Am J Transplant, Volume 17, Suppl 3 Archives - Page 24 of 181 - ATC Abstracts

2017 American Transplant Congress
De Novo Low-Dose Sirolimus versus Mycophenolate Mofetil in Combination with Extended-Release Tacrolimus in Kidney Transplant Recipients.
J. Lee,¹ K. Huh,¹ J. Ha,² C.-K. Oh,³ M. Ju,⁴ C.-D. Kim,⁵ H. Cho,⁶ C. Jung,⁷ B. Lim,⁸ Y. Kim.¹
¹Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea; ²Surgery, Seoul National University Hospital, Seoul, Republic of Korea; ³Surgery, Ajou University Hospital, Suwon, Republic of Korea; ⁴Surgery, Gangnam Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea; ⁵Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea; ⁶Surgery, Ulsan University Hospital, Ulsan, Republic of Korea; ⁷Surgery, Korea University Anam Hospital, Seoul, Republic of Korea; ⁸Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea
Previous studies reported that tacrolimus (TAC) with high-dose sirolimus (SRL) was associated with worse outcomes in kidney transplantation, compared to TAC with mycophenolate mofetil (MMF.).…
2017 American Transplant Congress
A Universal Strategy to Characterize Allograft Infiltrating Cells by Bioinformatics Deconvolution of Next Generation Sequencing Data.
G. Thareja,¹ H. Yang,² S. Hayat,¹ C. Li,² F. Mueller,² C. Snopkowski,² L. Perry,² M. Magruder,² J. Lee,² D. Dadhania,² K. Suhre,¹ M. Suthanthiran,² T. Muthukumar.²
¹Weill Cornell Medicine-Qatar, Doha, Qatar; ²Weill Cornell Medicine, New York
RNA sequencing characterizes mRNA transcriptome at an unprecedented level of precision. Because organ transplantation is a unique situation of mRNAs encoded by two (donor and…
2017 American Transplant Congress
Even with National Sharing, the Prospects of a 100% Sensitized Patient Receiving a Transplant Vary Dramatically Depending on the Precise CPRA Value.
D. Stewart,¹ A. Kucheryavaya,¹ D. Tyan,² H. Gebel,³ R. Bray,³ N. Turgeon.³
¹UNOS, Richmond, VA; ²Stanford Univ, Palo Alto, CA; ³Emory Univ Hosp, Atlanta, GA
Background: In the Kidney Allocation System (KAS), CPRA of 99% & 100% candidates receive regional and national priority. This broader sharing, along with adoption of…
2017 American Transplant Congress
Geographic Disparity in Kidney Transplantation After KAS.
S. Zhou,¹ A. Massie,¹ X. Luo,¹ E. Chow,¹ S. Bae,¹ S. Gentry,² S. Gustafson,³ A. Wey,³ B. Thompson,³ N. Salkowski,³ J. Snyder,³ D. Segev.¹
¹JHU, Baltimore; ²USNA, Annapolis; ³CDRG, Minneapolis
The Kidney Allocation System (KAS), implemented in 12/2014, increased regional and national sharing of kidneys. Ideally, broader sharing would also reduce some of the stark…
2017 American Transplant Congress
The Innate Immune-System May Play an Enhanced Role in Acute Cellular Rejection in Patients on Belatacept-Based Immunosuppression.
D. Dobi,¹ Q. Tang,² S. Chandran,³ F. Vincenti,³ Z. Laszik.¹
¹Department of Pathology, University of California, San Francisco, San Francisco, CA; ²Department of Surgery, Division of Transplant Surgery, University of California, San Francisco, San Francisco, CA; ³Department of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, CA
Purpose. The incidence of acute cellular rejection (ACR) in kidney transplant patients on Belatacept (Bela-ACR) is higher than in those with CNI-based regimens (CNI-ACR). However,…
2017 American Transplant Congress
Antibody Mapping by Protein Microarray Revealed a Unique Repertoire in Lung Transplant Recipients That Developed Chronic Lung Allograft Dysfunction.
D. Nayak,¹ K. Garcia,² P. Pirrotte,² R. Hachem,³ R. Bremner,¹ M. Smith,¹ T. Mohanakumar.¹
¹Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ; ²Translational Genomics Research Institute, Phoenix, AZ; ³Washington University, St. Louis, MO
Background: Development of chronic lung allograft dysfunction (CLAD) limits long-term success from lung transplantation (LTx). Elicitation of de novo antibody (Ab) to mismatched donor HLA…
2017 American Transplant Congress
Multiple Dosing of Anti-C1s Antibody TNT009 – Effect on HLA Antibody-Triggered Complement Activation in Healthy Volunteers and Kidney Transplant Recipients with Antibody-Mediated Rejection.
J. Muhlbacher,¹ B. Jilma,² M. Wahrmann,³ F. Eskandary,³ J. Gilbert,⁴ S. Panicker,⁴ G. Böhmig.³
¹Department of Surgery, Medical University Vienna, Vienna, Austria; ²Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria; ³Department of Medicine III, Medical University Vienna, Vienna, Austria; ⁴True North Therapeutics, Inc., San Francisco, CA
Study purpose. Complement inhibition may be an attractive strategy to prevent antibody-mediated allograft injury. One promising therapeutic target may be the enzymatic activity of key…
2017 American Transplant Congress
2B4-Mediated Inhibition of Proliferation and Glycolytic Function Attenuates T Cell Alloreactivity.
S. Laurie, D. Liu, M. Cortes, M. Wagener, M. Ford.
Emory Transplant Center, Atlanta, GA
Current thinking holds that costimulation-blockade resistant graft rejection may be mediated by CD28null T cells. To further investigate this possibility, we performed a retrospective immunophenotypic…
2017 American Transplant Congress
Applicability and Safety of a Regulatory T Cell Therapy in Adult Liver Transplantation: The “ThRIL” Phase I First-in-Human Trial.
G. Whitehouse, N. Safinia, S. Thirkell, L. Fry, N. Grageda, M. Martinez-Llordella, R. Lechler, N. Heaton, G. Lombardi, A. Sanchez-Fueyo.
MRC Centre for Transplantation, King's College London, London, United Kingdom
Aim“ThRIL” is a multiple site, open-label, uncontrolled, phase I clinical trial assessing the safety and applicability of a CD4+CD25+FOXP3+ regulatory T cell (Treg) immunotherapy in…
2017 American Transplant Congress
Kidney Injury Molecule-1 Mitigates Tissue Damage from Transplant Renal Ischemia Reperfusion Injury.
J. Lee,^1,2 X. Zhang,² A. Haig,³ D. Lian,² P. Anderson,² R. Navaratnam,² L. Gunaratnam.^1,2
¹Department of Microbiology and Immunology, Western University, London, ON, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ³Department of Pathology, Western University, London, ON, Canada
Ischemia reperfusion injury (IRI) at the time of organ harvesting is unavoidable, may cause delayed renal graft function, and is associated with premature graft loss.…