ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    High Regulatory T Cells Rate Early After Lung Transplantation Is Associated with Bronchiolitis Obliterans Syndrome Development.

    M. Durand,1,2 P. Lacoste,2,3 C. Brosseau,1,3 E. Durand,3 J. Loy,3 K. Henrio,2,3 R. Danger,1 P. Royer,3 A. Fourreau,3 A. Magnan,3,4 S. Brouard.1

    1INSERM U 1064, Center for Research in Transplantation and Immunology (CRTI), Nantes, France; 2Université de Nantes, Nantes, France; 3UMR INSERM 1087 CNRS 6291, Institut du Thorax, Nantes, France; 4Service de Pneumologie, Institut du Thorax, Nantes, France

    Despite treatment improvement, the bronchiolitis obliterans syndrome (BOS) affects more than 50% of the lung-transplant recipient in the 5 years post-transplantation and because it cannot…
  • 2017 American Transplant Congress

    Living and Deceased Donor Uterus Transplantation – The 2-Arm Czech Uterus Transplant Trial: The First Year Report with Four Cases Done so Far.

    J. Fronek,1 R. Chmel,2 L. Janousek,1 M. Novackova,2 J. Matecha,2 M. Olausson.3

    1Transplant Surgery Department, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic; 2Gynecology Department, University Motol Hospital, Prague, Czech Republic; 3Department of Surgery, Sahlgrenska University, Goteborg, Sweden

    Introduction: Uterus transplantation (UTx) may become another organ transplantation. There is very limited worldwide experience so far. The Czech uterus transplant trial started in 2015.…
  • 2017 American Transplant Congress

    Reduction of Recipient Cell Cross-Dressing with Donor MHC Molecules Prolongs Allograft Survival in Mice.

    J. Marino, H. Tector, B. Gonzalez-Nolasco, A. Lellouch, A. Harney, C. Cetrulo, Jr, J. Markmann, G. Benichou.

    Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA

    Cross-dressing of recipient cells with allogeneic MHC molecules carried by donor exosomes occurs regularly after transplantation. However, it is still unknown whether this phenomenon plays…
  • 2017 American Transplant Congress

    Maternal Risks and Pregnancy Outcomes After Kidney Transplantation: A Single Center Experience.

    A. Devresse,1 C. Jassogne,1 C. Hubinont,2 M. de Meyer,3 M. Mourad,3 E. Goffin,1 N. Kanaan.1

    1Nephrology Unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium; 2Obstetric Unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium; 3Renal and Pancreatic Transplantation Unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium

    IntroductionPregnancies in kidney-transplanted women are at high-risk compared to the general population. The aim of this study was to assess the obstetric complications, delivery outcomes,…
  • 2017 American Transplant Congress

    The Safety and Efficacy of Directly-Acting Antivirals with or without Ribavirin for HCV Genotype 1 Infection: A Systematic Review and Meta-Analysis.

    Z. Guo, J. Gu, X. He, G. Chen.

    The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    Previous studies have reported that ribavirin-free regimens are effective for treating chronic hepatitis C virus genotype 1 infection. However, the efficacy and safety of ribavirin-free…
  • 2017 American Transplant Congress

    HCV+ Waitlist Candidates More Likely to Die Waiting for Kidney Transplant from HCV- Donor.

    B. Shelton,1 D. Sawinski,2 S. Mehta,1 R. Reed,1 P. MacLennan,1 J. Locke.1

    1University of Alabama at Birmingham, Birmingham; 2University of Pennsylvania, Philadelphia

    Background: HCV-infected ESRD patients derive a significant survival benefit from kidney transplantation (KT) over remaining on dialysis. Given the high mortality rates on dialysis and…
  • 2017 American Transplant Congress

    Access to Simultaneous Pancreas and Kidney Transplant (SPK) Should Not Be Restricted to BMI > 28.

    M. Laftavi, A. Gruessner, V. Whittaker, Z. Acun, O. Pankowycz, R. Gruessner.

    SUNY Upstate Medical University, Syracuse, NY

    Background: Currently, UNOS guidelines require that uremic, insulin-dependent type 1 diabetic patients have a body mass index (BMI) < 28m/kg2 in order to be eligible…
  • 2017 American Transplant Congress

    Tolerant Pediatric Liver Transplant (LT) Recipients (TOL) from WISP-R (NCT00320606) Split into Two Phenotypically Distinct Groups by PD1 Expression on CD4+ T Cells at Baseline, Prior to Immunosuppression Withdrawal (ISW).

    B. Burrell,1 S. Feng,2 N. Bridges,3 U. Ekong,4 S. Kanaparthi,1 A. Kirk,5 A. Long,1 K. Spain,6 L. Stempora,5 L. Turka,1 N. Tchao.1

    1ITN, Bethesda; 2UCSF, San Francisco; 3NIAID, Bethesda; 4Yale, New Haven; 5Duke, Durham; 6Rho, Chapel Hill

    Background: Combinations of cell surface markers such as PD1, CD57, and/or KLRG1 identify T cells that may fail to respond to cognate antigen challenge –…
  • 2017 American Transplant Congress

    Acute Mouse CMV Infection Abrogates Transplant Tolerance by Modulating Myeloid Cell Differentiation and Function: A Possible Role for Transcription Factor RORγt.

    A. Dangi,1 L. Zhang,1 X. Zhang,2,3 Z. Zhang,2,3 X. Luo.1,2,3

    1Nephrology and Hypertension, Northwestern University, Chicago, IL; 2Comprehensive Transplant Center, Northwestern University, Chicago, IL; 3Comprehensive Transplant Center, Northwestern University, Chicago, IL

    Cytomegalovirus (CMV) infection has long been associated with graft-dysfunction and rejection in transplant-recipients. Nevertheless, precise understanding of underlying molecular mechanisms remains unclear. Here, we investigated…
  • 2017 American Transplant Congress

    BK Virus Infection and Risk of Urinary Tract Cancers Among Kidney Transplant Patients in the Transplant Cancer Match Study.

    G. Gupta,1 S. Kuppachi,2 R. Kalil,2 C. Buck,3 C. Lynch,2 E. Engels.3

    1Virginia Commonwealth University, Richmond; 2University of Iowa, Iowa City; 3National Cancer Institute, Bethesda

    Background: Recent case series describe expression of BK virus (BKV) in tumor tissue obtained from renourinary cancers in kidney transplant recipients (KTRs). Thus, BKV may…
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