2017 American Transplant Congress
Cardiovascular Events Are a Substantial and Increasing Cause of Graft Loss in Liver Transplant Recipients.
Pharmacy, Transplant, MUSC, Charleston, SC
Purpose: The overall 1- and 3- year graft survival rates following liver transplant are 89.1% and 79.9%, respectively. While these numbers have vastly improved, they…2017 American Transplant Congress
Is “Death with a Functioning Graft (DWF)” Really Death with Function? Data from the Long-Term Deterioration of Kidney Allograft Function (DeKAF) Study.
To understand causes of kidney transplant (KT) failure, outcomes are often segregated into death-censored graft failure (DCGF, a proxy for immunologic injury) and DWF. To…2017 American Transplant Congress
The Impact of the New Kidney Allocation System on Length of Dialysis Prior to Transplantation.
1Emory University, Atlanta; 2Columbia University, New York
Introduction: The Kidney Allocation System (KAS) changed the starting point for calculating waiting time for patients on the kidney transplant (KTx) waitlist from the time…2017 American Transplant Congress
The Natural History of Kidney Rejection: How Do Molecular Disease States Change Over Time in Patients with Repeat Indication Biopsies?
University of Alberta, Edmonton, AB, Canada
Molecular phenotypes are highly reproducible, but how do they evolve over time? In an unsupervised microarray analysis, 1208 kidney transplant biopsies were assigned to one…2017 American Transplant Congress
The Degree of NK Cell Activation Determines the Ability of Donor-Specific Antibodies to Mediate Acute vs. Chronic Rejection of Kidney Allografts.
While the incidence of antibody-mediated kidney graft rejection has increased, the key cellular and molecular participants underlying this graft injury remain unclear. We have previously…2017 American Transplant Congress
Intensive Care Unit Enhanced Recovery Pathway for Liver Transplant Recipients: A Prospective, Observational Study.
Vanderbilt University Medical Center, Nashville
Purpose: Surgical clinical pathways have been shown to be effective for enhanced recovery and cost reductions, yet have not be tested in liver transplant (LT)…2017 American Transplant Congress
Quantitative Analysis of 10-Year Surveillance Renal Allograft Biopsies.
Introduction. Assessing late histologic changes in renal allografts is important to investigating etiology and devising treatment. Compared to the usual semi-quantitative reading by a renal…2017 American Transplant Congress
KDPI and Small (<20 kg) Pediatric Kidney Donors.
1Seattle Children's Hospital, Seattle; 2Scientific Registry of Transplant Recipients, Minneapolis
Use of small (≤20 kg) donor kidneys in pediatric candidates has declined under the new kidney allocation system (KAS), from 5.0% of pediatric kidney-alone transplants…2017 American Transplant Congress
CCR7+CD8+ T Cell Suppresses Effector T Cell Related Allo-Immune Responses in Kidney Transplant Recipients.
Internal Medicine, Seoul St. Mary's Hospital, Seoul, Korea
Background; Previously reports showed that CCR7+CD8+ T cells have suppressive effect on various pathogenic immune cells. The aim of this study is to investigate the…2017 American Transplant Congress
Dual Costimulatory Blockades Failed to Achieve Transplant Tolerance Despite Induction of Mixed Chimerism in NHPs.
Background: Our previous studies showed that substantial deletion of CD8+ memory T cells (TMEM) was necessary to induce mixed chimerism (MC) and allograft tolerance when…
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