Am J Transplant, Volume 17, Suppl 3 Archives - Page 104 of 181 - ATC Abstracts

2017 American Transplant Congress
Validation of a Prediction Model for Cardiac Allograft Vasculopathy.
E. Kransdorf, T. Aintablian, M. Kittleson, J. Patel, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles
Introduction: Cardiac allograft vasculopathy (CAV) continues to limit the long-term success of heart transplantation. Although the progression of CAV can be slowed by tailored immunosuppression,…
2017 American Transplant Congress
Repeat Biopsies After the Diagnosis of BK Virus Associated Nephropathy: Importance of Integrating Clinical and Pathological Findings.
C. Drachenberg,¹ J. Papadimitriou,¹ R. Ugarte,² M. Mavanur,² B. Thomas,² C. Cangro,² N. Costa,² M. Weir,² A. Haririan.²
¹Pathology, University of Maryland School of Medicine, Baltimore, MD; ²Medicine, University of Maryland School of Medicine, Baltimore, MD
Early diagnosis of PV nephropathy(PyVAN) leads to overall improvements in the short term but sclerosing sequelae and risk for rejection (mainly antibody mediated) contribute to…
2017 American Transplant Congress
Apolipoprotein L1 & Chronic Kidney Disease Risk in Young Potential Living Kidney Donors.
J. Locke,¹ D. Sawinski,² R. Reed,¹ B. Shelton,¹ P. MacLennan,¹ V. Kumar,¹ S. Mehta,¹ R. Mannon,¹ R. Gaston,¹ B. Julian,¹ J. Carr,³ J. Terry,³ M. Kilgore,¹ A. Massie,⁴ D. Segev,⁴ C. Lewis.¹
¹University of Alabama at Birmingham, Birmingham; ²University of Pennsylvania, Philadelphia; ³Vanderbilt University, Nashville; ⁴Johns Hopkins University, Baltimore
Background: Living kidney donor selection practices have evolved from examining individual risk factors to a risk calculator incorporating multiple characteristics. Due to limited long-term data…
2017 American Transplant Congress
Binding of Antigens by Its Specific Antibodies Results in Exosome Formation Leading to Rejection of Syngeneic Murine Cardiac Grafts.
M. Sharma, W. Liu, M. Gunasekaran, S. Bansal, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix
Background: Antibody binding to its antigen can activate complement cascades leading to cell death. In addition, it can activate intracellular signals leading to rejection of…
2017 American Transplant Congress
The Unfunded OPTN/UNOS Mandate of Living Kidney Donor Follow-Up: Fewer Than 50% of Centers in Compliance.
M. Henderson, A. Thomas, A. Massie, X. Luo, A. Shaffer, C. Holscher, D. Segev.
Surgery, Johns Hopkins, Baltimore, MD
OPTN/UNOS began requiring 2-year living donor follow-up (LDF) in 2013. Current LDF, and changes associated with the new guidelines, have not been evaluated.METHODS: Using SRTR…
2017 American Transplant Congress
Immunodominant Donor Specific Antibody Reduction with Proteasome Inhibitor Based Treatment: Clinical Variability and Implications for Long Term Graft Survival.
A. Lichvar,¹ A. Leino,¹ S. Tremblay,¹ A. Shields,² B. Abu Jawdeh,¹ B. Hardy,¹ M. Anand,¹ M. Cuffy,¹ M. Cardi,¹ R. Alloway,¹ E. Woodle.¹
¹University of Cincinnati, Cincinnati; ²The Christ Hospital, Cincinnati
Proteasome inhibitor (PI) based regimens treat antibody mediated rejection (AMR) at least in part by eliminating donor specific antibody (DSA). iDSA response to PI-based therapy…
2017 American Transplant Congress
EPTS Is a Poor Predictor of Post-KT Mortality for Older Recipients.
M. McAdams DeMarco, X. Luo, A. Massie, D. Segev.
Johns Hopkins, Baltimore, MD
Background:The new kidney allocation system (KAS) is meant to better match longevity of recipients and allografts. The United Network for Organ Sharing (UNOS) decided that…
2017 American Transplant Congress
Effects of New KPD Histocompatibility Policy on Refusal Rate and Transplants.
R. Leishman,¹ M. Aeder,² M. Leffell,³ C. Murphey,⁴ N. Reinsmoen,⁵ S. Saidman,⁶ T. Sandholm,⁷ A. Toll,¹ A. Harper,¹ N. Turgeon.⁸
¹UNOS, Richmond, VA; ²Univ Hosp Med Ctr, Cleveland, OH; ³Johns Hopkins Univ, Baltimore, MD; ⁴SW Immunodiagnostics, San Antonio, TX; ⁵Cedars-Sinai Health, Los Angeles, CA; ⁶Mass Gen Hosp, Boston, MA; ⁷Carnegie Mellon Univ, Pittsburgh, PA; ⁸Emory Univ, Atlanta, GA
Background: Transplant centers commonly refuse kidney paired donation (KPD) match offers due to unacceptable crossmatch (XM). To reduce XM refusals a new OPTN KPD histocompatibility…
2017 American Transplant Congress
DNA Methylation Dynamics from Ischemia/Reperfusion Injury to Long-Term Allograft Function.
V. Bontha,¹ D. Maluf,¹ M. Dozmorov,² D. Bagchi,¹ K. Archer,³ V. Mas.¹
¹Surgery, UVA, Charlottesville; ²VCU, Richmond; ³OSU, Columbus
Background: We hypothesize that following early graft damage (e.g., ischemia reperfusion injury) post-kidney transplantation (KT), the graft response to injury and repair involve changes in…
2017 American Transplant Congress
Technical Refinement to Prevent Hepatic Outflow Disturbance in Right Lobe Living Donor Liver Transplantation: Simplified One-Orifice Venoplasty.
J. Kim, D. Choi.
Department of Surgery, Catholic University of Daegu College of Medicine, Daegu, Republic of Korea
Middle hepatic vein (MHV) reconstruction is often essential to avoid hepatic congestion and serious graft dysfunction in living donor liver transplantation (LDLT). The aim of…