2017 American Transplant Congress
Antidepressant Medication Use Before and After Kidney Transplant: Implications for Post-Transplant Outcomes.
Limited data are available on the implications of antidepressant medication use in kidney transplant recipients.We examined a novel database wherein national transplant registry identifiers for…2017 American Transplant Congress
In Vivo Administration of Plerixafor in Humans Mobilizes Bone Marrow Resident Plasma Cells That Demonstrate Apoptosis in Both Bone Marrow and Peripheral Blood.
1University of Cincinnati, Cincinnati; 2Cincinnati Children's, Cincinnati; 3Duke, Durham
Plasma-cell (PC) targeted therapies can reduce HLA sensitization. However, bone marrow (BM) niche resident plasma cells (BMNRPC) demonstrate resistance to proteasome inhibitor (PI) therapy. Plerixafor…2017 American Transplant Congress
Harnessing Scientific and Technological Advances to Improve Equity in Kidney Allocation Policies.
To increase the likelihood of finding a compatible donor, kidney allocation systems prioritize highly sensitized patients to counterbalance the impact of HLA allo-sensitization and preclude…2017 American Transplant Congress
Preliminary Results of Clinical Normothermic Ex Vivo Liver Perfusion in a North American Setting.
Outcomes of a first clinical normothermic machine perfusion (NMP) UK liver trial demonstrated feasibility and clear safety, with improved liver function when compared to standard…2017 American Transplant Congress
Truth in Pathology: Autopsy Findings in Lungs Declined for Transplantation.
Healthy lungs are scarce among available organ donors who are becoming progressively older and have increasing numbers of comorbidities. Selection criteria that include excellent oxygenation…2017 American Transplant Congress
Changes in Peripheral Blood Gene Expression Profile After Calcineurin Inhibitor (CNI) Withdrawal in Kidney Transplant Recipients.
CNI are effective in kidney transplantation but their off-target effects make CNI withdrawal (w/d) desirable. Published studies showed that clinical parameters cannot differentiate the ~50%…2017 American Transplant Congress
The Gut Microbiota Regulates Murine Cardiac Transplant Outcome.
Background: Gut microbiota regulates systemic immunity and can activate pro- or anti-inflammatory pathways. We hypothesized that the gut microbiota influences the survival of mismatched murine…2017 American Transplant Congress
MHC Class II-Peptide Complexes Displayed on Activated T Cells Guide Treg Suppression.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Background: Regulatory T cell (Tregs) therapy remains a promising strategy for minimizing immunosuppression and extending allograft survival. Although Treg suppression requires initial activation through cell…2017 American Transplant Congress
Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection.
Antibody-mediated rejection (AMR) is a major determinant of heart allograft loss. However, the specific effects of anti-HLA antibodies on heart allograft injury have not been…2017 American Transplant Congress
Impact of Donor BK-Virus Replication on Posttransplant BKV Replication After Living-Donor Transplantation.
Department of Nephrology and Organ Transplantation, Toulouse University Hospital, Toulouse, France
BK-virus-associated nephropathy (BKVAN) can cause kidney-allograft dysfunction after kidney transplantation: several risk factors for BKV replication after kidney transplantation have been identified. They can be…
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