Am J Transplant, Volume 17, Suppl 3 Archives - Page 57 of 181 - ATC Abstracts

2017 American Transplant Congress
Regional Variation in Liver Donor Utilization Across the U.S.
A. Friedman,¹ P. Bagavan,² S. Florman,³ H. Irving,¹ B. Samstein,⁴ B. Schleich.¹
¹LiveOnNY, New York, NY; ²Binghamton University, Binghamton, NY; ³Recanati/Miller Transplant Institute, New York, NY; ⁴Weill Cornell Medical College, New York, NY
Unequal patient access to deceased donor liver transplantation across the U.S. has generated efforts to redesign the allocation system. Geographic disparities include the severity of…
2017 American Transplant Congress
Outcomes of Moderately to Severely Steatotic Grafts in Liver Transplantation: A Meta-Analysis.
K. Bonner,¹ C. Thongprayoon,² W. Cheungpasitporn,¹ M. Leise.¹
¹Mayo Clinic, Rochester; ²Bassett Medical Center, Cooperstown
Background/Objectives:There is a worldwide need to expand the pool of available liver grafts. Livers with >50% steatosis are discarded for orthotopic liver transplantation (OLT) by…
2017 American Transplant Congress
Impact of Early Pancreas Graft Failure on Patient and Kidney Graft Survival After Simultaneous Pancreas and Kidney Transplantation (SPK).
A. Gruessner, M. Laftavi, V. Whittaker, Z. Acun, O. Pankowycz, R. Gruessner.
SUNY Upstate Medical University, Syracuse, NY
Introduction: In SPK transplants, the major risk factors for poor patient survival are early pancreas and/or kidney graft loss. In this study, we specifically examined…
2017 American Transplant Congress
BK Virus in Simultaneous Pancreas Kidney Transplantation.
P. Uva,^1,2 L. Leon,¹ E. Minue,¹ A. Dotta,¹ F. Toniolo,¹ R. Pilotti,¹ E. Chuluyan,² D. Casadei.¹
¹Instituto de Nefrología de Buenos Aires - Nephrology, Buenos Aires, Argentina; ²CEFyBO - CONICET, Buenos Aires, Argentina
BK virus (BKV) may produce nephropathy that could lead to graft failure. The most effective treatment is to decrease immunosuppression (IS). In simultaneous pancreas kidney…
2017 American Transplant Congress
Donor and Recipient Views on Their Relationship in Living Kidney Donation: Thematic Synthesis of Qualitative Studies.
A. Ralph,^1,2 P. Butow,¹ C. Hanson,^1,2 S. Chadban,^1,3 J. Chapman,¹ J. Craig,^1,2 J. Kanellis,⁴ G. Luxton,⁵ A. Tong.^1,2
¹University of Sydney, Sydney, Australia; ²Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia; ³Royal Prince Alfred Hospital, Sydney, Australia; ⁴Monash University, Melbourne, Australia; ⁵University of New South Wales, Sydney, Australia
Background: Many donors and recipients report an improved relationship after transplant, however tension, neglect, guilt and proprietorial concern over the recipient can impede donor and…
2017 American Transplant Congress
Chimerism-Related Allotolerance Is Induced by Exosome Acquisition and Reprogramming of Host Dendritic Cells.
D. Lema,¹ W. Bracamonte-Baran,² E. Jankowska-Gan,¹ F. Claas,³ J. van Rood,³ A. Mulder,³ W. Burlingham.¹
¹Surgery - Transplant Division, University of Wisconsin-Madison, Madison, WI; ²Pathology, Division of Immunology, Johns Hopkins University, Baltimore, MD; ³Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands
Maternal microchimerism (MMc) has been associated with allo-specific graft tolerance in mice and humans. This tolerance is associated with membrane allo-antigen acquisition (mAAQ), which is…
2017 American Transplant Congress
Blocked of Bat3 Expression Promotes Transplant Tolerance by Inducing IL-10 Expression in Dendritic Cells.
G. Gu, H. Hang, Q. Xia.
Department of Hepatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Objective: To explore the effect of Bat3 on DCs during transplant tolerance induction.Methods: Allogeneic heart transplants were performed between WT and Bat3flox/floxCD11c-Cre+ mice, to test…
2017 American Transplant Congress
MERTK Mediates Transplantation Tolerance via Inhibition of TBK1 Phosphorylation and IFN-a Production.
L. Zhang,¹ M. DeBerge,² X. Zhang,³ J. Wang,³ Z. Zhang,³ E. Thorp,² X. Luo.^1,2,3
¹Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, IL; ²Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL; ³Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL
Introduction: The TAM (Tyro3, Axl and MERTK) receptor tyrosine kinases (RTKs) mediate homeostatic phagocytosis of apoptotic cells, and transmit regulatory signals that modulate immune response.…
2017 American Transplant Congress
Immunosuppressive Role of Pancreas Derived Mesenchymal Stem Cells.
M. Kanak,¹ F. Kunnathodi,² M. Levy,^1,3 M. Lawrence,² B. Naziruddin.⁴
¹Transplant Surgery, Virginia Commonwealth University, Richmond, VA; ²Baylor Research Institute, Dallas, TX; ³Hume-Lee Transplant Center, VCU Health System, Richmond, VA; ⁴Simmons Transplant Institute, Baylor Scott and White Health, Dallas, TX
BackgroundThe Edmonton protocol revived islet transplantation therapy for Type-1 Diabetic patients. However, Long-term islet function still remains a challenge. Immunosuppression used after islet transplantation contributes…
2017 American Transplant Congress
Identification of Plasma Protein Biomarkers of Acute Renal Allograft Rejection.
M. Rossetti,¹ C. Fitzpatrick,¹ N. Harre,¹ Y. Zheng,¹ N. Mercer,² G. Sunga,¹ D. Gjertson,¹ E. Reed.¹
¹Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA; ²Department of Biostatistics, University of California Los Angeles, Los Angeles, CA
Background & Aim: Upon presentation of clinical symptoms, renal transplant recipients routinely undergo needle core biopsy to diagnose acute graft rejection. This procedure is invasive…