2017 American Transplant Congress
Similar Elevation of Gene Expression Associated with Antibody-Mediated Rejection (ABMR) of Renal Allografts Can Be Detected in Both Plasma Exosomes (pExo) and Biopsies (Bx) by Assessing mRNA Transcript Profiles.
Background: ABMR is a major obstacle for successful transplant in HLA-sensitized patients (Pts). Prediction of ABMR by non-invasive diagnostic tools is desirable. Previously we showed…2017 American Transplant Congress
Belatacept in Chronic Kidney Disease Stabilizes and Improves Renal Function in Pancreas Transplant Recipients: Intermediate Results.
Indiana University Health, Indianapolis
Background: We report our experience in converting Pancreas Transplant recipients from tacrolimus to Belatacept in order to avoid further worsening of kidney function.Results: Eight (7…2017 American Transplant Congress
Non-Renal Factors Predicting Combined Liver-Kidney Transplantation for Non-Dialysis-Requiring Wait-Listed End Stage Liver Disease Patients: 14 Years of US Experience.
University of Florida, Gainesville, FL
OBJECTIVE: We aimed to identify the non-renal factors associated with the higher likelihood of combined liver-kidney transplantation (CLKT) vs. liver transplantation alone (LTA) in end…2017 American Transplant Congress
Lymphotoxin (LT) β Receptor-Mediated Non-Classical NFκB Signaling in Lymphatic Endothelial Eells (LEC) is Required for Homeostatic T Cell Migration.
Background: The selective recruitment of regulatory T cells (Treg) or blockade of memory/effector T cell migration to the graft and draining lymph nodes (dLN) are…2017 American Transplant Congress
Graft-versus-Host Disease in Intestine Transplantation.
Surgery, Indiana University School of Medicine, Indianapolis, IN
PurposeThis study reports the incidence, location, and outcomes of graft-versus-host disease (GVHD) at an active intestine transplant center. Subgroup analysis is employed to assess for…2017 American Transplant Congress
CD4 Depletion Is Necessary and Sufficient for Long-Term Nonhuman Primate Xenotransplant Survival.
Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplant has met limited success. We have previously reported the longest surviving pig-to-nonhuman primate (NHP)…2017 American Transplant Congress
Just Keeps Getting Worse: Racial and Ethnic Disparities in Access to Live Donor Kidney Transplantation in the US Over the Last Twenty Years.
1Johns Hopkins University, Baltimore; 2Northwestern University, Chicago; 3Duke University, Durham
Over the past two decades, there has been increased attention and efforts to reduce racial/ethnic disparities in access to live donor kidney transplantation (LDKT) in…2017 American Transplant Congress
IgM Immunotherapy Restores Immune Homeostasis in Type 1 Diabetes.
Goal: To determine the mechanism(s) by which IgM immunotherapy restores immune homeostasis in Type 1 Diabetes (T1D).Background: IgM immunotherapy prevents the onset and progression of…2017 American Transplant Congress
FOXP3 rs3761548 A/C+A/A Genotype Is a Risk Factor for Steroid Resistant Rejection After Liver Transplantation.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
(Introduction) Previous studies found that preferential accumulation of regulatory T (Treg) cells in the liver allografts during acute cellular rejection (ACR) was associated with less…2017 American Transplant Congress
A Phase-Two, Randomised, Placebo-Controlled Trial: Belimumab in Renal Transplantation Targets Naïve, Activated Memory and Antibody Producing B Cells Whilst Sparing Regulatory B Cells.
This phase 2, double-blind, randomised controlled study (BEL114424) explores the safety and potential efficacy of addition of belimumab to standard of care in renal transplantation…
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