Am J Transplant, Volume 17, Suppl 3 Archives - Page 70 of 181 - ATC Abstracts

2017 American Transplant Congress
Impact of mTOR-Inhibition on Tolerance-Induction Following Heart Transplantation.
M.-T. Dieterlen, K. Klaeske, J. Fischer, J. Hahn, K. Jawad, J. Garbade, F. Mohr, S. Lehmann.
Clinic for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
Introduction: The mammalian target of rapamycin (mTOR) is a central regulator of the immune system and therefore one target of immunosuppressive drug therapy. Tolerance-inducing properties…
2017 American Transplant Congress
Normothermic Donor Lung Preservation with Portable EVLP Significantly Reduces Ischemia/Reperfusion Injury in Lung Recipients by Promoting Cytokine Antagonists.
C. Falk,¹ B. Wiegmann,² C. Neudörfl,¹ C. Kühn,² I. Tudorache,² M. Wvsar,² A. Haverich,² G. Warnecke.²
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Department of Cardiothoracic Transplant and Vascular Surgery, MHH, Hannover, Germany
ObjectivesThe INSPIRE trial revealed significant reduction of PGD grade 3 using the Organ Care System (OCS) compared to the standard of care (SOC) for lung…
2017 American Transplant Congress
Clinical Risk Factors for Bronchiolitis Obliterans Syndrome (BOS) in Lung Transplant Recipients (LTRs): Results of an International Cohort Study.
N. Law,¹ B. Hamandi,¹ C. Fegbeutel,² F. Silveira,³ E. Verschuuren,⁴ P. Ussetti,⁵ P. Chin-Hong,⁶ A. Solé,⁷ C.-L. Holmes-Liew,⁸ E. Billaud,⁹ P. Grossi,¹⁰ O. Manuel,¹¹ D. Levine,¹² R. Barbers,¹³ D. Hadjiliadis,¹⁴ L. Singer,¹ S. Husain.¹
¹University Health Network, Toronto, ON, Canada; ²Hannover Medical School, Hannover, Germany; ³University of Pittsburgh, Pittsburgh, PA; ⁴University Medical Center Groningen, University of Groningen, Groningen, Netherlands; ⁵Hospital Puerta de Hierro, Madrid, Spain; ⁶University of California, San Francisco, CA; ⁷University and Polytechnic Hospital La Fe, Universidad de Valencia, Valencia, Spain; ⁸Royal Adelaide Hospital, Adelaide, Australia; ⁹APHP Hopital Européen G Pompidou, Paris, France; ¹⁰University of Insubria, Varese, Italy; ¹¹University Hospital of Lausanne, Lausanne, Switzerland; ¹²University of Texas Health Science Center San Antonio, San Antonio, TX; ¹³KECK Medical Center of University of Southern California, Los Angeles, CA; ¹⁴University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, PA
Introduction:Bronchiolitis obliterates syndrome (BOS) is a major impediment in the long term survival of LTRs. The main objective of this study was to identify infectious…
2017 American Transplant Congress
Liver Retransplantation: The Largest Post MELD Single Center Experience.
F. Kaldas, I. Korayem, V. Agopian, T. Russell, S. Ebaid, A. Zarrinpar, H. Yersiz, D. Farmer, R. Busuttil.
Surgery, University of California Los Angeles, Los Angeles, CA
OBJECTIVE: Analyze post MELD liver retransplantation (Re-OLT) and identify recipient and donor preoperative risk factors associated with poor patient outcomes.BACKGROUND: Re-OLT is a high risk…
2017 American Transplant Congress
A Non-Invasive Urinary Common Rejection Module (uCRM) Gene Expression Score Quantifies and Differentiates Kidney Transplant Injury.
T. Sigdel,¹ J. Yang,¹ O. Bestard,² S.-C. Hsieh,¹ S. Roedder,² I. Damm,¹ J. Liberto,¹ S. Nandoe,¹ M. Sarwal.¹
¹University of California San Francisco, San Francisco; ²Immucor Inc, Atlanta
We sought to investigate the use of the common rejection module (CRM) genes in the discrimination of AR, BKVN, and stable transplant phenotypes in urine…
2017 American Transplant Congress
Results of the Initial Phase of the Portable Organ Care System (OCS™) Liver PROTECT Pivotal Trial.
J. Markmann,¹ M. Ghobrial,³ J. Magliocca,⁴ A. Demetris,⁵ M. Abouljoud.²
¹Department of Surgery-Division of Transplantation, Massachusetts General Hospital, Boston, MA; ²Transplant Institute and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ³Sherrie & Alan Conover Center for Liver Disease & Transplantation, Houston Methodist Hospital, Houston, TX; ⁴Division of Transplant Surgery Department of Surgery, The Emory Transplant Center, Atlanta, GA; ⁵Department of Transplant Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
PurposeThe OCS Liver PROTECT Trial is a prospective, international, randomized controlled trial to evaluate the impact of using portable ex-vivo warm, oxygenated blood perfusion using…
2017 American Transplant Congress
Rapid Depletion of Circulating DSA and Treatment of Acute Antibody-Mediated Rejection with the Combination of CTLA-4Ig/Belatacept and Bortezomib in Mouse and Man.
J. Young,¹ A. Vannier,¹ G. Bumgardner,² A. Chong,¹ R. Pelletier.²
¹Sugery, University of Chicago, Chicago, IL; ²Surgery, The Ohio State University, Columbus, OH
Antibody mediated rejection (AMR) is a major cause of rejection, and there are limited therapeutic options for reversing alloantibody production when it is fully established.…
2017 American Transplant Congress
Sulfatide-Selective NKT Cells Mediate M2 to M1 Polarization Resulting in Amelioration of Kidney Fibrosis.
S. Lee,¹ M.-Y. Yu,² Y. Kim,² S. Yang,¹ S. Han,¹ H. Lee,² J. Lee,³ D. Kim,² Y. Kim.²
¹Seoul National University Hospital Biomedical Researh Institute, Seoul, Republic of Korea; ²Seoul National University Hospital, Seoul, Republic of Korea; ³Seoul National University Boramae Medical Center, Seoul, Republic of Korea
Background: Macrophage subtype polarization has been suggested as a key player related to kidney fibrosis. Moreover, myofibroblast, the principal cells that produce extracellular matrix in…
2017 American Transplant Congress
Five-Year Outcomes After Transplantation of Kidneys from Deceased Donors with Acute Kidney Injury.
J. Latona,¹ A. Shah,^1,2 A. Frank,^1,2 W. Maley,^1,2 C. Doria,^1,2 C. Ramirez.^1,2
¹Division of Transplant Surgery, Thomas Jefferson University, Philadelphia, PA; ²Kidney Transplant Program, Lankenau Medical Center, Wynnewood, PA
Background: Kidneys from deceased donors with acute kidney injury (AKI) are often discarded due to a perceived higher risk of poor graft function. Kidney Donor…
2017 American Transplant Congress
The Clinical and Economic Burden of Pneumonia in Canadian Solid Organ Transplant Recipients.
N. Law,¹ B. Hamandi,² A. Alghamdi,¹ E. Papadimitropoulos,² S. Husain.¹
¹Multi Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Department of Pharmacy, University Health Network, Toronto, ON, Canada
Introduction:Due to the limited amount of health resources available, there is a need for health program and economic evaluation to inform stakeholders about optimum resource…