Am J Transplant, Volume 17, Suppl 3 Archives - Page 149 of 181 - ATC Abstracts

2017 American Transplant Congress
Regulation of T Cell Migration by Specifically Targeting Lymphotoxin β Receptor (LTβR)-Mediated Non-Canonical NFkB Signaling.
W. Piao, Y. Xiong, C. Brinkman, J. Bromberg.
UMB, Baltimore
Background:Selective recruitment of regulatory T cells (Treg) to draining lymph nodes is crucial for graft survival, and LTαβ-LTβR signaling is required to direct Treg into…
2017 American Transplant Congress
Induction of Delayed Renal Allograft Tolerance Using Only Clinically Available Reagents in Non-Human Primates.
K. Hotta, T. Oura, A. Dehnadi, S. Boskovic, M. Matsunami, I. Rosales, N. Smith, R. Colvin, A. Cosimi, T. Kawai.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Background: We have previously reported successful induction of renal allograft tolerance following a period of conventional immunosuppression (Delayed tolerance) using nonmyeloablative conditioning that included anti-CD154…
2017 American Transplant Congress
Validation of a Prediction Model for Cardiac Allograft Vasculopathy.
E. Kransdorf, T. Aintablian, M. Kittleson, J. Patel, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles
Introduction: Cardiac allograft vasculopathy (CAV) continues to limit the long-term success of heart transplantation. Although the progression of CAV can be slowed by tailored immunosuppression,…
2017 American Transplant Congress
Repeat Biopsies After the Diagnosis of BK Virus Associated Nephropathy: Importance of Integrating Clinical and Pathological Findings.
C. Drachenberg,¹ J. Papadimitriou,¹ R. Ugarte,² M. Mavanur,² B. Thomas,² C. Cangro,² N. Costa,² M. Weir,² A. Haririan.²
¹Pathology, University of Maryland School of Medicine, Baltimore, MD; ²Medicine, University of Maryland School of Medicine, Baltimore, MD
Early diagnosis of PV nephropathy(PyVAN) leads to overall improvements in the short term but sclerosing sequelae and risk for rejection (mainly antibody mediated) contribute to…
2017 American Transplant Congress
Apolipoprotein L1 & Chronic Kidney Disease Risk in Young Potential Living Kidney Donors.
J. Locke,¹ D. Sawinski,² R. Reed,¹ B. Shelton,¹ P. MacLennan,¹ V. Kumar,¹ S. Mehta,¹ R. Mannon,¹ R. Gaston,¹ B. Julian,¹ J. Carr,³ J. Terry,³ M. Kilgore,¹ A. Massie,⁴ D. Segev,⁴ C. Lewis.¹
¹University of Alabama at Birmingham, Birmingham; ²University of Pennsylvania, Philadelphia; ³Vanderbilt University, Nashville; ⁴Johns Hopkins University, Baltimore
Background: Living kidney donor selection practices have evolved from examining individual risk factors to a risk calculator incorporating multiple characteristics. Due to limited long-term data…
2017 American Transplant Congress
Binding of Antigens by Its Specific Antibodies Results in Exosome Formation Leading to Rejection of Syngeneic Murine Cardiac Grafts.
M. Sharma, W. Liu, M. Gunasekaran, S. Bansal, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix
Background: Antibody binding to its antigen can activate complement cascades leading to cell death. In addition, it can activate intracellular signals leading to rejection of…
2017 American Transplant Congress
The Unfunded OPTN/UNOS Mandate of Living Kidney Donor Follow-Up: Fewer Than 50% of Centers in Compliance.
M. Henderson, A. Thomas, A. Massie, X. Luo, A. Shaffer, C. Holscher, D. Segev.
Surgery, Johns Hopkins, Baltimore, MD
OPTN/UNOS began requiring 2-year living donor follow-up (LDF) in 2013. Current LDF, and changes associated with the new guidelines, have not been evaluated.METHODS: Using SRTR…
2017 American Transplant Congress
Immunodominant Donor Specific Antibody Reduction with Proteasome Inhibitor Based Treatment: Clinical Variability and Implications for Long Term Graft Survival.
A. Lichvar,¹ A. Leino,¹ S. Tremblay,¹ A. Shields,² B. Abu Jawdeh,¹ B. Hardy,¹ M. Anand,¹ M. Cuffy,¹ M. Cardi,¹ R. Alloway,¹ E. Woodle.¹
¹University of Cincinnati, Cincinnati; ²The Christ Hospital, Cincinnati
Proteasome inhibitor (PI) based regimens treat antibody mediated rejection (AMR) at least in part by eliminating donor specific antibody (DSA). iDSA response to PI-based therapy…
2017 American Transplant Congress
EPTS Is a Poor Predictor of Post-KT Mortality for Older Recipients.
M. McAdams DeMarco, X. Luo, A. Massie, D. Segev.
Johns Hopkins, Baltimore, MD
Background:The new kidney allocation system (KAS) is meant to better match longevity of recipients and allografts. The United Network for Organ Sharing (UNOS) decided that…
2017 American Transplant Congress
Effects of New KPD Histocompatibility Policy on Refusal Rate and Transplants.
R. Leishman,¹ M. Aeder,² M. Leffell,³ C. Murphey,⁴ N. Reinsmoen,⁵ S. Saidman,⁶ T. Sandholm,⁷ A. Toll,¹ A. Harper,¹ N. Turgeon.⁸
¹UNOS, Richmond, VA; ²Univ Hosp Med Ctr, Cleveland, OH; ³Johns Hopkins Univ, Baltimore, MD; ⁴SW Immunodiagnostics, San Antonio, TX; ⁵Cedars-Sinai Health, Los Angeles, CA; ⁶Mass Gen Hosp, Boston, MA; ⁷Carnegie Mellon Univ, Pittsburgh, PA; ⁸Emory Univ, Atlanta, GA
Background: Transplant centers commonly refuse kidney paired donation (KPD) match offers due to unacceptable crossmatch (XM). To reduce XM refusals a new OPTN KPD histocompatibility…