2018 American Transplant Congress
Characterization of Viral and Host Cell Genomic Alterations in EBV+ PTLD
1Abdominal Transplant, Stanford University, Stanford; 2Pathology, Stanford University, Stanford.
Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation characterized by abnormal proliferation of lymphoid cells in the setting of immunosuppression after…2018 American Transplant Congress
Risk Factors and Outcomes with Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Bloodstream Infections among Solid Organ Transplant Recipients
Objective: Solid organ transplant recipients (SOTR) have been significantly impacted by the emergence of multidrug-resistant bacteria, including extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (EB). We determined the…2018 American Transplant Congress
MERTK Mediates Transplant Tolerance via IFN-a Regulation of MDSCs and Tregs
Northwestern University Feinberg School of Medicine, Chicago.
Introduction: MERTK is one of the TAM receptor tyrosine kinases (RTKs) that mediate homeostatic phagocytosis of apoptotic cells, and transmit regulatory signals that modulate immune…2018 American Transplant Congress
Pilot Study of Plasma Cell Niche-Targeted Therapy for Enhancement of Proteasome Inhibitor Effectiveness
1UCincinnati, Cincinnati; 2Cincinnati Children's, Cincinnati; 3Duke, Durham.
HLA antibody (Ab)-secreting bone marrow (BM) plasma cell (PC) survival depends on niche occupancy via a CXCR4 (PC)-CXCL12 (BM stromal cell) interaction. Plerixafor inhibits CXCR4-CXCL12…2018 American Transplant Congress
The Effect of Perioperative Antiplatelet/Anticoagulant Therapy on the Incidence of Early Postoperative Thromboembolic Complications and Bleeding in Kidney Transplantation – A Dual Center Retrospective Cohort Study of 2000 Kidney Transplant Recipients
Thromboembolic complications (TECs) are dreaded complications after kidney transplantation (KTx). Consequences are severe and can result in delayed graft function or even graft loss. Perioperative…2018 American Transplant Congress
Survival Benefit of Partial Grafts in Pediatric Candidates with Acute Liver Failure Awaiting Liver Transplantation: SRTR Analysis over 26 Years
Objective: Pediatric fulminant hepatic failure (PFHF) is a devastating condition which portends a poor prognosis without liver transplantation (LT). In comparison to adult candidates, there…2018 American Transplant Congress
Declining Number of Pancreas after Kidney Transplants Despite Significant Improvement in Outcome
1SUNY Downstate Medical Center, Brooklyn, NY; 2SUNY Upstate Medical University, Syracuse, NY.
Introduction: The number of whole organ pancreas transplants declined significantly over the past 15 years. The largest decrease was seen in pancreas after kidney (PAK)…2018 American Transplant Congress
Taking Your Center's Temperature: Using a Heat Map to Target Your Transplant-Specific Education for Regulatory Compliance
Medical University of South Carolina, Charleston.
Background: Large, multi-organ transplant centers struggle with implementation of a comprehensive strategy for development and execution of a Transplant-specific education plan. Regulatory requirements for staff…2018 American Transplant Congress
Allogeneic T Follicular and T Conventional Responses Assessed by Proliferation, Cytokine Production, and TCR Clonality
1Thomas E. Starzl Transplantation Institute, Pittsburgh; 2Adaptive Biotechnologies, Seattle.
Background: Human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. Our previous analysis showed that allo-reactive precursors were present in…2018 American Transplant Congress
Trends in Liver Transplantation with Older Liver Donors in the United States
As the US population ages, older liver donors (OLDs) represent a potential expansion of the donor pool. Historically, grafts from OLDs have been associated with…
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