Am J Transplant, Volume 17, Suppl 3 Archives - Page 156 of 181 - ATC Abstracts

2017 American Transplant Congress
Aquaporin 4 Blockade Alters T Cell Anatomical Distribution and Prolongs Cardiac Allograft Survival in Sensitized Recipients.
M. Nicosia,¹ R. Fan,¹ G. Farr,² M. Pelletier,² P. McGuirk,² K. Ayasoufi,¹ A. Valujskikh.¹
¹Immunology, Cleveland Clinic, Cleveland; ²Aeromics, Inc., Cleveland
Aquaporins are water channels present on mammalian cells. We previously reported that aquaporin 4 (AQP4) blockade with small molecule inhibitor AER270/271 significantly prolongs survival of…
2017 American Transplant Congress
Ex Vivo Normothermic Perfusion of Isolated Segmental Porcine Bowel: A Novel Functional Model of the Small Intestine.
M. Hamed,¹ A. Barlow,¹ S. Khosla,¹ A. Sagar,¹ F. Gribble,² M. Murphy,³ G. Pettigrew,¹ E. Bolton,¹ J. Bradley,¹ M. Nicholson,¹ S. Hosgood,¹ K. Saeb-Parsy.¹
¹University Department of Surgery, Cambridge NIHR Biomedical Research Centre and NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Cambridge, Cambridgeshire, United Kingdom; ²Wellcome Trust – MRC Institute of Metabolic Science, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; ³MRC Mitochondrial Biology Unit, Cambridge, Cambridgeshire, United Kingdom
Introduction: There is a need for the development of suitable large animal models for research in gastroenterology and intestinal transplantation. Ex vivo normothermic perfusion (EVNP)…
2017 American Transplant Congress
Early Detection of Xenograft Rejection or Injury by Donor Derived Cell Free DNA in Pig to Baboon Cardiac Xenotransplantation.
A. Singh,¹ S. Agbor-Enoh,² J. Chan,¹ S. Groham,² P. Corcoran,¹ B. Lewis,³ M. Thomas,³ D. Ayares,⁴ K. Horvath,¹ H. Valantine,² M. Mohiuddin.¹
¹CSRP, NHLBI/NIH, Bethesda, MD; ²LTG, NHLBI/NIH, Bethesda, MD; ³ORS/NIH, Bethesda, MD; ⁴Revivicor, Inc, Blacksburg, VA
Detection of early graft rejection (EGR) is a great deal in the field of transplantation (Tx). A number of biomarkers have been used to determine…
2017 American Transplant Congress
Delayed Graft Function and Long-Term Graft Survival in DBD and DCD Kidney Recipients.
A. Massie, D. Segev.
JHU, Baltimore
Several single-center studies suggest that delayed graft function (DGF) is not associated with increased risk of graft loss in recipients of donation after cardiac death…
2017 American Transplant Congress
Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.
R. Gill,¹ M. Coulombe,¹ T. Kupfer,¹ K. Beard,¹ A. Burrack.²
¹Surgery and Immunology, University of Colorado Denver, Aurora, CO; ²University of Minnesota, Minneapolis, MN
Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…
2017 American Transplant Congress
No Gains in Long-Term Survival Following Liver Transplantation Over the Past Three Decades.
A. Rana,¹ M. Kueht,¹ J. Moffett,¹ N. Galvan,¹ R. Cotton,¹ J. Vierling,^1,2 A. Mindikoglu,^1,2 C. O'Mahony,¹ J. Goss.¹
¹Surgery, Baylor College of Medicine, Houston; ²Hepatology, Baylor College of Medicine, Houston
It is widely reported that outcomes have steadily improved in liver transplantation over the past 3 decades. The national benchmark of 1-year survival is now…
2017 American Transplant Congress
Impact of Belatacept Conversion on Kidney Transplant Function, Histology and Gene Expression.
P. Sanghi,¹ G. Gupta,¹ D. Kumar,¹ J. Reeve,² M. Levy,¹ A. Sharma,¹ H. Fattah,¹ P. Kimball,¹ H. Massey,¹ A. King,¹ P. Halloran.²
¹Virginia Commonwealth University, Richmond; ²Alberta Transplant Applied Genomics Center, Edmonton, Canada
Background: Belatacept (bela) might be an alternative to Calcineurin Inhibitors (CNI) in order to avoid presumed nephrotoxicity. In this study we assessed the impact of…
2017 American Transplant Congress
Co-Stimulation Blockade to Minimize and Withdraw Long Term Calcineurin Inhibitors (CNI) in Simultaneous Pancreas and Kidney Transplant (SPK).
P. Stock,¹ R. Mannon,² B. Armstrong,³ D. Ikle,³ M. Robian,⁴ Y. Morrison,⁴ J. Odorico,⁵ J. Fridell,⁶ A. Mehta,⁷ K. Newell.⁷
¹UCSF, San Francisco; ²UAB, Birmingham, AL; ³Rho Inc, Chapel Hill, NC; ⁴NIH/NIAID, Bethesda, MD; ⁵UW, Madison, WI; ⁶IU, Indianapolis, IN; ⁷Emory University, Atlanta, GA
The NIH multicenter CTOT-15 trial tested the hypothesis that use of belatacept (bela) could minimize or eliminate long-term CNI use in simultaneous pancreas and kidney…
2017 American Transplant Congress
Can Pre-Treatment CDC Titres Predict Graft Outcomes in HLA Incompatible Transplants?
A. Prasad,¹ A. Yuvaraj,¹ D. Briggs,² N. Krishnan.¹
¹Renal Transplant, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom; ²NHSBT, Birmingham, United Kingdom
Introduction: Complement Dependent Cytotoxic (CDC) (non-augmented) cross matching and Flow cytometric (FC) cross matching are two commonly used techniques to identify anti- Human Leucocyte Antigen…
2017 American Transplant Congress
Gene Expression Signature of Subclinical Allograft Kidney ABMR Compared to Clinical ABMR.
O. Aubert,¹ C. Lefaucheur,¹ S. Higgins,¹ L. Hidalgo,² J. Duong Van Huyen,¹ D. Viglietti,¹ X. Jouven,¹ D. Glotz,¹ C. Legendre,¹ P. Halloran,² A. Loupy.¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France; ²ATAGC, Edmonton, France
BackgroundAntibody-mediated rejection (ABMR) is characterized by a heterogeneous presentation. It occurs in clinically stable patients (sABMR) or in patients with allograft dysfunction (ABMR), but only…