ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Similar Elevation of Gene Expression Associated with Antibody-Mediated Rejection (ABMR) of Renal Allografts Can Be Detected in Both Plasma Exosomes (pExo) and Biopsies (Bx) by Assessing mRNA Transcript Profiles.

    H. Zhang,1 C. Nast,2 J. Doldron,2 M. Cheung,2 J. Mirocha,3 J. Kahwaji,1 A. Vo,1 S. Jordan,1 M. Toyoda.1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles; 2Pathology, Cedars-Sinai Medical Center, Los Angeles; 3Biostatistics Center, Cedars-Sinai Medical Center, Los Angeles

    Background: ABMR is a major obstacle for successful transplant in HLA-sensitized patients (Pts). Prediction of ABMR by non-invasive diagnostic tools is desirable. Previously we showed…
  • 2017 American Transplant Congress

    Belatacept in Chronic Kidney Disease Stabilizes and Improves Renal Function in Pancreas Transplant Recipients: Intermediate Results.

    J. Chen, M. Mujtaba, T. Taber, M. Yaqub, J. Powelson, O. Adebiyi, J. Fridell, A. Sharfuddin.

    Indiana University Health, Indianapolis

    Background: We report our experience in converting Pancreas Transplant recipients from tacrolimus to Belatacept in order to avoid further worsening of kidney function.Results: Eight (7…
  • 2017 American Transplant Congress

    Non-Renal Factors Predicting Combined Liver-Kidney Transplantation for Non-Dialysis-Requiring Wait-Listed End Stage Liver Disease Patients: 14 Years of US Experience.

    A. Santos, M. Casey, K. Alquadan, J. Gregg, K. Womer.

    University of Florida, Gainesville, FL

    OBJECTIVE: We aimed to identify the non-renal factors associated with the higher likelihood of combined liver-kidney transplantation (CLKT) vs. liver transplantation alone (LTA) in end…
  • 2017 American Transplant Congress

    Lymphotoxin (LT) β Receptor-Mediated Non-Classical NFκB Signaling in Lymphatic Endothelial Eells (LEC) is Required for Homeostatic T Cell Migration.

    W. Piao, C. Brinkman, J. Bromberg.

    UMB, Baltimore

    Background: The selective recruitment of regulatory T cells (Treg) or blockade of memory/effector T cell migration to the graft and draining lymph nodes (dLN) are…
  • 2017 American Transplant Congress

    Graft-versus-Host Disease in Intestine Transplantation.

    J. Clouse, C. Kubal, B. Ekser, J. Fridell, R. Mangus.

    Surgery, Indiana University School of Medicine, Indianapolis, IN

    PurposeThis study reports the incidence, location, and outcomes of graft-versus-host disease (GVHD) at an active intestine transplant center. Subgroup analysis is employed to assess for…
  • 2017 American Transplant Congress

    CD4 Depletion Is Necessary and Sufficient for Long-Term Nonhuman Primate Xenotransplant Survival.

    S. Kim, L. Higginbotham, D. Mathews, C. Breeden, A. Stephenson, C. Larsen, M. Ford, J. Tector, A. Adams.

    Emory Transplant Center, Emory University, Atlanta, GA; University of Alabama Birmingham, Birmingham, AL

    Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplant has met limited success. We have previously reported the longest surviving pig-to-nonhuman primate (NHP)…
  • 2017 American Transplant Congress

    Just Keeps Getting Worse: Racial and Ethnic Disparities in Access to Live Donor Kidney Transplantation in the US Over the Last Twenty Years.

    T. Purnell,1 X. Luo,1 L. Kucirka,1 M. Henderson,1 E. Gordon,2 L. Boulware,3 D. Segev.1

    1Johns Hopkins University, Baltimore; 2Northwestern University, Chicago; 3Duke University, Durham

    Over the past two decades, there has been increased attention and efforts to reduce racial/ethnic disparities in access to live donor kidney transplantation (LDKT) in…
  • 2017 American Transplant Congress

    IgM Immunotherapy Restores Immune Homeostasis in Type 1 Diabetes.

    P. Chhabra,1 C. Wilson,2 D. Moore,2 K. Brayman.1

    1Surgery, University of Virginia, Charlottesville, VA; 2Pediatric Endocrinology, Vanderbilt University, Nashville, TN

    Goal: To determine the mechanism(s) by which IgM immunotherapy restores immune homeostasis in Type 1 Diabetes (T1D).Background: IgM immunotherapy prevents the onset and progression of…
  • 2017 American Transplant Congress

    FOXP3 rs3761548 A/C+A/A Genotype Is a Risk Factor for Steroid Resistant Rejection After Liver Transplantation.

    Y. Tanaka, V. Sapana, H. Ohdan.

    Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan

    (Introduction) Previous studies found that preferential accumulation of regulatory T (Treg) cells in the liver allografts during acute cellular rejection (ACR) was associated with less…
  • 2017 American Transplant Congress

    A Phase-Two, Randomised, Placebo-Controlled Trial: Belimumab in Renal Transplantation Targets Naïve, Activated Memory and Antibody Producing B Cells Whilst Sparing Regulatory B Cells.

    G. Banham,1,2 S. Flint,3 N. Torpey,2 P. Lyons,1 D. Shanahan,3 A. Gibson,3 A.-M. O'Sullivan,2 R. Jones,1,2,3 L. Devey,3 A. Richards,3 L. Erwig,3 C. Savage,3 K. Smith,1,2 R. Henderson,3 M. Clatworthy.1,2

    1Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; 2Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom; 3GlaxoSmithKline, Stevenage, United Kingdom

    This phase 2, double-blind, randomised controlled study (BEL114424) explores the safety and potential efficacy of addition of belimumab to standard of care in renal transplantation…
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