ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    An Investigation of Biopsy-Proven De Novo Autoimmune Hepatitis After Hepatitis C Clearance with Direct Acting Antivirals in Liver Transplant Patients.

    R. Sigireddi, J. Moffett, M. Kueht, R. Ackah, A. Rana, C. O'Mahony, J. Goss, S. Dhingra, S. Khaderi.

    Department of Abdominal Transplantation, Baylor College of Medicine, Houston, TX

    Direct acting antivirals (DAAs) for hepatitis C virus (HCV) have been widely prescribed to post-liver transplant patients for HCV clearance and are believed to be…
  • 2017 American Transplant Congress

    Shared Decision Aid to Decipher Long-Term Treatment Risks for End Stage Renal Disease Patients.

    J. Gander, A. Manatunga, K. Jacob Arriola, S. Pastan, R. Patzer.

    Emory University, Atlanta, GA

    Kidney transplantation is the preferred treatment for end stage renal disease (ESRD) compared to dialysis. The incidence of ESRD continues to increase while the gap…
  • 2017 American Transplant Congress

    The Impact of Tacrolimus and MPA Derivative Immunosuppression on Acheived GFR in Recipients without Rejection: A Comparison of GFR of Living Donor Recipient Pairs at Six Months Post-Transplant.

    D. Keith.

    Medicine, Division of Nephrology, Sacred Heart Hospital, Pensacola, FL

    Analysis of the difference in estimated GFR (eGFR) of living donor recipient pairs at six months post-transplant showed that increased use of tacrolimus and MPA…
  • 2017 American Transplant Congress

    Biomarkers of Epithelial-Mesenchymal Transition (EMT) in Chronic Allograft Nephropathy: Potential for Early Detection and Development of Novel Therapeutic Agents.

    S. Kanangat, R. Miller, S. Rezaeian, H. Eldib, D. Cimbaluk, C. Fhied, I. Kurbegovic-Skaljic, M. Prod, J. Borgia, M. Flaws, D. Castillo, R. DeCresce.

    Pathology, BioChemistry and Medical Laboratory Sciences, Rush University Medical Center, Chicago, IL

    Purpose: To detect markers and novel treatment targets related to fibrogenesis and eventual graft loss by focusing on Epithelial Mesenchymal transition (EMT) which requires understanding…
  • 2017 American Transplant Congress

    Even Non-Donor-Specific HLA-Antibodies Are Associated with a Progressive Decline in Kidney Transplant Function.

    T. Mueller, K. Gerritsen, R. van Breemen, B. Ruesi, S. von Moos, P. Cippa.

    University Spital Zuerich, Zuerich, Switzerland

    Donor-specific anti-HLA-Antibodies (DSA) have been shown to be associated with antibody-mediated rejection episodes and a poorer long-term kidney graft function. The impact of anti-HLA-antibodies without…
  • 2017 American Transplant Congress

    Kidney Waitlist Management: The Readiness Model of Predicting Transplants Under the Kidney Allocation System.

    N. Elias, B. Kimball, L. Walsh, D. Wojciechowski, J. Markmann, E. Heher.

    Transplant Center, Massachusetts General Hospital, Boston, MA

    Based on the Organ Procurement and Transplantation Network data, between 2001 and 2016 the national kidney wait-list has grown from 51,271 to 100,791 (97%). At…
  • 2017 American Transplant Congress

    It's Never too Early to Test: Frequent Anti-A2 Titer Monitoring in Blood Group B Patients is Necessary.

    S. Radomski, S. Rosen-Bronson, B. Diedrich, A. Langeberg, D. Li, M. Awwad, M. Grafals, M. Cooper, A. Gilbert.

    Medstar Georgetown Transplant Institute, Washington, DC

    Introduction:With the implementation of the new Kidney Allocation System (KAS), deceased donor transplants from blood group A2 donors can now be implanted into blood group…
  • 2017 American Transplant Congress

    Tacrolimus Appears to Be a Protective Factor for De Novo DSA Formation in Non-Sensitized Kidney Transplant Patients.

    M. Marron-Wojewodzki,1 I. Szwarc,1 C. Rene,2 G. Mourad,1 M. Le Quintrec.1,3

    1Department of Nephrology, Dialysis and Transplantation, Hôpital Lapeyronie, Montpellier, France; 2Departement of Immunology, Hôpital Saint Eloi, Montpellier, France; 3Inserm U1183,, IRMB,Hôpital Saint Eloi, Montpellier, France

    Background.Development of de novo donor specific antibodies (dnDSA) concerns about 10% of patients within the first year following kidney transplantation and reach about 20% within…
  • 2017 American Transplant Congress

    Contribution of New Generation Sequencing to CMV Resistance Analysis in Renal Transplant Recipients (on Behalf of the CMV Resist Group).

    C. Danthu,1 M. Gomes-Mayeras,1 D. Andouard,2 E. Munteanu,1 R. Moulinas,1,4 G. Ligat,2 S. Hantz,1,2 J. Rerolle,3 F. Garnier,1 M. Essig,3 S. Alain.1,2,4

    1National Reference Center for CMV-Virology, CHU Limoges, Limoges, France; 2UMR Inserm 1092, Université Limoges, Limoges, France; 3Nephrology, CHU Limoges, Limoges, France; 4GenoLim/Biscem Genomic Platform, Université Limoges, Limoges, France

    Results from the French Cohorts 2006-2010 and OrphaVic (NCTNCT02067169) indicates that fifty percent of graft failures in renal recipients infected by HCMV after treatment with…
  • 2017 American Transplant Congress

    mTOR Inhibition Diminishes Peripheral Blood CD8+CD28–CD38hi Effector/Memory T Cells and Facilitates Resolution of Belatacept-Refractory Kidney Rejection.

    C. Castro-Rojas,1 A. Godarova,1 A. Leino,2 R. Alloway,2 M. Jordan,3 E. Woodle,2 D. Hildeman.1

    1Division of Immunobiology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH; 2Division of Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH; 3Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Research Foundation, Cincinnati, OH

    Belatacept, a CD28-CD80/86 blocker, was approved by the FDA to provide immunosuppression without nephrotoxicity or cardiovascular and metabolic adverse effects. As part of our multi-center…
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