Am J Transplant, Volume 17, Suppl 3 Archives - Page 3 of 181 - ATC Abstracts

2017 American Transplant Congress
The Phenotypic and Functional Characteristics of a Novel CD11b⁺CD11c⁺F4/80⁺ Monocytic Myeloid-Derived Suppressor Cell Subset.
B. Jiang,^1,2 I. Aljabban,¹ C. Yang,¹ D. Ndishabandi,¹ R. White,¹ P. Russell,¹ J. Madsen,¹ R. Colvin,¹ A. Alessandrini.¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston; ²Dept. of Cardiac Surgery, Second Xiangya Hospital, Central South University, Changsha, China
Background: CD11b+Ly6G-Ly6Chigh monocytic myeloid-derived suppressor cells (M-MDSCs) in mice can promote the apoptosis of T cells and induce regulatory T cells. Novel CD11b+CD11c+F4/80+ cells were…
2017 American Transplant Congress
C5b-9 Deposition in Glomerular Capillaries Is Responsible for Poor Allograft Survival in Antibody-Mediated Rejection.
V. Goutaudier,¹ H. Perrochia,¹ M. Marron-Wojewodzki,¹ F. Garo,¹ C. René,¹ N. Pirot,² G. Mourad,¹ M. Le Quintrec.¹
¹University Hospital, Montpellier, France; ²Cancer Research Institute, Montpellier, France
Introduction: C4d (scare of C4 cleavage) deposition in peritubular capillaries (PTC), a marker of complement activation, is associated with antibody-mediated rejection (AMR) in kidney transplantation.…
2017 American Transplant Congress
Type 1 Diabetic Patients Have Better Endothelial Function After Simultaneous Pancreas-Kidney Transplantation Than After Kidney Transplantation with Continued Insulin Therapy.
A. Kolonko,² A. Kowalik,¹ J. Ziaja,¹ D. Kaminska,³ A. Owczarek,⁴ A. Kujawa-Szewieczek,² M. Kusztal,³ J. Badura,¹ D. Bozek-Pajak,¹ A. Zakrzewska,⁵ P. Choreza,⁴ R. Krol,¹ S. Chlopicki,⁵ M. Klinger,³ A. Wiecek,² J. Chudek,⁶ L. Cierpka.¹
¹Medical University of Silesia, Katowice, Poland; ²Medical University of Silesia, Katowice, Poland; ³Wroclaw Medical University, Wroclaw, Poland; ⁴Medical University of Silesia, Sosnowiec, Poland; ⁵Jagiellonian University, Krakow, Poland; ⁶Medical University of Silesia, Katowice, Poland
Objective: The improvement of blood glucose metabolism in type 1 diabetic (T1D) patients after simultaneous pancreas-kidney transplantation (SPK) is anticipated to slow progression of vascular…
2017 American Transplant Congress
Improved Outcome of Kidney Transplants by Donor Recipient Matching Based on Predicted Indirectly Recognizable HLA Epitopes.
O. Staeck,¹ M. Niemann,⁴ F. Halleck,¹ D. Khadzhynov,¹ C. Schönemann,² P. Reinke,¹ E. Spierings,³ K. Budde,¹ N. Lachmann.²
¹Nephrology, Charité Universitaetsmedizin, Berlin, Germany; ²HLA Laboratory, Charité Universitaetsmedizin, Berlin, Germany; ³Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands; ⁴PIRCHE, Berlin, Germany
Introduction: De novo donor-specific HLA antibodies (dnDSA) are recognized as a risk factor for graft loss. Determinants of DSA specificity are generated via the indirect…
2017 American Transplant Congress
Extracellular Mitochondria Cause B7 Costimulation Blockade Resistant Allograft Rejection in Mice.
T. Brennan,¹ L. Lin,¹ M. Song,¹ F. Feng,¹ Q.-J. Li,² A. Kirk,^1,2 H. Xu.¹
¹Surgery, Duke University, Durham, NC; ²Immunology, Duke University, Durham, NC
Introduction: Mitochondria released in the setting of tissue injury and cell death are a source of damage-associated molecular patterns that activate innate immune responses. We…
2017 American Transplant Congress
Intraabdominal Infections (IAI) and Bloodstream Infections in Small Intestinal and Multivisceral Transplants (IMVTX).
A. Spence,¹ S. Fogleman,¹ G. Raffaele,² C. Matsumoto,² P. Kumar,¹ R. Biswas,¹ T. Fishbein,² J. Timpone.¹
¹Division of Infectious Diseases, Medstar Georgetown University Hospital, Washington, DC; ²Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington
BackgroundIMVTX is a treatment option for patients with intestinal failure. IMVTX is often complicated by infection in the post-transplant period with the abdomen and bloodstream…
2017 American Transplant Congress
Early Results of Immune Profile Emerging Before Detection of De Novo Humoral Alloimmunity in Kidney Transplant Recipients.
J. Zimmerer, B. Ringwald, R. Pelletier, A. El-Hinnawi, A. Rajab, G. Bumgardner.
OSUMC, Columbus
The purpose of this IRB-approved study is to determine if there is a potential role for CD8+ T cell-mediated suppression of donor specific alloantibody (DSA)…
2017 American Transplant Congress
Transplant Center Variability in Disparities for African-American Kidney Transplant Recipients.
D. Taber, M. Gebregziabher, L. Egede, P. Baliga.
MUSC, Charleston, SC
Disparities research has traditionally focused on patient-level variables to ascertain predominant risk factors driving differences in outcomes for African-American (AA) kidney transplant (KTX) recipients. The…
2017 American Transplant Congress
A Combination of Anti-CD40L-Ab, Rapamycin, and Donor Apoptotic Cells Prolongs Allogeneic Pancreatic Islet Survival in Sensitized Mice by Regulating Memory Responses.
A. Dangi,¹ H.-K. Kang,¹ X. Zhang,^2,3 X. Luo.^1,2,3
¹Nephrology and Hypertension, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Northwestern University, Chicago, IL; ³Surgery, Northwestern University, Chicago, IL
Accelerated rejection of allografts has been a clinical challenge in solid organ transplantation particularly in sensitized recipients with donor-specific antibodies (DSA) and memory cell repertoires.…
2017 American Transplant Congress
Impact of a B-Cell Targeting Agent on Antibody Mediated Rejection and Graft' Survival in Liver Transplantation with Preformed DSAs.
A. Del Bello,¹ V. Dubois,² J. Dumortier,³ N. Congy-Jolivet,⁴ N. Kamar.¹
¹Nephrology and Organ Transplant Department, CHU Toulouse, Toulouse, France; ²Department of Immunology, CHU Lyon, Lyon, France; ³Gastroenterology and Liver Transplant Department, CHU Lyon, Lyon, France; ⁴Department of Immunology, CHU Toulouse, Toulouse, France
Introduction The negative impact of preformed anti-HLA donor specific antibodies (DSAs) in liver transplantation is clearly established. However, the potential interest of a B-cell depleting…