Am J Transplant, Volume 17, Suppl 3 Archives - Page 129 of 181 - ATC Abstracts

2017 American Transplant Congress
IgG Antibody Subclasses in Potential Renal Transplant Recipients with DSA, AHG-CDC CxM Negative and FxM Positive or Negative with Their Potential Donors.
A. Contreras, A. Casillas, L. Llorente, G. Lima, A. Arvizu, A. De Santiago, M. Vilatoba, J. Alberu, J. Arreola-Guerra.
Transplantation Departament, 1b Immunology Department, Inst Nal Ciencia Medicas y Nutricion SZ, Mexico City, Mexico
Background. In kidney transplant recipients, IgG3 and IgG4 DSA have been associated with shorter time to acute AMR and with later allograft injury (glomerulopathy &…
2017 American Transplant Congress
Effect of Epigenetic Modifications in Ischemia-Reperfusion-Injury Post Liver Transplantation: An Integrative Approach.
D. Bagchi, S. Bontha, M. Dozmorov, A. Fernandez, V. Mas, D. Maluf.
Surgery, UVA, Charlottesville; VCU, Richmond
Background Free radicals generated during ischemia reperfusion injury (IRI) might result in epigenetic modifications and gene expression (GE) changes affecting graft outcomes. Integrative analyses of…
2017 American Transplant Congress
Low-Dose Valganciclovir for Cytomegalovirus Prophylaxis in Intermediate Risk Renal Transplants: A Single Center Experience.
A. Baghban,¹ K. Belfield,² M. Azar,¹ E. Cohen,² M. Malinis.¹
¹Infectious Diseases, Yale University, New Haven, CT; ²Pharmacy, YNHH, New Haven, CT
IntroductionCurrent guidelines on cytomegalovirus (CMV) prophylaxis following organ transplant recommend using valganciclovir (VGCV) 900 mg daily for high (CMV D+/R-) and intermediate (CMV R+) risk…
2017 American Transplant Congress
Does EBV Viremia at Time of Transplant Have a Negative Impact on Transplant Outcomes?
P. Verghese, H. Balfour, D. Schmeling, J. Grimm, S. Chinnakotla, A. Matas.
University of Minnesota, Minneapolis
Being EBV antibody (Ab) positive at the time of transplant increases the risk of post-transplant lymphoproliferative disorder (PTLD) and is a significant threat to patient…
2017 American Transplant Congress
Willingness to Donate Organs Among Persons Living with HIV.
S. Halpern, K. Kumar, A. Nguyen, S. Rasmussen, S. Anjum, A. Massie, A. Tobian, D. Segev, J. Sugarman, C. Durand.
JHU, Baltimore, MD
HIV-to-HIV organ transplants could shorten waitlist times among both HIV-infected (HIV+) and uninfected (HIV-) individuals. However, it is unknown whether HIV+ individuals are willing to…
2017 American Transplant Congress
Mitochondrial Permeability Can Regulate Endothelial Cell Necroptosis and Promote Cardiac Allograft Rejection.
I. Gan,^1,2 J. Jiang,¹ D. Lian,¹ A. Jevnikar,^1,3 Z.-X. Zhang.^1,2
¹Matthew Mailing Centre for Translational Transplant Studies, Western University, London, ON, Canada; ²Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada; ³Department of Medicine, Western University, London, ON, Canada
Background: Transplant injury is invariably associated with programmed cell death (PCD) resulting in organ rejection. Many forms of PCD have been described including apoptosis, pyroptosis,…
2017 American Transplant Congress
HLA Class II Molecules Partner with TLR4 to Stimulate Endothelial Cell Activation and Proliferation.
Y.-P. Jin, E. Reed.
Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
Background: Transplant recipients developing donor specific HLA antibodies (DSA) are at a higher risk for acute and chronic antibody-mediated rejection (AMR). DSA contribute to the…
2017 American Transplant Congress
Phenotypic and Functional Assessment of T Cell Alloimmunity After Liver Transplantation.
T. Taner, M. Hansen, W. Park, M. Stegall.
Mayo Clinic, Rochester, MN
In addition to its metabolic functions, the liver is also an immunologically active organ. Liver transplant recipients are often maintained on less immunosuppression when compared…
2017 American Transplant Congress
IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-HLA Antibody (Ab), Resulting in Inhibition of Anti-HLA Ab-Mediated NK Cell Activation and Ab-Dependent Cell-Mediated Cytotoxicity (ADCC) in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts).
S. Ge, M. Chu, J. Choi, S. Louie, A. Kang, A. Vo, A. Peng, S. Jordan, M. Toyoda.
Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Background: Ab-mediated rejection (ABMR) is a major obstacle in HS KTx Pts. ADCC is a mechanism responsible for ABMR. IdeS cleaves all 4 human IgG…
2017 American Transplant Congress
Donor-Derived Cell-Free DNA Normal Range and Biological Variation Defined in a Reference Population.
J. Bromberg,¹ D. Brennan,² E. Poggio,³ D. Hiller,⁴ R. Woodward,⁴ J. Yee,⁴ J. Sninsky,⁴ R. Bloom.⁵
¹University of Maryland, Baltimiore, MD; ²Washington University, St. Louis, MO; ³Cleveland Clinic, Cleveland, OH; ⁴CareDx, Brisbane, CA; ⁵University of Pennsylvania, Philadelphia, PA
Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the circulating blood of transplant recipients has shown promise as a non-invasive biomarker of acute rejection. This analysis was…