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American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Accelerated Rejection of Secondary Third Party Allografts in Older Recipients Is Facilitated by an Augmented Innate Immune Response.

    T. Heinbokel, K. Minami, A. Elkhal, S. Tullius.

    Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Accumulating evidence acknowledges the central relevance of aging and chronic antigen exposure in shaping the balance of innate and adaptive immunity. Here, we assessed whether…
  • 2017 American Transplant Congress

    Ambulatory Antibiotic Utilization and Outcomes in an Adult Kidney Transplant Population: A Pharmacovigilance Analysis.

    L. Avery, C. Fominaya, R. Crawford, D. Taber.

    Pharmacy, Ralph H Johnson VAMC, Charleston, SC

    Antibiotics (abx) are commonly prescribed to kidney transplant (KTX) recipients in the outpatient setting. There is limited data assessing the safety and outcomes associated with…
  • 2017 American Transplant Congress

    Use of Ledipasvir/Sofosbuvir with or without Ribavirin in Patients Post-Liver Transplant: Evaluation of Real-World Datasets.

    S. Flamm,1 M. Charlton,2 M. Manns,3 M. Prieto,4 I. Fernandez,5 M. Londono,6 R. Kwok,7 C. Smith,8 S. Lee,9 H. Ngo,9 A. Osinusi,9 A. Copans,9 L. Rossaro,9 M. Shoreibah,10 O. Massoud,10 M. Curry,11 M. Bourliere.12

    1Northwestern University, Chicago; 2Intermountain Medical Center, Murray; 3Hannover Medical School, Hannover, Germany; 4Hospital Universitari I Politecnic La Fe, Valencia, Spain; 5Hospital Universitario 12 de Octubre, Madrid, Spain; 6Servicio de Hepatología. Hospital Clinic, Barcelona, Spain; 7Walter Reed National Military Medical Center, DC; 8Medstar Georgetown University Hospital, Georgetown; 9Gilead Sciences, Inc., Foster City; 10University of Alabama Birmingham, Birmingham; 11Beth Israel Deaconess Medical Center, Boston; 12Hospital Saint Joseph, Marsielle, France

    PURPOSE: Post-liver transplant(LT) patients with HCV are considered a difficult-to-treat population. Ledipasvir/sofosbuvir(LDV/SOF) +ribavirin(RBV) for 12 weeks is approved in GT1 LT recipients based on the…
  • 2017 American Transplant Congress

    HCV+ Waitlist Candidates More Likely to Die Waiting for Kidney Transplant from HCV- Donor.

    B. Shelton,1 D. Sawinski,2 S. Mehta,1 R. Reed,1 P. MacLennan,1 J. Locke.1

    1University of Alabama at Birmingham, Birmingham; 2University of Pennsylvania, Philadelphia

    Background: HCV-infected ESRD patients derive a significant survival benefit from kidney transplantation (KT) over remaining on dialysis. Given the high mortality rates on dialysis and…
  • 2017 American Transplant Congress

    Access to Simultaneous Pancreas and Kidney Transplant (SPK) Should Not Be Restricted to BMI > 28.

    M. Laftavi, A. Gruessner, V. Whittaker, Z. Acun, O. Pankowycz, R. Gruessner.

    SUNY Upstate Medical University, Syracuse, NY

    Background: Currently, UNOS guidelines require that uremic, insulin-dependent type 1 diabetic patients have a body mass index (BMI) < 28m/kg2 in order to be eligible…
  • 2017 American Transplant Congress

    Tolerant Pediatric Liver Transplant (LT) Recipients (TOL) from WISP-R (NCT00320606) Split into Two Phenotypically Distinct Groups by PD1 Expression on CD4+ T Cells at Baseline, Prior to Immunosuppression Withdrawal (ISW).

    B. Burrell,1 S. Feng,2 N. Bridges,3 U. Ekong,4 S. Kanaparthi,1 A. Kirk,5 A. Long,1 K. Spain,6 L. Stempora,5 L. Turka,1 N. Tchao.1

    1ITN, Bethesda; 2UCSF, San Francisco; 3NIAID, Bethesda; 4Yale, New Haven; 5Duke, Durham; 6Rho, Chapel Hill

    Background: Combinations of cell surface markers such as PD1, CD57, and/or KLRG1 identify T cells that may fail to respond to cognate antigen challenge –…
  • 2017 American Transplant Congress

    Acute Mouse CMV Infection Abrogates Transplant Tolerance by Modulating Myeloid Cell Differentiation and Function: A Possible Role for Transcription Factor RORγt.

    A. Dangi,1 L. Zhang,1 X. Zhang,2,3 Z. Zhang,2,3 X. Luo.1,2,3

    1Nephrology and Hypertension, Northwestern University, Chicago, IL; 2Comprehensive Transplant Center, Northwestern University, Chicago, IL; 3Comprehensive Transplant Center, Northwestern University, Chicago, IL

    Cytomegalovirus (CMV) infection has long been associated with graft-dysfunction and rejection in transplant-recipients. Nevertheless, precise understanding of underlying molecular mechanisms remains unclear. Here, we investigated…
  • 2017 American Transplant Congress

    BK Virus Infection and Risk of Urinary Tract Cancers Among Kidney Transplant Patients in the Transplant Cancer Match Study.

    G. Gupta,1 S. Kuppachi,2 R. Kalil,2 C. Buck,3 C. Lynch,2 E. Engels.3

    1Virginia Commonwealth University, Richmond; 2University of Iowa, Iowa City; 3National Cancer Institute, Bethesda

    Background: Recent case series describe expression of BK virus (BKV) in tumor tissue obtained from renourinary cancers in kidney transplant recipients (KTRs). Thus, BKV may…
  • 2017 American Transplant Congress

    Employment Patterns After Kidney Transplantation: Rates, Contributing Factors, and Outcomes.

    J. Kim, J. Rana, M. Ashwin, Y. Li, O. Famure.

    Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada

    Background: The costs of productivity lost in transplant patients poses a concern, as a significant number of patients are of working age. Furthermore, healthcare and…
  • 2017 American Transplant Congress

    Increased Long-Term Mortality 20 years After Living Kidney Donation.

    G. Mjoen,1 S. Hallan,2 H. Holdaas.1

    1Dpt of Transplantation, Rikshospitalet, Oslo, Norway; 2Dpt of Nephrology, St. Olavs Hospital, Trondheim, Norway

    Living kidney donors are healthy at the time of donation. Consequently, a long observation period is necessary to detect possible detrimental effects of donation. Most…
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