Am J Transplant, Volume 17, Suppl 3 Archives - Page 3 of 181 - ATC Abstracts

2017 American Transplant Congress
Cumulative Deficits Frailty Index for Transplant Candidates Predicts Candidacy for Solid Organ Transplantation.
R. Varughese,^1,2 O. Theou,³ X. Huang,¹ O. Famure,¹ Y. Li,¹ N. Chowdhury,¹ E. Renner,^1,2 J. Kim,^1,2 J. MacIver,^1,5 S. Mathur,⁴ K. Rockwood,³ L. Singer.^1,2
¹Toronto Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Department of Medicine, University of Toronto, Toronto, ON, Canada; ³Department of Medicine, Dalhousie University, Halifax, NS, Canada; ⁴Department of Physical Therapy, University of Toronto, Toronto, ON, Canada; ⁵Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada
Introduction: Frailty is a clinical state associated with decreased function and increased vulnerability to physiologic stressors, leading to adverse medical outcomes. The cumulative deficits model…
2017 American Transplant Congress
HOPE Act – The First Year.
A. Wilk, S. Taranto, R. Urban, D. Klassen.
United Network for Organ Sharing, Richmond, VA
Background: The HIV Organ Policy Equity (HOPE) Act, enacted on 11/21/13, allows for research on transplants of kidneys (KI) or livers (LI) from HIV+ donors…
2017 American Transplant Congress
Beyond the Bones – The Association Between Vitamin D, Graft Outcomes, Malignancy and Vascular Disease.
A. Seitz,¹ A. Cherukuri,² R. Baker.¹
¹Renal Unit, St James's Hospital, Leeds, West Yorkshire, United Kingdom; ²UPMC, Pittsburgh, PA
Introduction: Vitamin D deficiency in kidney transplant recipients (KTRs) is an emerging theme. The purported associations between Vitamin D deficiency and various metabolic, cardiovascular and…
2017 American Transplant Congress
Forty-Six Consecutive Cases of Pure Live Donor Right or Extended Right Hepatectomy: Single Surgeon Initial 1-Year Experience.
S. Hong, K.-S. Suh, H.-S. Kim, S.-W. Ahn, K. Yoon, D. Oh, H. Kim, N.-J. Yi, K.-W. Lee.
Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea
The pure laparoscopic live donor hepatectomy has been performed in several experienced transplant centers. However, short and long-term surgical outcomes are not yet to be…
2017 American Transplant Congress
The Phenotypic and Functional Characteristics of a Novel CD11b⁺CD11c⁺F4/80⁺ Monocytic Myeloid-Derived Suppressor Cell Subset.
B. Jiang,^1,2 I. Aljabban,¹ C. Yang,¹ D. Ndishabandi,¹ R. White,¹ P. Russell,¹ J. Madsen,¹ R. Colvin,¹ A. Alessandrini.¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston; ²Dept. of Cardiac Surgery, Second Xiangya Hospital, Central South University, Changsha, China
Background: CD11b+Ly6G-Ly6Chigh monocytic myeloid-derived suppressor cells (M-MDSCs) in mice can promote the apoptosis of T cells and induce regulatory T cells. Novel CD11b+CD11c+F4/80+ cells were…
2017 American Transplant Congress
C5b-9 Deposition in Glomerular Capillaries Is Responsible for Poor Allograft Survival in Antibody-Mediated Rejection.
V. Goutaudier,¹ H. Perrochia,¹ M. Marron-Wojewodzki,¹ F. Garo,¹ C. René,¹ N. Pirot,² G. Mourad,¹ M. Le Quintrec.¹
¹University Hospital, Montpellier, France; ²Cancer Research Institute, Montpellier, France
Introduction: C4d (scare of C4 cleavage) deposition in peritubular capillaries (PTC), a marker of complement activation, is associated with antibody-mediated rejection (AMR) in kidney transplantation.…
2017 American Transplant Congress
Type 1 Diabetic Patients Have Better Endothelial Function After Simultaneous Pancreas-Kidney Transplantation Than After Kidney Transplantation with Continued Insulin Therapy.
A. Kolonko,² A. Kowalik,¹ J. Ziaja,¹ D. Kaminska,³ A. Owczarek,⁴ A. Kujawa-Szewieczek,² M. Kusztal,³ J. Badura,¹ D. Bozek-Pajak,¹ A. Zakrzewska,⁵ P. Choreza,⁴ R. Krol,¹ S. Chlopicki,⁵ M. Klinger,³ A. Wiecek,² J. Chudek,⁶ L. Cierpka.¹
¹Medical University of Silesia, Katowice, Poland; ²Medical University of Silesia, Katowice, Poland; ³Wroclaw Medical University, Wroclaw, Poland; ⁴Medical University of Silesia, Sosnowiec, Poland; ⁵Jagiellonian University, Krakow, Poland; ⁶Medical University of Silesia, Katowice, Poland
Objective: The improvement of blood glucose metabolism in type 1 diabetic (T1D) patients after simultaneous pancreas-kidney transplantation (SPK) is anticipated to slow progression of vascular…
2017 American Transplant Congress
Improved Outcome of Kidney Transplants by Donor Recipient Matching Based on Predicted Indirectly Recognizable HLA Epitopes.
O. Staeck,¹ M. Niemann,⁴ F. Halleck,¹ D. Khadzhynov,¹ C. Schönemann,² P. Reinke,¹ E. Spierings,³ K. Budde,¹ N. Lachmann.²
¹Nephrology, Charité Universitaetsmedizin, Berlin, Germany; ²HLA Laboratory, Charité Universitaetsmedizin, Berlin, Germany; ³Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands; ⁴PIRCHE, Berlin, Germany
Introduction: De novo donor-specific HLA antibodies (dnDSA) are recognized as a risk factor for graft loss. Determinants of DSA specificity are generated via the indirect…
2017 American Transplant Congress
Extracellular Mitochondria Cause B7 Costimulation Blockade Resistant Allograft Rejection in Mice.
T. Brennan,¹ L. Lin,¹ M. Song,¹ F. Feng,¹ Q.-J. Li,² A. Kirk,^1,2 H. Xu.¹
¹Surgery, Duke University, Durham, NC; ²Immunology, Duke University, Durham, NC
Introduction: Mitochondria released in the setting of tissue injury and cell death are a source of damage-associated molecular patterns that activate innate immune responses. We…
2017 American Transplant Congress
Intraabdominal Infections (IAI) and Bloodstream Infections in Small Intestinal and Multivisceral Transplants (IMVTX).
A. Spence,¹ S. Fogleman,¹ G. Raffaele,² C. Matsumoto,² P. Kumar,¹ R. Biswas,¹ T. Fishbein,² J. Timpone.¹
¹Division of Infectious Diseases, Medstar Georgetown University Hospital, Washington, DC; ²Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington
BackgroundIMVTX is a treatment option for patients with intestinal failure. IMVTX is often complicated by infection in the post-transplant period with the abdomen and bloodstream…