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American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Metabolomics Study for Identification of Potential Biomarkers of Long-Term Survival in Kidney Transplantation Recipients.

    C.-D. Kim, H.-Y. Jung, R.-H. Kim, S.-M. Park, J.-H. Park, K.-H. Lee, E.-S. Lee, K.-Y. Kim, J.-Y. Choi, J.-H. Cho, S.-H. Park, Y.-L. Kim.

    Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea

    Background: The development of new strategies to improve long-term survival outcome after kidney transplantation is also becoming important. Although current diagnosis of allograft dysfunction relies…
  • 2017 American Transplant Congress

    Transplant Center Knowledge and Planned Practice of HIV Positive-to-Positive Transplants.

    S. Rasmussen, M. Bowring, A. Shaffer, C. Durand, D. Segev.

    JHU, Baltimore

    Background: The HIV Organ Policy Equity (HOPE) Act (2013) allows deceased and living donor transplantation of HIV-infected (HIV+) organs into HIV+ recipients (HIV-to-HIV) under HRSA…
  • 2017 American Transplant Congress

    Global Kidney Exchange.

    M. Rees,1 T. Dunn,2 S. Rees,3 J. Rogers,4 A. Roth,5 C. Kuhr,6 O. Ekwenna,1 K. Krawiec,7 S. Jain,1 C. Marsh,8 P. Sindhwani,1 M. Zimmerman,9 R. Forbes,10 M. Tan,11 I. Ashlagi,5 R. Correa-Rotter,12 S. Paloyo.13

    1U Toledo, Toledo, OH; 2U Minn, Minneapolis, MN; 3APD, Perrysburg, OH; 4Wake Forrest U, Winston Salem, NC; 5Stanford U, Palo Alto, CA; 6Virginia Mason, Seattle, WA; 7Duke U, Durham, NC; 8Scripps Green Hosp, La Jolla, CA; 9Froedtert Hosp, Milwaukee, WI; 10Vanderbilt U, Nashville, TN; 11Piedmont Hosp, Atlanta, GA; 12INCMNSZ, Mexico City, Mexico; 13St Luke's Hosp, Manila, Philippines

    Introduction: Innovative solutions are required to overcome the organ shortage.Methods: The cost differential between dialysis and transplantation in some countries allows the exchange of kidneys…
  • 2017 American Transplant Congress

    Lower Mean Tacrolimus Troughs Increase Risk of De Novo Donor-Specific Antibodies in the First Year of Kidney Transplant.

    S. Davis, J. Gralla, P. Klem, A. Wiseman, J. Cooper.

    University of Colorado, Aurora, CO

    Development of de novo donor-specific antibodies (dnDSA) is the first step in the evolution of antibody-mediated rejection, which constitutes the leading cause of death-censored graft…
  • 2017 American Transplant Congress

    Multicenter Validation of a Clinicopathologic Risk Score to Predict Hepatocellular Carcinoma Recurrence Following Liver Transplantation: Analysis of 4984 Patients from the US Multicenter HCC Transplant Consortium.

    V. Agopian, On Behalf of the US Multicenter HCC Transplant Consortium.

    UCLA, LA

    Objective: Recurrence of hepatocellular carcinoma (HCC) following liver transplantation (LT) negatively impacts survival. Existing risk prediction models either lack external validation or limit their scope…
  • 2017 American Transplant Congress

    Redefining Pediatric Heart Status 1A and 1B Criteria: Results of Early Policy Evaluation.

    W. Cherikh,1 R. Davies,2 Y. Cheng,1 W. Mahle.3

    1United Network for Organ Sharing, Richmond, VA; 2Alfred I duPont Hosp. for Children, Wilmington, DE; 3Children's Healthcare of Atlanta, Atlanta, GA

    Background. On March 22, 2016, changes to the definitions of pediatric Status 1A and 1 B criteria were implemented in the US. These changes were…
  • 2017 American Transplant Congress

    Incidence of De Novo Donor-Specific Antibodies Following Kidney Transplantation.

    B. Ho,1 H. Bhagat,2 E. Lee,2,3 K. Atiemo,1 A. Daud,1 R. Kang,1 S. Montag,1,4 L. Zhao,1,4 J. Schwartz,2 D. Ladner.1

    1Northwestern University Transplant and Outcomes Research Collaborative (NUTORC), Chicago; 2Astellas Pharma Global Development, Northbrook; 3Now with UCB, Atlanta; 4Dept of Preventive Medicine, Northwestern University, Chicago

    With a range of frequencies reported in several small studies, true incidence of de novo donor-specific human leukocyte antigen (HLA) antibodies (dnDSA) is unknown. As…
  • 2017 American Transplant Congress

    Molecular Profiles of Renal Allograft Biopsies at 12 Months Post Renal Transplant in Patients Exposed to Low Dose CNI and Everolimus vs. Patients Exposed to Full Dose CNI and MMF.

    L. Gallon,1 J. Leventhal,1 D. Maluf,2 V. Sai Bontha,2 A. Shetty,1 O. Traitanon,1 M. Ansari,1 J. Mathew,1 S. Wongpraphairot,1 V. Mas.2

    1Nephrology, Transplant Center, Northwestern University, Chicago; 2University of Virginia, Charlottesville

    CNIs serve as the cornerstone of immunosuppression (IS) after kidney transplant. However chronic CNI nephrotoxicity has been implicated in allograft dysfunction. We hypothesize that lower…
  • 2017 American Transplant Congress

    Genome-Wide Genotyping in 1022 Heart Transplantation Recipients & 758 Donors Reveal Association with Acute Allograft Rejection.

    J. van Setten,1 B. Cole,2 B. Chang,2 N. de Jonge,1 M. Holmes,2 C. Baan,4 O. Manintveld,4 A. Peeters,4 F. Dominguez,5 K. Khush,3 P. Garcia-Pavia,5 M. Huibers,1 R. de Weger,1 J. Moore,2 F. Asselbergs,1 B. Keating.2

    1UMC Utrecht, Utrecht, Netherlands; 2University of Pennsylvania, Philadelphia; 3Stanford University, Stanford, CA; 4Erasmus MC, Rotterdam, Netherlands; 5Puerta de Hierro University Hospital, Madrid, Spain

    Introduction: Acute rejection (AR) in the 1st year post-cardiac transplant remains a significant clinical issue, and predisposes recipients to subsequent chronic allograft vasculopathy. Genetic factors…
  • 2017 American Transplant Congress

    Potential Mechanism Involving Regulatory T Cells in Induction of Tolerance in Mouse Vascularized Composite Allotransplantation Under Combined Costimulation Blockade.

    M. Anggelia,1,2 Y.-Y. Huang,3 W.-Y. Chuang,4 H.-Y. Cheng,1 G. Brandacher,5 F.-C. Wei,1,2 C.-H. Lin.1,2

    1PRS, Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan; 3Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD

    Background: Role of Regulatory T cells in vascularized composite allotransplantation (VCA) remains to be elucidated. In this study, we investigate potential mechanism involved in Tregs…
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