ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    CD8+ TAb-supp Cells Suppress the Production of Multiple Alloantibody Isotypes in Response to MHC-Mismatched Cellular and Vascularized Allografts.

    J. Zimmerer, C. Avila, S. Elzein, B. Ringwald, G. Bumgardner.

    Surgery, The Ohio State University Wexner Medical Center, Columbus, OH

    We have reported that a CD8+ T cell subset, we termed CD8+ TAb-supp cells, inhibits the production of alloAb after hepatocyte transplant (HcTx) in part…
  • 2017 American Transplant Congress

    Dramatic Shifts in Prognosis, Outcomes and Baseline Risk Among Wait Listed Kidney Transplant Candidates in the United States.

    J. Schold, E. Poggio, L. Buccini, S. Flechner, J. Augustine, D. Goldfarb.

    Cleveland Clinic, Cleveland, OH

    Introduction and MethodsOver the past decades there have been numerous clinical advances and policy changes affecting candidates for kidney transplantation. Our aim was to evaluate…
  • 2017 American Transplant Congress

    Belatacept Conversion in Kidney Recipients with Low GFR Does Not Improve Renal Function.

    D. Abdelwahab,1 S. Byron,2 B. Kaplan,1 R. Heilman.1

    1Transplant, Mayo Clinic, Scottsdale, AZ; 2Biostatistics and Informatics, Mayo Clinic, Rochester, MN

    Background:Belatacept interferes with signal 2 of T cell activation via blockade CD80/86 which doesn't adversely impact renal function. We tested a hypothesis that Belatacept conversion…
  • 2017 American Transplant Congress

    Clinical Outcomes of ABO and HLA Incompatible Kidney Transplantation – Nationwide Cohort Study.

    E. Ko,1,2 J. Yu,1,2 C. Yang,1,2 B. Chung,1,2 Korean Organ Transplantation Registry (KOTRY).

    1Transplantation Research Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; 2Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

    Background This is a nationwide cohort study to investigate the impact of anti-A/B antibody or donor specific anti-HLA antibody (HLA-DSA) on the clinical outcomes in…
  • 2017 American Transplant Congress

    Accumulating Mitochondrial DNA in Aging Augments Inflammatory Responses Subsequent to IRI.

    M. Seyda,1,2 M. Quante,1 T. Heinbokel,1 G. Liu,1 H. Uehara,1 J. Schuitenmaker,1 R. Abdi,3 C. Falk,2 A. Elkhal,1 S. Tullius.1

    1Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston; 2Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany; 3Renal Division, Schuster Family Transplant Center, Brigham and Women's Hospital, Boston

    Background: Older donor organs are increasingly utilized to close the gap between demand and supply. We submit that aging-associated kinetics of damage associated molecular patterns…
  • 2017 American Transplant Congress

    Tissue Transcriptional Profile of Portal Inflammation with Interface Activity in Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests Closely Resembles T Cell Mediated Rejection (TCMR).

    A. Sanchez-Fueyo, S. Feng, A. Demetris, J. Bucuvalas, J. Lozano, J. Magee, K. Spain, S. Kanaparthi, iWITH Investigators.

    KCL, London, United Kingdom; UCSF, SF; Pittsburgh, Pittsburgh; Cincinnati, Cincinnati; CiberEHD, Barcelona, Spain; Michigan, Ann Arbor; Rho, Chapel Hill; ITN, Bethesda; NIDDK/NIAID/NIH, Bethesda

    Background: Significant inflammation±fibrosis is frequently seen in biopsies (bxs) of pediatric LT recipients with normal liver tests assessed for immunosuppression withdrawal. The pathogenesis of these…
  • 2017 American Transplant Congress

    Graft Immunocomplex Capture Fluorescence Analysis to Detect Donor Specific Antibodies and HLA Antigen Complexes in the Renal Allograft.

    T. Nakamura,1 H. Ushigome,1 K. Watabe,2 Y. Imanishi,2 S. Harada,1 S. Nobori,1 K. Masuda,1 N. Yoshimura.1

    1Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Department of Blood Transfusion and Cell Therapy, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Background: Immunocomplex Capture Fluorescence Analysis (ICFA) is an attractive method to detect donor specific anti-HLA antibodies (DSA) and HLA antigen complexes. Currently, antibody-mediated rejection (AMR)…
  • 2017 American Transplant Congress

    C3d-Binding Anti-DQ DSA Is Associated with a High Risk for Late ABMR and Graft Failure in Stable Kidney Transplant Recipients.

    D. Lee,1 B. Kim,2 J. Kim,3 I. Kim,4 M. Chun.5

    1Medicine, Maryknoll Medical Center, Busan, Republic of Korea; 2Laboratyory Medicine, Maryknoll Medical Center, Busan, Republic of Korea; 3Surgery, Maryknoll Medical Center, Busan, Republic of Korea; 4Urology, Maryknoll Medical Center, Busan, Republic of Korea; 5Pathology, Maryknoll Medical Center, Busan, Republic of Korea

    Introduction:Donor specific anti-HLA antibodies (DSA) are a major cause of antibody-mediated rejection (ABMR) and poor graft outcome in kidney transplant recipients (KTR). Critical issue is…
  • 2017 American Transplant Congress

    Inflammatory Conditions Dictate the Effect of MSC on B Cell Function.

    F. Luk,1 L. Carreras-Planella,2 S. Korevaar,1 S. de Witte,1 F. Borràs,2 M. Betjes,1 C. Baan,1 M. Hoogduijn,1 M. Franquesa.1,2

    1Nephrology and Transplantation, Dept. of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands; 2Nephrology and Transplantation, Institut d'Investigació Germans Trias i Pujol, Badalona, Spain

    The immunomodulatory capacity of mesenchymal stem or stromal cells (MSC) makes them a promising therapeutic tool for immune disease and organ transplantation. The effects of…
  • 2017 American Transplant Congress

    Avoidance or Reduction of Rituximab Might Improve Clinical Outcomes in ABO-Incompatible Renal Transplantation: Advantages and Disadvantages of Rituximab.

    M. Okada,1 Y. Watarai,1 K. Iwasaki,2 K. Murotani,3 T. Hiramitsu,1 M. Tsujita,1 N. Goto,1 S. Narumi,1 T. Kobayashi.2

    1Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; 2Renal Transplant Surgery, Aichi Medical University, Nagakute, Japan; 3Clinical Research Center, Aichi Medical University, Nagakute, Japan

    BACKGROUNDPretransplant desensitization with rituximab has contributed to drastic improvements in ABO-incompatible renal transplantation (ABO-I). However, ABO-I outcomes are still worse than those of ABO-identical or…
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