Am J Transplant, Volume 17, Suppl 3 Archives - Page 25 of 181 - ATC Abstracts

2017 American Transplant Congress
Neurogenic Orthostatic Hypotension: An Iatrogenic Complication of Successful Pancreas Transplantation?
S. Kuten,¹ E. Simpson,¹ A. Gaber,¹ D. Nguyen,¹ E. Graviss,¹ S. Patel,² R. Knight.¹
¹Houston Methodist Hospital, Houston, TX; ²Veloxis Pharmaceuticals, Cary, NC
Abrupt improvement in glycemic control is known to cause treatment-induced neuoropathies in poorly-controlled diabetes (DM).1 Similarly, neurogenic orthostatic hypotension (OH) is a well-known complication of…
2017 American Transplant Congress
The Association of Donor Vasoactive Drugs with Pancreas Transplant Graft Survival.
I. Shapey,¹ P. Yianoullou,² A. Summers,² T. Augustine,² M. Rutter,¹ D. van Dellen.²
¹Division of Diabetes, Endocrinology and Gastroenterology, University of Manchester, Manchester, United Kingdom; ²Department of Renal and Pancreas Transplantation, Central Manchester University Hospitals, Manchester, United Kingdom
Introduction: Vasoactive drugs (VaD) are commonly used to correct abnormal haemodynamics of organ donors in Intensive Care Units (ICU). VaDs can differentially affect insulin secretion…
2017 American Transplant Congress
eHealth Literacy and Patient Portal Utilization Among Transplant Recipients.
K. Smith, A. Ruiz, J. Wedd, S. Pastan, R. Parker, R. Patzer.
Emory Transplant Center, Atlanta, GA
Background: Healthcare systems are required to engage patients with web-based patient portals. eHealth literacy is a distinct type of health literacy needed to properly understand…
2017 American Transplant Congress
Lymphoproliferative Disorders After Renal Transplantation Along Two Decades: A Large Longitudinal Study.
A. Franco,¹ D. Hernandez,² N. Maruri,³ A. Alonso,⁴ M. Crespo,⁵ A. Mazuecos,⁶ C. Diaz-Corte,⁷ M. Gentil.⁸
¹Nephrology, Hospital General, Alicante, Spain; ²Nephrology, Hospital Carlos Haya, Málaga, Spain; ³Nephrology, Hospital Cruces, Bilbao, Spain; ⁴Nephrology, Hospital Universitario, A Coruña, Spain; ⁵Nephrology, Hospital del Mar, Barcelona, Spain; ⁶Nephrology, Hospital Puerta del Mar, Cadiz, Spain; ⁷Nephrology, Hospital General, Oviedo, Spain; ⁸Nephrology, Hospital Virgen del Rocío, Sevilla, Spain
In a longuitudinal study,we evaluated the cumulative incidence of Posttransplant limphoproliferative disorders(PTLD),its relationship with Epstein Barr Virus (EBV),classical risk factors and outcome in 21546 single…
2017 American Transplant Congress
A Composite Score Associated with Spontaneous Operational Tolerance in Kidney Transplant Recipients.
R. Danger,¹ M. Chesneau,¹ C. Paul,¹ P. Guérif,¹ M. Durand,¹ K. Newell,² S. Kanaparthi,³ L. Turka,⁴ J.-P. Soulillou,¹ R. Houlgatte,⁵ M. Giral,^1,6 G. Ramstein,⁷ S. Brouard.^1,6
¹Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; ²Department of Surgery, Emory University, Atlanta, GA; ³Immune Tolerance Network, Bethesda, MD; ⁴Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁵INSERM UMR 954,CHU de Nancy, DRCI, Nancy, France; ⁶CIC Biotherapy, CHU Nantes, Nantes, France; ⁷LINA DUKe, UMR 6241, Université de Nantes, Ecole des Mines de Nantes & CNRS, Nantes, France
New challenges in renal transplantation include using biological information to devise a useful clinical test for discerning high- and low-risk patients for individual therapy and…
2017 American Transplant Congress
Dendritic Cells That Highly Express SOCS1 Induce T-Cell Hypo-Responsiveness and Prolong Islet Allograft Survival.
R. Deng, X. Lu, M. Chen, Z. Xue, X. Zhang, J. Xu, L. Wu, Y. Ma.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
The capability of dendritic cells (DCs) to induce an immune response or immune tolerance is dependent on their status. Suppressor of cytokine signaling 1 (SOCS1)…
2017 American Transplant Congress
Impact of Culture Expansion and Inflammatory Cytokine Challenge on DNA Methylation Profiles in MSC.
S. de Witte,¹ F. Peters,¹ A. Merino,¹ S. Korevaar,¹ S. Elliman,³ P. Newsome,² J. Meurs,¹ K. Boer,¹ C. Baan,¹ M. Hoogduijn.¹
¹Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands; ²Orbsen Therapeutics Ltd., Galway, Ireland; ³Department of NIHR Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom
Mesenchymal stromal cells (MSC) are studied as possible immunotherapy after solid organ transplantation. However, to obtain sufficient numbers, cells need to be expanded in culture.…
2017 American Transplant Congress
Transcriptome Analysis of CD4-Lymphocyte Specifically Deleted of IKKbeta or NEMO in an Experimental Model of Rapid Progressive Glomerulonephritis (RPGN).
F. Thaiss,¹ J. Huang,² M. Chen,¹ H. Paust,¹ G. Zahner,¹ M. Alawi,² R. Geffers,³ L. Guo.¹
¹Nephrology, Univ. Hospital UKE, Hamburg, Germany; ²Bioinformatics, Univ. Hospital UKE, Hamburg, Germany; ³Genomics, Helmholtz Center Infection, Braunschweig, Germany
RPGN is T-cell mediated and can recur after kidney transplantation. T-cell receptor stimulation leads to intracellular signaling events ultimately causing activation of transcription factors such…
2017 American Transplant Congress
Imaging Cell Biology in Transplantation.
T. Ueno,¹ M. McGrath,¹ M. Yeung,¹ K. Jung,² Y. Kihara,³ O. Konno,³ Y. Nakamura,³ H. Iwamoto,³ S. Yun,² A. Chandraker.¹
¹Transplantation Research Center, Brighma and Women's Hospital, Harvard Medical School, Boston, MA; ²Department of Dermatology, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Transplantation Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan
Background: Following transplantation, a set of coordinated events occurs within the recipient immune system. Immature dendritic cells (DCs) migrate to sites of inflammation, become activated…
2017 American Transplant Congress
Direct Comparison of Hypothermic and Normothermic Organ Preservation in a Porcine Ex-Vivo Kidney Model.
N. Vallant,^1,2 B. Sandhu,¹ N. Wolfhagen,¹ C. Pusey,¹ V. Papalois.¹
¹Renal and Transplant Department, Imperial College, London, United Kingdom; ²Department of Visceral-, Transplant- and Thoracic Surgery, Medical University, Innsbruck, Austria
Background: Hypothermic machine perfusion is a well established method for deceased donor organ preservation as well as pre-transplant assessment and preconditioning. Recent translational and clinical…