ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Poor Predictability of Quantiferon-TB Assay in Recipients and Donors for Tuberculosis Development After Kidney Transplantation in an Intermediate-TB-Burden Country.

    J. Yang,1 J. Ryu,1 J. Jang,2 J.-G. Lee,2 C. Ahn.1

    1Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea; 2Transplantation Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

    Background. Tuberculosis (TB) is a common opportunistic infection after kidney transplantation (KT). Quantiferon-TB Gold In-Tube test (QFT) is widely used for assessing latent TB; however,…
  • 2017 American Transplant Congress

    Poor Outcome of Polyomavirus -Associated Nephropathy with Glomerular Parietal Epithelial Cells Infected by Polyomavirus.

    G. Huang,1 W. Chen,2 J. Qiu,1 X. Chen,1 L. Chen,1 C. Wang.1

    1Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; 2Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    Background: Bowman's capsular epithelium infected by polyomavirus(Py) in polyomavirus -associated nephropathy (PyVAN) is infrequent and considered as the advanced stage of the disease. The aim…
  • 2017 American Transplant Congress

    Minor Degree of Persistent Microscopic Hematuria in Potential Living Kidney Donors Is Associated with Pathology.

    V. Kumar,1 M. Saha,1 J. Locke,2 R. Gaston,1 M. Hanaway.2

    1Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham; 2Surgery, University of Alabama at Birmingham, Birmingham

    Purpose: A threshold of ≥3 rbc/hpf (red blood cells/high power field) or higher prompts additional testing when evaluating potential living kidney donors at most centers…
  • 2017 American Transplant Congress

    Risk Factors and 2 Year Outcomes of Low Estimated Glomerular Filtration Rate in the Immediate Post-Operative Period for Living Kidney Donors.

    H. Pahari,1 S. Nagai,1 K. Takahashi,1 F. Tinney,2 J. Denny,1 L. Malinzak,1 M. Rizzari,1 K. Collins,1 A. Yoshida,1 M. Abouljoud,1 D. Kim.1

    1Henry Ford Hospital, Detroit; 2Wayne State University, Detroit

    Background: While long-term risk of end-stage renal disease in living kidney donors is considered less than 0.25% at 15 years, an association between the immediate…
  • 2017 American Transplant Congress

    Vendor to Center in 0-60: A Cost-Effective Blueprint for Creating an In-House On-Call System for Abdominal Organ Offers.

    J. Davenport, D. Cassidy, A. Hauser, A. Milling, K. Driggers, H. Crego, J. Anderson, L. Curry, P. Baliga, N. Pilch, D. Dubay.

    Transplant, Medical University of South Carolina, Charleston, SC

    Introduction: Our center decided to return to an in-house nurse coordinator on-call program 7/2016 after using a vendor from 11/2012 to 7/2016 for organ allocation.…
  • 2017 American Transplant Congress

    Incidence of Cytomegalovirus Infection Among Liver Transplant Recipients Maintained on a Cyclosporine vs. Tacrolimus-Based Immunosuppression Regimen.

    C. Burrelli, M. Bradley, S. Pouch, E. Elkhammas, H. Winters.

    The Ohio State University Wexner Medical Center, Columbus, OH

    Background: Cytomegalovirus (CMV) is the most common viral pathogen that affects patient outcomes after liver transplant. Potent immunosuppressive agents predispose patients to an increased risk…
  • 2017 American Transplant Congress

    Low Incidence of Acute Rejection within the Six Months After Transplantation in HIV Recipients Treated with Raltegravir, the ANRS 153 Treve Trial.

    M. Matignon,1 A. Lahiani,9 J. Lelievre,2 D. Desvaux,6 K. Abassi,9 A. Diallo,9 M. Peraldi,7 A. Taburet,4 J. Saillard,5 C. Delaugerre,3 L. Assoumou,9 P. Grimbert,1 TREVE ANRS Study Group.5

    1Nephrology, APHP Henri Mondor, Créteil, France; 2Immunology, APHP Henri Mondor, Créteil, France; 3Virology, APHP Saint Louis, Paris, France; 4Pharmacology, APHP, Le Kremlin-Bicêtre, France; 5ANRS, Paris, France; 6Anatomopathology, APHP Henri Mondor, Créteil, France; 7Nephrology, APHP Saint Louis, Paris, France; 8UMR_S 1136, Paris, France

    Renal transplantation is safe and effective in HIV patients with end stage renal disease (ESRD). High rates of acute rejection (AR) have been reported because…
  • 2017 American Transplant Congress

    Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.

    J. Erfe,1,2 C. Yang,1 D. Ndishabandi,1 I. Rosales,1 R. White,1 P. Russell,1 R. Colvin,1 J. Madsen,1 A. Alessandrini.1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; 2Yale School of Medicine, New Haven, CT

    Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…
  • 2017 American Transplant Congress

    TGF-β1 Induces Transplant Kidney Interstitial Fibrosis Through Endothelial-to-Mesenchymal Transition via TGF-β/Smad and Akt/mTOR/p70S6K Pathways.

    Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.

    Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

    Background: Chronic allograft dysfunction (CAD) induced by kidney interstitial fibrosis is the main cause of allograft failure in kidney transplantation. Studies suggested that endothelial-to-mesenchymal transition…
  • 2017 American Transplant Congress

    Two Promoter Polymorphisms in the Genes Encoding for Complement Regulating Proteins CD46 and CD59 in Kidney Donors Are Associated with Biopsy Proven Acute Rejection.

    L. Michielsen,1 A. van Zuilen,1 T. Kardol-Hoefnagel,2 M. Verhaar,1 H. Otten.2

    1Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, Netherlands; 2Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    BackgroundComplement regulating proteins, including CD46, CD55 and CD59, protect cells against self-damage. Because of their expression on the donor endothelium, they are hypothesized to be…
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