2017 American Transplant Congress
Challenges for the Travelling Donor: Variability Between Donor Work-Up and Donor Surgery in the Canadian Kidney Paired Donation Program.
Background: A primary obstacle to providing renal transplantation is limited access to donated kidneys. The living donor pool for renal allografts was greatly expanded through…2017 American Transplant Congress
Urinary Type III Procollagen (PIIINP) Is Associated with Chronic Allograft Dysfunction and Predicts Graft Survival.
Background: Chronic allograft dysfunction (CAD) is the most important clinical problem in solid organ transplantation. Interstitial fibrosis and tubular atrophy contribute to long term renal…2017 American Transplant Congress
Allograft Crescent Predicts Graft Failure in Recurrent IgA Nephropathy Patients.
Seoul National University Hospital, Seoul, Korea
Background A recent multicenter study demonstrates predictive value of crescents in native IgA nephropathy (IgAN), however it remains unclear whether allograft crescent is associated with…2017 American Transplant Congress
The New Kidney Allocation System: The Effect on Elderly Transplantation in the US. Review of UNOS Database.
Surgery, State University New York, Syracuse, NY
The New Kidney Allocation System(KAS) improve access disadvantaged groups. The effect on the elderly population, recipients >=65 is unknown.Methods: Retrospective analysis of UNOS database preKAS…2017 American Transplant Congress
A Novel KPD Mechanism to Increase Transplants When Some Candidates Have Multiple Willing Donors.
1Carnegie Mellon U, Pittsburgh; 2U of Maryland, College Park; 3UNOS, Richmond; 4Yale U, New Haven
Purpose: Current kidney exchanges such as the OPTN Kidney Paired Donation (KPD) program allow candidates to list multiple willing donors, but only one will donate…2017 American Transplant Congress
Dual Targeting with Carfilzomib and Tocilizumab Abrogates Antibody-Mediated Rejection and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation.
Duke University Medical Center, Durham, NC; Cedars-Sinai Medical Center, Los Angeles, CA
Purpose:Sensitized recipients have poor access to kidney transplantation (KT) and worse outcomes when transplanted. We have shown that bortezomib inhibits plasma cells (PCs), but does…2017 American Transplant Congress
Impact of T-Cell Depletion on CMV-Specific Memory T and B Cell Homeostatic Proliferation After Kidney Transplantation.
Human CMV infection is the most common opportunistic infection after kidney transplantation, with a negative impact on kidney allograft outcome. Transplant recipients are at higher…2017 American Transplant Congress
Glycolytic and Glutaminolytic Metabolism Supports IL-15 Induced Inflammatory Response of Temra CD8 from Kidney Transplant Recipients.
1CRTI UMR1064, INSERM, Nantes, France; 2CRCNA UMR892, INSERM, Nantes, France
Rational. We have recently shown that the accumulation of TEMRA CD8 in kidney transplant recipients (Tx) is associated with a higher risk of kidney dysfunction.…2017 American Transplant Congress
Clinical and Histopathologic Features of Antibody Mediated Rejection (ABMR) in Highly Sensitized (HS) vs Non-Sensitized (NS) Pediatric Renal Transplant Recipients.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Background: The presence of preformed donor-specific antibody (pDSA) in HS pts and development of de-novo DSA (dnDSA) in NS patients are risk factors for ABMR.…2017 American Transplant Congress
Efficacy and Safety of Everolimus with Reduced Tacrolimus or Cyclosporine in Pediatric Liver Transplant Recipients: 12-Month Results from H2305 Study.
1H2305 Study Group, St Louis; 2Novartis Pharma AG, Basel, Switzerland
Purpose: Everolimus (EVR) facilitated calcineurin inhibitor (CNI) reduction has shown improved renal function (RF) without compromising efficacy in adult liver transplant recipients (LTxR). Here we…
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