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American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    HOPE Act – The First Year.

    A. Wilk, S. Taranto, R. Urban, D. Klassen.

    United Network for Organ Sharing, Richmond, VA

    Background: The HIV Organ Policy Equity (HOPE) Act, enacted on 11/21/13, allows for research on transplants of kidneys (KI) or livers (LI) from HIV+ donors…
  • 2017 American Transplant Congress

    Beyond the Bones – The Association Between Vitamin D, Graft Outcomes, Malignancy and Vascular Disease.

    A. Seitz,1 A. Cherukuri,2 R. Baker.1

    1Renal Unit, St James's Hospital, Leeds, West Yorkshire, United Kingdom; 2UPMC, Pittsburgh, PA

    Introduction: Vitamin D deficiency in kidney transplant recipients (KTRs) is an emerging theme. The purported associations between Vitamin D deficiency and various metabolic, cardiovascular and…
  • 2017 American Transplant Congress

    Forty-Six Consecutive Cases of Pure Live Donor Right or Extended Right Hepatectomy: Single Surgeon Initial 1-Year Experience.

    S. Hong, K.-S. Suh, H.-S. Kim, S.-W. Ahn, K. Yoon, D. Oh, H. Kim, N.-J. Yi, K.-W. Lee.

    Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea

    The pure laparoscopic live donor hepatectomy has been performed in several experienced transplant centers. However, short and long-term surgical outcomes are not yet to be…
  • 2017 American Transplant Congress

    Early Evolution and Immunopathologic Phenotype of Treg-Rich Organized Lymphoid Structures (TOLS) Associated with Immunological Tolerance in Accepted Mouse Kidney Allografts.

    C. Yang,1 I. Rosales,2 E. Farkash,3 D. Ndishabandi,1,3 R. White,3 P. Russell,1 J. Madsen,1 A. Alessandrini,1,3 R. Colvin.1,3

    1Center for Transplantation Sciences, Mass General Hospital, Boston, MA; 2Department of Pathology, Mass General Hospital, Boston, MA; 3Department of Pathology, University of Michigan, Ann Arbor, MI

    Introduction: Lymphoid neogenesis has been found in allografts after organ transplant. We previously reported that spontaneously accepted DBA/2 to B6 kidney allografts developed distinctive, peri-arterial…
  • 2017 American Transplant Congress

    Early and Late Antibody Mediated Rejection and Mixed Acute Rejection Are Clinically Distinct and Demonstrate Biologic Differences in Immunodominant Donor Specific Antibody Characteristics.

    A. Lichvar,1 E. Portwood,1 P. Brailey,1 S. Tremblay,1 A. Shields,2 A. Govil,1 M. Cardi,2 M. Cuffy,1 R. Alloway,1 A. Girnita,1 E. Woodle.1

    1U of Cincinnati, Cincinnati; 2The Christ Hospital, Cincinnati

    Early and late antibody mediated rejection (AMR) and mixed acute rejection (MAR) possibly result from fundamentally different immunologic processes. DSA mediates direct injury by complement-dependent…
  • 2017 American Transplant Congress

    Benefits of Induction in Recipients of Acute Renal Failure Donor Kidneys.

    M. Barrett, A. Smith, K. Woodside, R. Sung.

    University of Michigan, Ann Arbor

    Kidneys from donors with acute renal failure (ARF) are often discarded due to concerns for DGF and graft failure. Induction immunosuppression can be used to…
  • 2017 American Transplant Congress

    Procurement Kidney Biopsy versus KDRI for Predicting Graft Survival.

    I. Hall,1 C. Parikh,2 B. Schröppel,3 F. Weng,4 Y. Jia,2 H. Thiessen-Philbrook,2 P. Reese,5 M. Doshi.6

    1University of Utah, Salt Lake City, UT; 2Yale University, New Haven, CT; 3University Hospital, Ulm, Germany; 4Saint Barnabas Medical Center, Livingston, NJ; 5University of Pennsylvania, Philadelphia, PA; 6Wayne State University, Detroit, MI

    Background: The kidney donor risk index (KDRI) incorporates 10 variables to match organ quality with expected recipient survival. Though controversial, procurement biopsies are often performed…
  • 2017 American Transplant Congress

    Donor Batf3-Dependent Dendritic Cells Initiate Acute Rejection in a Skin Transplantation Model.

    T. Borges, N. Murakami, L. Riella.

    Schuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Donor skin dendritic cells (DCs) play a crucial role in providing allospecific signal to host T cells either by direct interaction of donor MHC with…
  • 2017 American Transplant Congress

    Evaluation of Cytomegalovirus Prophylaxis Regimens in Intestinal Transplant Recipients: A Single Center Experience.

    M. Eley,1 M. Keck,1 D. Collier,2 M. Vacha.1

    1Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE; 2College of Pharmacy: Department of Pharmacy Practice, University Of Nebraska Medical Center, Omaha, NE

    Purpose: To evaluate the incidence of cytomegalovirus (CMV) infection in intestinal transplant recipients after a change in an antiviral regimen.Methods: This was a retrospective review…
  • 2017 American Transplant Congress

    IL-21R Antagonist Inhibits Differentiation of B Cells Towards Plasmablasts upon Alloantigen Stimulation.

    K. de Leur,1,2 F. Dor,4 M. Dieterich,1 L. van der Laan,2 R. Hendriks,3 C. Baan.1

    1Internal Medicine, Erasmus MC, Rotterdam, Netherlands; 2Surgery, Division HPB and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands; 3Pulmonary Medicine, Erasmus MC, Rotterdam, Netherlands; 4Imperial College Healthcare NHS Trust, London, United Kingdom

    Background: Antigen-specific antibody responses rely on IL-21+ T follicular helper (Tfh) cells that regulate B cell differentiation. In transplantation, a large proportion of renal allograft…
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