Am J Transplant, Volume 18, Suppl 3 Archives - Page 141 of 211 - ATC Abstracts

2018 American Transplant Congress
Endothelin-1 Type A Receptor Antibodies Are Associated with Elevated Il-8, Arteritis and Decline in Renal Function in Pediatric Renal Transplant Recipients
M. Pearl,¹ J. Grotts,¹ M. Rossetti,¹ Q. Zhang,¹ P. Weng,¹ E. Reed,¹ E. Tsai Chambers.²
¹University of California, Los Angeles, Los Angeles, CA; ²Duke University, Durham, NC.
Background: We have recently shown that the non-HLA antibody, AT1R-Ab, is prevalent and associated with poor outcomes in pediatric kidney transplant recipients (KTRs). The prevalence…
2018 American Transplant Congress
Impact of Changes to the LAS Calculation
R. Lehman,¹ R. Carrico,¹ K. Uccellini,¹ K. Chan,² T. Whelan.³
¹United Network for Organ Sharing, Richmond, VA; ²Univ of Michigan, Ann Arbor, MI; ³Medical Univ of South Carolina, Charleston, SC.
Purpose: On 2/19/2015 major revisions to the Lung Allocation Score (LAS) calculation were made to more appropriately reflect candidates' waiting list urgency and post-transplant survival.…
2018 American Transplant Congress
Human Thrombomodulin Expression on Genetically Modified Donor Pigs is Required to Maintain the Anti-Coagulation Profile
A. Singh, L. DiChiacchio, J. Chan, P. Corcoran, B. Lewis, M. Thomas, D. Ayares, K. Horvath, M. Mohiuddin.
CSRP/NHLBI and DVR/ORS, NIH, Bethesda, MD; Revivicor Inc., Blacksburg, VA; Dept of Surgery, University of Maryland, Baltimore, MD.
Introduction: Coagulation dysregulation is major limitation for xenotransplantation but it is resolved to some extent by making genetically engineered (GE) pigs, which express complement inhibitors…
2018 American Transplant Congress
Treatment Outcomes of Recurrent Primary Focal Segmental Glomerulosclerosis (FSGS) after Kidney Transplantation
R. Aguiar,¹ F. Pereira,² A. Gasparini,³ P. Chowdhury,¹ D. Game,¹ D. Moutzouris.¹
¹Department of Nephrology and Transplantation, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom; ²Department of Renal Medicine, Hospital Dr. Fernando Fonseca, Lisbon, Portugal; ³Department of Health Sciences, University of Leicester, Leicester, United Kingdom.
Introduction: Primary FSGS can recur in the renal allograft and is associated with poor graft outcomes. There is no established therapeutic intervention to prevent or…
2018 American Transplant Congress
Precision Medicine for Determining the Efficacy of a Novel Belatacept Regimen
J. Shoji, J. Leung, E. Tavares, Q. Tang, F. Vincenti.
Transplant Nephrology, UCSF, San Francisco, CA.
IntroBelatacept is increasingly used as maintenance immunosuppression to improve long term outcomes in kidney transplant. Since acute rejection in patients on belatacept have been noted…
2018 American Transplant Congress
Use of Proton-Pump Inhibitors is Associated with Lower Magnesium and Iron Status and Excess Mortality in Renal Transplant Recipients
A. Gomes-Neto,¹ R. Douwes,¹ M. Eisenga,¹ S. Berger,¹ R. Gans,¹ E. Berg,¹ G. Navis,¹ H. Blokzijl,² S. Bakker.¹
¹Nephrology, UMCG, Groningen, Netherlands; ²Gastroenterology and Hepatology, UMCG, Groningen, Netherlands.
BackgroundProton-pump inhibitor (PPI) use is common in renal transplant recipients (RTR). However, PPI use may induce micronutrient deficiencies and has been associated with increased mortality…
2018 American Transplant Congress
Worsening Racial/Ethnic Disparities in Pediatric Kidney Transplant Outcomes in the US
T. Purnell, X. Luo, L. Cooper, D. Crews, K. Covarrubias, A. Massie, D. Segev.
Johns Hopkins, Baltimore.
Purpose: We recently demonstrated narrowed racial/ethnic disparities in adult kidney transplant (KT) outcomes in the US. The goal of this study was to examine twenty-year…
2018 American Transplant Congress
Elevated Serum Penteraxin in Cardiac Allograft Antibody Mediated Rejection: From Cytokine Arrays to Patients with ABMR
O. Moussa,³ M. Kavarana,² L. Klingman,¹ J. Felius,¹ S. Hall,¹ M. Askar.¹
¹Baylor Research Institute, Dallas; ²Medical University of South Carolina, Charleston; ³University of Michigan, Ann Arbor, MI.
Pentraxin 3 (PTX3) is soluble protein that has been implicated in in atherosclerosis, endothelial function, hypertension, myocardial infarction and angiogenesis (Fornai et al., 2016). We…
2018 American Transplant Congress
Prospective, Multi-Center Observational Study of Cell-Mediated Immunity for Cytomegalovirus Infection in Kidney Transplant Recipients
D. Kumar,¹ P. Chin-Hong,² L. Kayler,³ D. Wojciechowski,⁴ A. Limaye,⁵ O. Gaber,⁶ S. Ball,⁷ A. Mehta,⁸ T. Blanchard,⁹ C. Kotton.⁴
¹UHN, Toronto, Canada; ²UCSF, San Francisco; ³ECMC, Buffalo; ⁴MGH, Boston; ⁵UOWMC, Seattle; ⁶WCMC, Houston; ⁷UHB, Birmingham, United Kingdom; ⁸EmoryU, Atlanta; ⁹Oxford Diag, Marlborough.
Background:T-cell-mediated immunity (CMI) is crucial for the control of CMV infection post-transplant. We evaluated a novel EliSpot assay to determine whether CMI results could predict…
2018 American Transplant Congress
Resuscitation and Viability Testing of Initially Declined Livers Using Sequential Hypo- and Normothermic Machine Perfusion with an Acellular Fluid
Y. de Vries,^1,2 A. Matton,^1,2 S. Karangwa,^1,2 M. Nijsten,³ R. de Kleine,² A. van den Berg,⁴ V. de Meijer,² P. Meyer,⁵ M. de Boer,² R. Porte.²
¹Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; ²Section of HPB Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, Netherlands; ³Department of Critical Care, University Medical Center Groningen, Groningen, Netherlands; ⁴Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands; ⁵Department of Anesthesiology, University Medical Center Groningen, Groningen, Netherlands.
While end-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) resuscitates mitochondria and reduces ischemia-reperfusion injury, normothermic machine perfusion (NMP) allows for ex-situ functional testing of donor…