ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    The Polymer Pro-Drug APP-103 Mitigates I/R Injury and Improves Graft Function in a Pre-Clinical Renal Transplant Model.

    K. Minami,1,3 H. Uehara,1 A. Elkhal,1 S. Bae,3 J. Reder,2 B. Houser,2 P. Kang,3 S. Tullius.1

    1Transplant Surgery Division, Brigham and Women's Hospital, Boston, MA; 2Celdara Medical, LLC, Lebanon, NH; 3Beth Israel Deaconess Medical Center, Boston, MA

    Purpose: Ischemia-reperfusion injury (IRI) is the strongest non-HLA factor that augments allogenicity of transplanted organs. Damage subsequent to IRI is critically linked to an abundance…
  • 2017 American Transplant Congress

    Tacrolimus Dose Variability, CYP3A5 Genotype, and Acute Rejection in African American and European American Kidney Transplant Recipients.

    S. Seibert,1 D. Schladt,2 B. Wu,3 W. Guan,3 C. Dorr,2,7 D. Berglund,1 R. Remmel,4 A. Matas,5 R. Mannon,6 A. Israni,2,7 W. Oetting,1 P. Jacobson,1 For the DeKAF Genomics Investigators.

    1Dept of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota (UMN), Mpls, MN; 2Chronic Disease Research Group, Minneapolis Medical Research Foundation, Mpls, MN; 3Division of Biostatistics, School of Public Health, UMN, Mpls, MN; 4Dept of Medicinal Chemistry, College of Pharmacy, UMN, Mpls, MN; 5Division of Transplantation, Dept of Surgery, School of Medicine, UMN, Mpls, MN; 6Dept of Nephrology, University of Alabama, Birmingham, AL; 7Dept of Nephrology, Hennepin County Medical Center, School of Medicine, UMN, Mpls, MN

    Background: Poor immunosuppression with tacrolimus (TAC) after kidney transplantation contributes to the development of toxicity and loss of efficacy. We aimed to associate intra-patient TAC…
  • 2017 American Transplant Congress

    Renal Function Outcomes by HLA Mismatch in De Novo Kidney Transplant Recipients Receiving Everolimus PlusReduced-Dose Cyclosporine versus Mycophenolate Plus Standard-Dose Cyclosporine: 24-Month Subanalysis of A1202 Study.

    K. Yoshida,1 Y. Watarai,2 K. Nakagawa,3 O. Kamisawa.4

    1Kitasato University, Sagamihara, Japan; 2Nagoya Daini Red Cross Hospital, Nagoya, Japan; 3Ichikawa General Hospital, Tokyo Dental College, Ichikawa, Japan; 4Novartis Pharma K.K., Tokyo, Japan

    Purpose: High levels of human leukocyte antigen (HLA) mismatches are a key determinant of kidney allograft survival. Here, we present 24-month (M) subanalysis of the…
  • 2017 American Transplant Congress

    Anti-CD25mAb Sparing Immunosuppressive Regimen Suppressed Recurrence of Post-Transplant Focal Segmental Glomerular Sclerosis- A Single Center Experience.

    H. Harada, Y. Wada, N. Fukuzawa.

    Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan

    INTRODUCTION: The rate of recurrence of primary focal segmental glomerular sclerosis (FSGS) is problematic, because it often results in very early serious urinary protein secretion…
  • 2017 American Transplant Congress

    Early Exposure of Everolimus with and without Calcineurin Inhibitors.

    C. Felipe, A. Ferreira, T. Abait, A. Bessa, P. Ruppel, L. Hiramoto, M. Ivani, H. Tedesco, J. Medina- Pestana.

    Nephrology Division, Hospital do Rim, UNIFESP, São Paulo, SP, Brazil

    This study aimed to evaluate the effect of cyclosporine (CSA) or tacrolimus (TAC) on early exposure of everolimus (EVR).A cohort of 306 kidney transplant recipients…
  • 2017 American Transplant Congress

    Persistence/Progression of Early Banff Borderline Changes (BBC) Is Associated with Chronic Renal Allograft Damage and Can Be Predicted by B Cell Cytokine Profile.

    A. Cherukuri, A. Sharma, R. Mehta, S. Hariharan, D. Rothstein.

    UPMC, Pittsburgh

    The clinical significance of early histological BBC in kidney transplant recipients (KTR) is unclear. It is also unknown if biomarkers predict progression to acute rejection…
  • 2017 American Transplant Congress

    Muscle Mass Is Predictive of Mortality in Obese Renal Transplant Patients.

    J. Souweine,1,3 M. Le Quintrec,1 I. Szwarc,1 V. Pernin,1 G. Mourad,1 J. Cristol,2,3 J. Serre.1

    1Nephrology, University Hospital of Montpellier, Montpellier, France; 2Biochemistry, University Hospital of Montpellier, Montpellier, France; 3PhyMedExp, UMR CNRS 9214, INSERM U1046, University Hospital of Montpellier, Montpellier, France

    Introduction: The impact of obesity (body mass index [BMI] > 30 kg/m[sup2]) on kidney allograft outcomes is controversial. Recent studies found that obesity does not…
  • 2017 American Transplant Congress

    A Decade of Paediatric Kidney Transplantation in Children Weighing <20kg.

    P. Chandak,1 J. Stojanovic,2 F. Jamshaid,1 N. Mamode,1 F. Calder,1 J. Olsburgh,1 C. Callaghan,1 M. Drage,1 G. Koffman,1 S. Marks,3 N. Kessaris.1

    1Transplant Surgery, Guy's and St Thomas and Evelina Childrens and Great Ormond Street Hospitals, London, United Kingdom; 2Paediatric Nephrology, Evelina Childrens Hospitals, London, United Kingdom; 3Paediatric Nephrology and Transplantation, Great Ormond Street Hospitals, London, United Kingdom

    Introduction: Renal transplantation is the gold standard treatment for end-stage kidney disease. There are increased challenges in paediatric renal transplant recipients under 20kg, especially when…
  • 2017 American Transplant Congress

    Isolated Angiotensin II Receptor Type I Antibodies (AT1R) Are Not Associated with Active Antibody Mediated Rejection (ABMR) in Pediatric Renal Transplant Recipients.

    J. Choi, M. Haas, X. Zhang, O. Aubert, H. Pizzo, E. Kamil, K. Irene, S. Jordan, D. Puliyanda.

    Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA

    Intro: Donor specific antibodies (DSAs) detected post transplant are associated with ABMR and graft dysfunction. The role of non-HLA antibodies especially angiotensin II receptor type…
  • 2017 American Transplant Congress

    Incidence and Outcomes of Immediate Post-Operative Dialysis in Liver Transplantation.

    S. Nagai, M. Safwan, K. Collins, M. Rizzari, A. Yoshida, M. Abouljoud.

    Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI

    Aim: Although kidney dysfunction secondary to hepatorenal syndrome is expected to recover with liver transplant alone (LTA), patients with pre-transplant marginal kidney function may be…
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