in xenograft rejection. Intravenous immunoglobulin (IVIG), which has anti-complement activity and contains anti-idiotypic antibodies, is widely used for…
  • 2018 American Transplant Congress

    Increased Expression of HLA-DPB1 in Pre-Implantation Kidney Biopsies is Associated with Poor Late Graft Function

    K. Mine,1 T. Mourão,1 C. Felipe,2 G. Rampim,1 J. Medina-Pestana,2 H. Tedesco-Silva,2 M. Gerbase-DeLima.1

    1Instituto de Imunogenética, AFIP, São Paulo, Brazil; 2Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil.

    In a previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of 53 deceased donors (GeneChip® Human Gene 1.0 ST Arrays, Affymetrix; GEO…
  • 2018 American Transplant Congress

    Renal Allograft Cortical Perfusion Quantification by 3D-Arterial Spin Labeling Could Be Used to Identify Subclinical Antibody-Mediated Rejection

    W. Wang,1 J. Wen,2 F. Xu,2 Y. Yu,3 L. Zhang,3 Z. Liu.2

    1Nanjing Medical University, Jinling School of Medicine, Nanjing, China; 2Jinling Hospital, Nanjing University School of Medicine, National Clinical Research Center of Kidney Diseases, Nanjing, China; 3Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

    Background: Antibody-mediated rejection (AMR) is now the most principal post-surgical complication complicating allograft long-term survival. Therefore, its early detection before serum creatinine rises/estimated glomerular filtration…
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