Am J Transplant, Volume 17, Suppl 3 Archives - Page 168 of 181 - ATC Abstracts

2017 American Transplant Congress
The Benefits of Pancreas After Kidney (PAK) Transplantation.
M. Curry,¹ J. Odorico,² J. Fridell.³
¹Research, UNOs, Richmond, VA; ²Department of Surgery, University of Wisconsin, Madison, WI; ³Department of Surgery, Indiana University, Indianpolis, IN
Background: PAK transplantation has been perceived as inferior to Simultaneous Pancreas and Kidney (SPK) transplantation with respect to patient and pancreas (PA) allograft survival. However,…
2017 American Transplant Congress
Eight Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients.
J. Leventhal,¹ J. Galvin,¹ J. Mathew,¹ L. Gallon,¹ D. Stare,¹ A. Sweeney,¹ J. Miller,¹ M. Abecassis,¹ S. Ildstad.²
¹Northwestern University, Chicago; ²U of Louisville, Louisville
36 subjects have been transplanted in a phase 2 protocol (IDE 13947) to induce tolerance in recipients of living donor renal allografts (KTx). The protocol…
2017 American Transplant Congress
Designing a Novel Selective Immunoproteasome Inhibitor Reveals a Critical Role of the IP and STAT5 Pathway in Regulating T Cell Exhaustion and Promoting Long Term Heart Allograft Acceptance.
S. Routray, E. Karreci, M. Uehara, J. Assaker, A. Mihali, S. Eskandari, L. Riella, R. Abdi, Y. Kawano, C. Nathan, G. Lin, J. Azzi.
Transplant Research Center, Harvard Medical School, Boston, MA; Microbiology and Immunology, Weill Cornell Medicine, New York, NY
Constitutive proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. Immunoproteasomes (IP or i-20S) are primarily expressed in immune…
2017 American Transplant Congress
Influenza Viral Dynamics in a Large Cohort of Transplant Patients with Natural Influenza Infection.
V. Ferreira,¹ A. Humar,¹ E. Cordero,² E. Blumberg,³ A. Limaye,⁸ F. Silveira,⁵ L. Danziger-Isakov,⁶ M. Levi,⁷ J. Kalpoe,⁴ J. Englund,⁹ M. Multicenter Influenza Group, D. Kumar.¹
¹UHN, Toronto, Canada; ²REIPI, Seville, Spain; ³UPenn, Philadelphia; ⁴LUMC, Leiden, Netherlands; ⁵UPMC, Pittsburgh; ⁶CCHMC, Cincinnati; ⁷UCD, Denver; ⁸UW, Seattle; ⁹SCH, Seattle
Background:Influenza infection significantly impacts transplant patients. Despite this, there are limited data on how virological characteristics, including influenza viral load (VL), impact the outcome of…
2017 American Transplant Congress
Impact of Cognitive Impairment on Kidney Transplantation Listing Between Sexes.
C. Haugen,¹ H. Ying,² J. Garonzik Wang,¹ M. McAdams-DeMarco,² D. Segev.^1,2
¹Surgery, JHU, Baltimore; ²Epidemiology, JHU, Baltimore
Cognitive impairment (CI) is common in end-stage renal disease (ESRD) patients and is associated with greater mortality. Despite this, cognitive function is not routinely measured…
2017 American Transplant Congress
Long-Term Consequences of Post-Donation Preeclampsia.
H. Ibrahim,¹ D. Berglund,¹ S. Jackson,² A. Matas.¹
¹UofMN, Mpls; ²M Health, Mpls
Preeclampsia (PE) has been linked to future development of ESRD in the general population. PE is more likely to occur in post-kidney donation pregnancies. Whether…
2017 American Transplant Congress
Ischemia-Reperfusion Injury-Induced Innate Immune Signaling in Human Orthotopic Liver Transplantation.
R. Sosa,¹ A. Zarrinpar,² M. Rossetti,¹ C. Lassman,¹ B. Naini,¹ N. Datta,² R. Busuttil,² D. Gjertson,¹ J. Kupiec-Weglinski,^1,2 E. Reed.¹
¹Pathology and Laboratory Medicine, University of California, Los Angeles, CA; ²Surgery, University of California, Los Angeles, CA
Background: Ischemia-reperfusion injury (IRI) is a major risk factor in the development of acute and chronic graft rejection in orthotopic liver transplantation (OLT); however, no…
2017 American Transplant Congress
Complement Activating Anti-HLA Antibodies: Identification of Specific Histo-Mmolecular Phenotype of Rejection for Complement-Targeting Therapy.
C. Lefaucheur,¹ B. Sis,² D. Viglietti,¹ L. Hidalgo,² O. Aubert,¹ D. Glotz,¹ C. Legendre,¹ A. Zeevi,³ P. Halloran,² A. Loupy.¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France; ²University of Alberta, Edmonton, Canada; ³University of Pittsburgh Medical Center, Pittsburgh
Addressing the heterogeneity of antibody-mediated allograft rejection by identifying phenotypes based on pathophysiology is critical for improving outcomes in transplantation. We investigated whether complement-binding anti-HLA…
2017 American Transplant Congress
Donor-Specific B Cell Responses: Predicting the Future of Kidney Transplants.
M. Cascalho,¹ E. Farkash,² L. Adam,¹ M. Samaniego,³ J. Platt.
¹Surgery, University of Michigan, Ann Arbor; ²Pathology, University of Michigan, Ann Arbor; ³Internal Medicine, University of Michigan, Ann Arbor
Allogeneic cell and tissue transplants nearly always evoke B cell responses ascertainable by detecting donor-specific antibodies (DSA) in the circulation of the recipient. DSA are…
2017 American Transplant Congress
Provision of Highly Specialized Aftercare by the Transplant Center Strongly Improves Patient and Allograft Survival in Long-Term Follow-Up After Kidney Transplantation.
T. Schachtner,^1,2,3 P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany; ³Berlin Institute of Health BIH, Berlin, Germany
Despite rapid medical advancements in the field of transplantation, mean kidney allograft survival remained at a standstill. If and to what extent a highly specialized…