Am J Transplant, Volume 17, Suppl 3 Archives - Page 57 of 181 - ATC Abstracts

2017 American Transplant Congress
The Phenotypic and Functional Characteristics of a Novel CD11b⁺CD11c⁺F4/80⁺ Monocytic Myeloid-Derived Suppressor Cell Subset.
B. Jiang,^1,2 I. Aljabban,¹ C. Yang,¹ D. Ndishabandi,¹ R. White,¹ P. Russell,¹ J. Madsen,¹ R. Colvin,¹ A. Alessandrini.¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston; ²Dept. of Cardiac Surgery, Second Xiangya Hospital, Central South University, Changsha, China
Background: CD11b+Ly6G-Ly6Chigh monocytic myeloid-derived suppressor cells (M-MDSCs) in mice can promote the apoptosis of T cells and induce regulatory T cells. Novel CD11b+CD11c+F4/80+ cells were…
2017 American Transplant Congress
C5b-9 Deposition in Glomerular Capillaries Is Responsible for Poor Allograft Survival in Antibody-Mediated Rejection.
V. Goutaudier,¹ H. Perrochia,¹ M. Marron-Wojewodzki,¹ F. Garo,¹ C. René,¹ N. Pirot,² G. Mourad,¹ M. Le Quintrec.¹
¹University Hospital, Montpellier, France; ²Cancer Research Institute, Montpellier, France
Introduction: C4d (scare of C4 cleavage) deposition in peritubular capillaries (PTC), a marker of complement activation, is associated with antibody-mediated rejection (AMR) in kidney transplantation.…
2017 American Transplant Congress
Type 1 Diabetic Patients Have Better Endothelial Function After Simultaneous Pancreas-Kidney Transplantation Than After Kidney Transplantation with Continued Insulin Therapy.
A. Kolonko,² A. Kowalik,¹ J. Ziaja,¹ D. Kaminska,³ A. Owczarek,⁴ A. Kujawa-Szewieczek,² M. Kusztal,³ J. Badura,¹ D. Bozek-Pajak,¹ A. Zakrzewska,⁵ P. Choreza,⁴ R. Krol,¹ S. Chlopicki,⁵ M. Klinger,³ A. Wiecek,² J. Chudek,⁶ L. Cierpka.¹
¹Medical University of Silesia, Katowice, Poland; ²Medical University of Silesia, Katowice, Poland; ³Wroclaw Medical University, Wroclaw, Poland; ⁴Medical University of Silesia, Sosnowiec, Poland; ⁵Jagiellonian University, Krakow, Poland; ⁶Medical University of Silesia, Katowice, Poland
Objective: The improvement of blood glucose metabolism in type 1 diabetic (T1D) patients after simultaneous pancreas-kidney transplantation (SPK) is anticipated to slow progression of vascular…
2017 American Transplant Congress
Procurement Kidney Biopsy versus KDRI for Predicting Graft Survival.
I. Hall,¹ C. Parikh,² B. Schröppel,³ F. Weng,⁴ Y. Jia,² H. Thiessen-Philbrook,² P. Reese,⁵ M. Doshi.⁶
¹University of Utah, Salt Lake City, UT; ²Yale University, New Haven, CT; ³University Hospital, Ulm, Germany; ⁴Saint Barnabas Medical Center, Livingston, NJ; ⁵University of Pennsylvania, Philadelphia, PA; ⁶Wayne State University, Detroit, MI
Background: The kidney donor risk index (KDRI) incorporates 10 variables to match organ quality with expected recipient survival. Though controversial, procurement biopsies are often performed…
2017 American Transplant Congress
Donor Batf3-Dependent Dendritic Cells Initiate Acute Rejection in a Skin Transplantation Model.
T. Borges, N. Murakami, L. Riella.
Schuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Donor skin dendritic cells (DCs) play a crucial role in providing allospecific signal to host T cells either by direct interaction of donor MHC with…
2017 American Transplant Congress
Evaluation of Cytomegalovirus Prophylaxis Regimens in Intestinal Transplant Recipients: A Single Center Experience.
M. Eley,¹ M. Keck,¹ D. Collier,² M. Vacha.¹
¹Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE; ²College of Pharmacy: Department of Pharmacy Practice, University Of Nebraska Medical Center, Omaha, NE
Purpose: To evaluate the incidence of cytomegalovirus (CMV) infection in intestinal transplant recipients after a change in an antiviral regimen.Methods: This was a retrospective review…
2017 American Transplant Congress
IL-21R Antagonist Inhibits Differentiation of B Cells Towards Plasmablasts upon Alloantigen Stimulation.
K. de Leur,^1,2 F. Dor,⁴ M. Dieterich,¹ L. van der Laan,² R. Hendriks,³ C. Baan.¹
¹Internal Medicine, Erasmus MC, Rotterdam, Netherlands; ²Surgery, Division HPB and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands; ³Pulmonary Medicine, Erasmus MC, Rotterdam, Netherlands; ⁴Imperial College Healthcare NHS Trust, London, United Kingdom
Background: Antigen-specific antibody responses rely on IL-21+ T follicular helper (Tfh) cells that regulate B cell differentiation. In transplantation, a large proportion of renal allograft…
2017 American Transplant Congress
At-Home Transplant Education Increases Black and Low-Income Dialysis Patients' Transplant Knowledge, Attitudes, Informed Decision-Making, and Pursuit: An Explore Transplant @ Home Randomized Controlled Trial.
A. Waterman,¹ J. Peipert,¹ A.-M. McSorley,¹ C. Goalby,¹ L. Peace.²
¹UCLA, Los Angeles, CA; ²Missouri Kidney Program, Columbia, MO
Black and low-income dialysis patients, who face greater barriers to kidney transplant (KT), may need additional educational support. This randomized controlled trial (RCT) assessed the…
2017 American Transplant Congress
Optimization of Pancreatic Islet-Like Clusters from hiPSCs for Cell Therapy in Type 1 Diabetes.
G. Pettinato, P. Kyriazis, M. Thompson, M. Koulmanda, R. Fisher.
Surgery, Beth Israel Deaconess Medical Center, Boston, MA
IntroductionTreatment for Type 1 Diabetes (T1D) includes pancreas or islets of Langerhans transplantation. Pancreatic beta-like cells from differentiated human induced pluripotent stem cells (hiPSCs) offer…
2017 American Transplant Congress
Acute Cellular Rejection Is Associated with Increased Risk of Early and Late Graft Failure.
A. Massie, J. Garonzik-Wang, D. Segev.
JHU, Baltimore
The association between acute cellular rejection and subsequent early and late graft loss has not been well-quantified.METHODS: Using SRTR data and Cox regression, we studied…