ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Acute Cellular Rejection Is Associated with Increased Risk of Early and Late Graft Failure.

    A. Massie, J. Garonzik-Wang, D. Segev.

    JHU, Baltimore

    The association between acute cellular rejection and subsequent early and late graft loss has not been well-quantified.METHODS: Using SRTR data and Cox regression, we studied…
  • 2017 American Transplant Congress

    Signal Inhibitory Regulatory Protein-α Regulates Pathologic Reactive Oxygen Species in Acute Kidney Injury.

    N. Rogers,1,2,3 D. Meijles,3 P. Pagano,3 J. Isenberg.3

    1Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, NSW, Australia; 2Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA; 3Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

    Background: Ischemia reperfusion injury (IRI) is mediated by a complex cascade of pro-inflammatory and oxidative processes. We have reported that signal regulatory inhibitory protein (SIRP)-α…
  • 2017 American Transplant Congress

    Emerging Safety and Tolerability of Obinutuzumab, a Type 2 Anti-CD20 Monoclonal Antibody for the Desensitization of Renal Transplant Candidates.

    R. Redfield,1 S. Jordan,2 T. Schindler,3 H. Tran,4 C. Looney,4 C. Green,4 A. Morimoto,4 R. Rajwanshi,4 M. Cascino,4 P. Brunetta,4 D. Borie.4

    1University of Wisconsin, Madison; 2Cedars-Sinai Medical Center, Los Angeles; 3F. Hoffmann-La Roche AG, Basel, Switzerland; 4Genentech, Inc., South San Francisco

    Background: Rituximab has limited efficacy for desensitizing allosensitized patients (pts) with end-stage renal disease (ESRD) and enabling kidney transplantation (KTx), however, tissue B-cell depletion is…
  • 2017 American Transplant Congress

    Elevated Circulating AT1R Levels Indicate Heightened Risk for Antibody Mediated Rejection and Graft Failure.

    P. Kimball, G. Gupta, F. McDougan.

    Transplant Surgery, VCUHealth Systems, Richmond, VA

    Background.Antibody(Ab) against the angiotensin II receptor(AT1R) can cause antibody mediated rejection(AMR) and graft failure after transplantation. We evaluated whether circulating AT1R is a potential marker…
  • 2017 American Transplant Congress

    Microarray Analysis of Rejection in Formalin-Fixed Paraffin-Embedded Biopsies: Similarities and Disparities with Conventionally Stabilized Biopsies.

    K. Famulski, J. Revee, P. Halloran.

    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada

    Despite potential for performing molecular diagnostics on formalin-fixed paraffin embedded (FFPE) biopsies, there has been no systematic comparison of microarray gene expression data obtained from…
  • 2017 American Transplant Congress

    iNKT Cell Activation Plus Veto Cell Transfer Yields Complete Chimerism in a Murine Sub-Lethal Bone Marrow Transplant Model.

    R. Ishii,1 T. Hirai,1 Y. Ishii,2 M. Okumi,1 K. Tanabe.1

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Cluster for Industry Partnerships (CIP), RIKEN, Yokohama, Japan

    Transplant tolerance induction makes it possible to preserve functional grafts for a lifetime without immunosuppressants. We have previously established a novel method for mixed chimera…
  • 2017 American Transplant Congress

    Presence of Complement Activating Donor Specific Antibodies Is Associated with Poor Renal Allograft Survival: Two Centre Retrospective Study.

    A. Babu,1,4,5 O. Shaw,2 L. Howe,2 N. Kessaris,3 A. Dorling,3 N. Mamode,3 R. Vaughan,2 N. Krishnan,5 R. Higgins,5 D. MItchell,1 D. Briggs,4 S. Daga.1,5,6

    1Warwick Medical School, University of Warwick, Coventry, United Kingdom; 2Clinical Transplantation Laboratories, Guy's Hospital, Viapath, London, United Kingdom; 3Nephrology and Transplantation, Guy's Hospital, London, United Kingdom; 4Histocompatibility and Immunogenetics, NHS Blood and Transfusion, Birmingham, United Kingdom; 5Nephrology and Transplantation, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom; 6Nephrology and Transplantation, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Introduction: Complement fixing donor specific antibodies (DSA) as detected by presence of C3d at the time of rejection is associated with poor graft outcome;no studies…
  • 2017 American Transplant Congress

    The Glasgow Prognostic Score and Its Variants Predict Mortality in Living Donor but Not in Deceased Donor Liver Transplantation for Hepatocellular Carcinoma: A Double-Center Validation Study.

    A. Kaltenborn,1 J. Gwiasda,1 N. Heits,2 F. Braun,2 H. Schrem.1

    1Core Facility Quality Management Transplantation, Hannover Medical School, Hannover, Germany; 2Department of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Medical Center Schleswig-Holstein, Kiel, Germany

    The notion that inflammation parameters such as CRP and albumin might have an influence on outcome in malignant disease is gaining interest. Serum CRP- and…
  • 2017 American Transplant Congress

    Favorable Long-Term Prognosis of Hepatitis B Surface Antigen Positive Intrahepatic Cholangiocarcinoma for Both Hepatic Resection and Incidental Liver Transplantation via Inhibiting Cancer-Associated Lymphangiogenesis.

    J. Gu, S. Jeong, M. Sha, J. Zhang, Q. Xia.

    Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    Background: In recent years, a few publications indicated that hepatitis B virus (HBV) infection is associated with the prognosis of patients with ICC after resection.…
  • 2017 American Transplant Congress

    Accepting a High-KDPI Kidney versus Waiting for Another Offer Can Improve Chances of a Functioning Graft.

    A. Wey,1 N. Salkowski,1 W. Kremers,2 A. Israni,1 B. Kasiske,1 J. Snyder.1

    1Scientific Registry of Transplant Recipients, Minneapolis, MN; 2Mayo Clinic, Rochester, MN

    Less than 50% of waitlisted candidates undergo a first deceased donor transplant within 5 years. Yet approximately 20% of recovered kidneys and >50% of kidneys…
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