2017 American Transplant Congress
ASP0113 Elicits an Immune Response in CMV-Seronegative Dialysis Patients: Comparison to Healthy Subjects.
Introduction: ASP0113 is a first-in-class, DNA-based vaccine in development for the prevention of CMV infection in at-risk hematopoietic cell transplant.Methods: A Phase 1, single-blind, parallel-group,…2017 American Transplant Congress
The Impact of Hepatitis C Treatment on GFR and Immunosuppression in Renal Transplant Recipients.
University of Maryland Medical Center, Baltimore, MD
Background: Renal transplant recipients (RTRs) with HCV are at an increased risk of graft rejection, making treatment of HCV in this population of the utmost…2017 American Transplant Congress
Usefulness of Valacyclovir Prophylaxis for Preventing Cytomegalovirus Infection After Anti-Thymocyte Globulin Treatment as Antirejection Therapy.
Anti-thymocyte globulin (ATG) treatment for acute T-cell mediated rejection (TCMR) can increase the risk of CMV infection. We purposed to evaluate the effect of valacyclovir…2017 American Transplant Congress
BKV Clearance Time Correlates with T-Cell Receptor Repertoire Shape and Exhaustion State of BKV-Specific T-Cells in Renal Transplant Patients with Severe BKV Infection.
Reactivation of the BK polyomavirus is known to lead to severe complications in kidney transplant patients. The current treatment strategy relies on decreasing the immunosuppression…2017 American Transplant Congress
Fate and Function of CD8+ T Cells Primed by Fetal Antigen During Pregnancy.
Background The long-term fate of maternal T cells primed by fetal antigen during pregnancy has not been well studied but may have significant impact for…2017 American Transplant Congress
Quantity and Functions of CD4–CD8– Double Negative (DN) αβ T Cells in Kidney Is MHC Dependent.
Johns Hopkins University, Baltimore, MD
Background: Prior studies have established important roles of CD4+ T cells, natural killer T cells, and CD4+CD25+FoxP3+ Tregs in kidney ischemia reperfusion injury (IRI) pathogenesis.…2017 American Transplant Congress
Low Level Early Onset De Novo DSA's May Not Portend Early Graft Dysfunction in Kidney Transplant Recipients.
Nephrology and Hypertension, Stony Brook Medicine, Stony Brook, NY
Background: The occurrence of anti-HLA de novo DSA (dnDSA) has been associated with the histological features of antibody-mediated rejection (ABMR) on kidney biopsy. The significance…2017 American Transplant Congress
Non-Donor-Specific Anti-HLA Antibodies Have an Adverse Impact in Kidney Graft Outcomes.
1CHP, Porto, Portugal; 2IPST, Porto, Portugal
Few studies have studied the impact of non-donor-specific antibodies (NDSA) in kidney transplantation (KT), with most showing no impact of these antibodies. As antibody-mediated graft…2017 American Transplant Congress
Clinical Experience with Novel Cephalosporin/Beta-Lactamase Inhibitor Combinations in the Treatment of Multidrug Resistant Pseudomonas aeruginosa and Carbapenem-Resistant Enterobacteriaceae in Solid Organ Transplant Recipients.
Purpose: To review clinical outcomes in organ transplant recipients (OTRs) treated with Ceftazidime/avibactam (C/A) and ceftolozane/tazobactam (C/T) for infections caused by Multidrug resistant Pseudomonas aeruginosa…2017 American Transplant Congress
The Incidence and Outcomes of Fever of Unknown Origin After Pancreas Transplantation.
1Houston Methodist Hospital, Houston, TX; 2Veloxis Pharmaceuticals, Cary, NC
Previous studies have shown that approximately 20% of febrile episodes in transplant recipients are not associated with infection. At our center, fever of unknown origin…
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