Am J Transplant, Volume 17, Suppl 3 Archives - Page 2 of 181 - ATC Abstracts

2017 American Transplant Congress
Post-Donation GFR Changes in Living Kidney Donors.
E. Poggio,¹ S. Arrigain,² J. Augustine,¹ S. Flechner,³ J. Schold.²
¹Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH; ²Qualitative Health Sciences, Cleveland Clinic, Cleveland, OH; ³Urology, Cleveland Clinic, Cleveland, OH
Living kidney donor transplantation is the preferred treatment for ESRD because it confers excellent outcomes for recipients and poses reasonable risks to donors. Post-donation glomerular…
2017 American Transplant Congress
TIE'ing Statins to Microvascular Stability and Endothelial Cell Immunogenicity.
C. Ghosh,¹ A. Mak,¹ M. McGourty,¹ S. Parikh,² X. Chen,² S. Goldberg,¹ J. Wedel,¹ D. Briscoe.¹
¹Transplant Research Program, Boston Children's Hospital, Boston, MA; ²Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA
Graft microvascular endothelial cells (EC) represent a critical interface between the recipient and the donor. Stable/quiescent EC support immunoregulation in part via the expression of…
2017 American Transplant Congress
Saftey & Long Term Outcomes of Tocilizumab (Anti-IL6R, TCZ) Therapy in Treatment of Chronic Antibody Mediated Rejection (CABMR) & Transplant Glomerulopathy (TG) in Highly-HLA Sensitized (HS) Patients (PTs).
J. Choi,¹ O. Aubert,² A. Vo,¹ A. Loupy,² M. Haas,³ S. Louie,¹ A. Kang,¹ A. Peng,¹ R. Najjar,¹ E. Huang,¹ M. Toyota,⁵ X. Zhang,⁴ S. Jordan.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Paris Transplant Group, University Paris Descartes, Paris, France; ³Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ⁴Department of HLA Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ⁵Transplant Immunology Lab, Cedars-Sinai Medical Center, Los Angeles, CA
Introduction: DSAs in HS pts lead to poor allograft survival & return to a dialysis. Treatment options for CABMR and TG are limited. IL-6 appears…
2017 American Transplant Congress
Generation of Natural Antibodies Post Transplant and Association with Kidney Allograft Loss.
S. See,¹ A. Loupy,² O. Aubert,² Y. Veras,¹ X. Lebreton,² B. Gao,³ C. Legendre,² D. Anglicheau,² E. Zorn.¹
¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY; ²Department of Kidney Transplantation, Hopital Necker, Université Paris, René Descartes and APHP, Paris, France; ³The First Hospital of Jilin University, Changchun, China
The development of donor specific antibodies (DSA) reacting to mismatched donor class I and class II HLA is a prominent risk factor for kidney graft…
2017 American Transplant Congress
Cumulative Deficits Frailty Index for Transplant Candidates Predicts Candidacy for Solid Organ Transplantation.
R. Varughese,^1,2 O. Theou,³ X. Huang,¹ O. Famure,¹ Y. Li,¹ N. Chowdhury,¹ E. Renner,^1,2 J. Kim,^1,2 J. MacIver,^1,5 S. Mathur,⁴ K. Rockwood,³ L. Singer.^1,2
¹Toronto Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Department of Medicine, University of Toronto, Toronto, ON, Canada; ³Department of Medicine, Dalhousie University, Halifax, NS, Canada; ⁴Department of Physical Therapy, University of Toronto, Toronto, ON, Canada; ⁵Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada
Introduction: Frailty is a clinical state associated with decreased function and increased vulnerability to physiologic stressors, leading to adverse medical outcomes. The cumulative deficits model…
2017 American Transplant Congress
HOPE Act – The First Year.
A. Wilk, S. Taranto, R. Urban, D. Klassen.
United Network for Organ Sharing, Richmond, VA
Background: The HIV Organ Policy Equity (HOPE) Act, enacted on 11/21/13, allows for research on transplants of kidneys (KI) or livers (LI) from HIV+ donors…
2017 American Transplant Congress
Beyond the Bones – The Association Between Vitamin D, Graft Outcomes, Malignancy and Vascular Disease.
A. Seitz,¹ A. Cherukuri,² R. Baker.¹
¹Renal Unit, St James's Hospital, Leeds, West Yorkshire, United Kingdom; ²UPMC, Pittsburgh, PA
Introduction: Vitamin D deficiency in kidney transplant recipients (KTRs) is an emerging theme. The purported associations between Vitamin D deficiency and various metabolic, cardiovascular and…
2017 American Transplant Congress
Forty-Six Consecutive Cases of Pure Live Donor Right or Extended Right Hepatectomy: Single Surgeon Initial 1-Year Experience.
S. Hong, K.-S. Suh, H.-S. Kim, S.-W. Ahn, K. Yoon, D. Oh, H. Kim, N.-J. Yi, K.-W. Lee.
Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea
The pure laparoscopic live donor hepatectomy has been performed in several experienced transplant centers. However, short and long-term surgical outcomes are not yet to be…
2017 American Transplant Congress
The Phenotypic and Functional Characteristics of a Novel CD11b⁺CD11c⁺F4/80⁺ Monocytic Myeloid-Derived Suppressor Cell Subset.
B. Jiang,^1,2 I. Aljabban,¹ C. Yang,¹ D. Ndishabandi,¹ R. White,¹ P. Russell,¹ J. Madsen,¹ R. Colvin,¹ A. Alessandrini.¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston; ²Dept. of Cardiac Surgery, Second Xiangya Hospital, Central South University, Changsha, China
Background: CD11b+Ly6G-Ly6Chigh monocytic myeloid-derived suppressor cells (M-MDSCs) in mice can promote the apoptosis of T cells and induce regulatory T cells. Novel CD11b+CD11c+F4/80+ cells were…
2017 American Transplant Congress
C5b-9 Deposition in Glomerular Capillaries Is Responsible for Poor Allograft Survival in Antibody-Mediated Rejection.
V. Goutaudier,¹ H. Perrochia,¹ M. Marron-Wojewodzki,¹ F. Garo,¹ C. René,¹ N. Pirot,² G. Mourad,¹ M. Le Quintrec.¹
¹University Hospital, Montpellier, France; ²Cancer Research Institute, Montpellier, France
Introduction: C4d (scare of C4 cleavage) deposition in peritubular capillaries (PTC), a marker of complement activation, is associated with antibody-mediated rejection (AMR) in kidney transplantation.…