Am J Transplant, Volume 17, Suppl 3 Archives - Page 136 of 181 - ATC Abstracts

2017 American Transplant Congress
Pediatric Liver Transplantation for Alpha-1 Antritrypsin Deficiency: A UNOS Database Analysis.
J. Jossen,¹ R. Annunziato,² J. McShane,² J. Chu,¹ R. Arnon.¹
¹Department of Pediatrics, Mount Sinai Hospital, New York, NY; ²Psychology, Fordham University, Bronx, NY
PurposeAlpha-1 Antritypsin Deficiency (ATD) is a heterogeneous disease, and is an important indication for liver transplantation (LT) in children. We examine the ATD population requiring…
2017 American Transplant Congress
Xenogeneic Lung Transplantation: Identifying Transgenes and Supportive Drug Treatments to Achieve Long-Term Survival.
L. Burdorf,¹ C. Laird,¹ N. O'Neill,¹ T. Zhang,¹ D. Parsell,¹ I. Tatarov,¹ A. Cimeno,² S. Sendil,¹ K. Thomas,¹ C. Phelps,² D. Ayares,² A. Azimzadeh,¹ R. Pierson III.¹
¹Surgery, University of Maryland, Baltimore, MD; ²Revivicor, Inc., Blacksburg, VA
Purpose: Recent progress in genetic engineering has facilitated generation of pigs expressing various multi-transgene and knock-out combinations. Which transgenes and what targeted drug treatments are…
2017 American Transplant Congress
Blood Tfh Cells Exhibit Impaired B Cell Help in Operationally Tolerant Patients.
R. Danger,¹ A. Chenouard,¹ M. Chesneau,¹ S. Castagnet,² P. Guérif,¹ N. Degauque,¹ M. Giral,¹ S. Brouard.¹
¹Inserm UMR 1064, Nantes University Hospital, Nantes, France; ²HLA Laboratory, Etablissement Français du Sang, Nantes, France
Introduction: Operationally tolerant (TOL) patients display a defect of B cell differentiation, with a deficiency in circulating plasma cells secreting antibodies, which could partly contribute…
2017 American Transplant Congress
Impact of Serum EDTA Treatment on Identification of Unacceptable Antigens for Kidney Transplant Candidates.
J. Xin, N. Brown, R. Upchurch, J. Weidner, S. Marino.
Pathology, University of Chicago Medicine, Chicago, IL
BACKGROUND AND AIMS: The prozone effect is one factor causing false negative reactions in HLA antibody testing. EDTA, which is commonly used to remove this…
2017 American Transplant Congress
Weekend Discharge and Early Hospital Readmission After Kidney Transplant: A Multi-Center Analysis.
M. Harhay,¹ Y. Jia,² H. Thiessen Philbrook,² B. Besharatian,³ R. Gumber,³ F. Weng,⁴ I. Hall,⁵ M. Doshi,⁶ B. Schroeppel,⁷ C. Parikh,² P. Reese.³
¹Drexel University College of Medicine, Philadelphia; ²Yale University, New Haven; ³University of Pennsylvania, Philadelphia; ⁴RWJ Barnabas Health, Livingston; ⁵University of Utah, Salt Lake City; ⁶Wayne State University, Detroit; ⁷Mt. Sinai Health System, New York
Background: Kidney transplant (KT) recipients with early hospital readmission (EHR, <30 days after discharge from KT) are at higher risk for poor post-KT outcomes. There…
2017 American Transplant Congress
Non-Directed Kidney Donor Candidate Referral, Care, and Attrition in an Online Portal.
R. Hays,¹ K. Schappe,¹ D. Kaufman,¹ D. Mandelbrot.²
¹Division of Transplant Surgery, University of Wisconsin Hospital and Clinics, Madison, WI; ²Division of Nephrology, Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI
When non-directed live kidney donation (NDD) was first described in the early 2000s, a high rate of inquiry per actual donor was noted. Since then,…
2017 American Transplant Congress
Perceived Patient Barriers for Kidney Transplant Evalution Among Transplant Center Staff.
L. McPherson, K. Lipford, R. Hamoda, J. Gander, S. Pastan, R. Patzer.
Emory University, Atlanta, GA
Background: The Southeastern United States has the lowest rates of kidney transplant in the nation. Disparities in transplant access among end stage renal disease (ESRD)…
2017 American Transplant Congress
Lung Preservation Solution Exposure at Cardiac Procurement Is Associated Increased Incidence of Coronary Arterial Vasculopathy.
H. Copeland,¹ V. Garcia,² A. Sima,² D. Baran,³ A. Mankind,⁴ G. Katlaps,¹ N. Lewis,⁴ B. Dharmaj,¹ J. Copeland.⁵
¹Cardiothoracic Surgery, McGuire VA Medical Center, Richmond, VA; ²Biostatistics, Virginia Commonwealth University, Richmond, VA; ³Cardiology, Beth Israel Medical Center Barnabas Health, Newark, NJ; ⁴Cardiology, McGuire VA Medical Center, Richmond, VA; ⁵Surgery, Division of Cardiothoracic Surgery, University of Arizona, Tucson, AZ
Purpose: To evaluate cardiac recipient survival and incidence of coronary artery vasculopathy (CAV) in recipient hearts that have been exposed to lung preservation solution, Perfadex.Methods:…
2017 American Transplant Congress
Exploring Differential Antibody Response to Bortezomib in Heart Transplantation.
K. Ghafourian, R. Hod-Dvorai, S. McCabe, N. Cool, M. Fine, M. Ackerman, J. Rich, J. Wilcox, E. Vorovich, A. Anderson, A. Tambur.
Northwestern University, Chicago, IL
Twelve heart transplant candidates (2013-2016) received Bortezomib (BTZ) for desensitization. Differential antibody (Ab) response was observed. BTZ cycles consisted of 4 injections of 1.3 mg/m2;…
2017 American Transplant Congress
CD16+ Monocytes and Skewed Macrophage Polarization Towards M2 Type Hallmark Heart Transplant Acute Cellular Rejection.
T. van den Bosch,¹ K. Caliskan,² M. Kraaij,¹ A. Constantinescu,² O. Manintveld,² P. Leenen,³ J. von der Thüsen,⁴ M. Clahsen-van Groningen,⁴ C. Baan,¹ A. Rowshani.¹
¹Internal Medicine and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands; ²Cardiology, Erasmus University Medical Center, Rotterdam, Netherlands; ³Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; ⁴Pathology, Erasmus University Medical Center, Rotterdam, Netherlands
Purpose: During acute heart transplant rejection, infiltration of lymphocytes and monocytes is followed by endothelial injury and eventually myocardial fibrosis. To date, no information is…