2017 American Transplant Congress
Cell-Subset Diversity in Adipose Derived Regenerative Cells Used in Renal Ischemic Reperfusion Injury Treatment.
Studies in our novel hybrid model of transplantion/ischemic reperfusion injury (IRI) in rat has demonstrated significant improvement in kidney function post injection of adipose-derived regenerative…2017 American Transplant Congress
Immune Tolerance Monitoring in Renal Allograft Tolerance Induced by Transient Mixed Chimerism in Nonhuman Primates.
Center for Transplant Science, Massachusetts General Hospital, Boston, MA
Background: We have previously reported donor specific expansion of regulatory T cells (Tregs) in nonhuman primate (NHP) recipients which achieved renal allograft tolerance after induction…2017 American Transplant Congress
Lipid Catabolism Provides Alternative Energy Source and Compensates for Mitochondrial Dysfunction in Reperfused Rat Kidneys After Ischaemia.
Introduction: To reduce morbidity and mortality on the wait list for kidney transplantation, centres are required to use older and higher risk organs including unstable…2017 American Transplant Congress
Cytotopic Thrombin Inhibition Prior to Cold Ischaemia Attenuates Microvascular Endothelial Ischaemia-Reperfusion Injury.
1Imperial College, London, United Kingdom; 2King's College, London, United Kingdom
Purpose: Microvascular dysfunction post-reperfusion of the ischaemic endothelium manifests as cellular necrosis and enhanced endothelial permeability. Thrombin generation post-reperfusion of the ischaemic endothelium may be…2017 American Transplant Congress
Personalized Tacrolimus (TAC) Dosing Using Genetic Variants in Caucasian Kidney Transplant (Tx) Recipients.
TAC is an immune suppressant with a narrow therapeutic index and high pharmacokinetic (PK) variability leading to uncertainty in blood concentrations. We previously developed an…2017 American Transplant Congress
Impact of Polymorphisms of UGT 1 A9 on the Prognosis of Renal Transplant Patients. Association with Digestive Tumors.
Nephrologist, Hospital Clinico San Carlos, Madrid, Spain
The aim of this study was to evaluate the distribution of UGT1A9 promoter region T-275A and C-2152T single nucleotide polymorphisms (SNPs) in stable transplant patients…2017 American Transplant Congress
Influence of Tacrolimus Metabolism Rate on Patients' Survival After Renal Transplantation.
Introduction: Tacrolimus (Tac) is an integral part of the immunosuppressive regimen after renal transplantation (RTx). A fast Tac metabolism rate defined as the Tac blood…2017 American Transplant Congress
The IL6/Th17 Pathway May Play Different Roles in Cell-Mediated and Antibody-Mediated Alloimmune Injury in Renal Allografts.
Purpose. IL6 has been shown to contribute to shifting the balance between tolerogenic regulatory T cells and proinflammatory Th17 cells towards the latter. Our study…2017 American Transplant Congress
Detection of Right Ventricular Dilation and Dysfunction by Transthoracic Echocardiography Predicts Renal Transplant Outcomes.
1Wayne State University School of Medicine, Detroit, MI; 2University of Michigan, Ann Arbor, MI
Introduction: The prevalence of pulmonary hypertension (PHTN) among end stage renal disease (ESRD) patients on hemodialysis is approximately 40-50%. Right heart catheterization is the gold…2017 American Transplant Congress
A Single Center Retrospective Review of Pediatric Kidney Transplant Outcomes According to Banff Grade and Cellular Rejection Treatment.
Acute cellular rejection (ACR) remains a major cause of graft dysfunction and loss. There is limited data to provide guidance on optimal treatment strategies stratified…
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