Am J Transplant, Volume 17, Suppl 3 Archives - Page 10 of 181 - ATC Abstracts

2017 American Transplant Congress
The Effiency and Safety of Chemotherapy for Urothelial Carcinoma in Post-Kidney Transplanted Patients.
Y. Zhu, J. Lin.
Urology, Capital Medical University Beijing Friendship Hospital, Beijing, China
Objective: According to our published data, upper tract urothelial carcinoma (UTUC) is the predominant malignancy among Chinese renal transplanted patients. This is quite different from…
2017 American Transplant Congress
Aryl Hydrocarbon Receptor Regulates Myeloid Derived Suppressor Cells by Activating the ERK Signaling in a Murine Cardiac Transplantation Model.
T. Nakamura, K. Masuda, N. Yoshimura.
Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
There is a growing evidence that Myeloid-derived suppressor cells (MDSCs) have a crucial role in organ transplantation; however, the detail condition where MDSCs are sufficiently…
2017 American Transplant Congress
CTLA4-Ig in Combination with FTY720 Reduces the Frequency of Memory Alloreactive T Cells and Promotes Heart Allograft Survival in Sensitized Recipients.
S. Khiew,¹ J. Yang,¹ J. Young,¹ J. Chen,¹ Q. Wang,¹ D. Ying,¹ V. Vu,¹ M. Miller,² R. Sciammas,³ M.-L. Alegre,² A. Chong.¹
¹Section of Transplantation, Department of Surgery, University of Chicago, Chicago, IL; ²Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL; ³Center for Comparative Medicine, University of California, Davis, CA
Despite recent evidence of improved graft outcomes and safety, high incidence of early acute cellular rejection with belatacept has limited its use in clinical transplantation.…
2017 American Transplant Congress
Induced Pluripotent Stem Cell (iPS) Derived Schwann Cells to Enhance Functional Recovery Following Nerve Injury and Limb Allotransplantation.
B. Kern,¹ K. Sarhane,² Z. Ibrahim,² B. Mukherjee-Clavin,³ J. Budihardjo,² C. Cashman,³ K. Krick,⁴ S. Schneeberger,¹ W. Lee,² H.-Q. Mao,⁴ G. Lee,³ G. Brandacher.²
¹Operative Medicine, Innsbruck Medical University, Innsbruck, Austria; ²Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ³Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD; ⁴Materials Science and Engineering, Johns Hopkins University School of Medicine, Baltimore, MD
Background Stem cell therapies have provided new aspects for functional recovery. A novel cell-based approach utilizing human induced Pluripotent Stem Cell-derived Schwann Cells (iPSC-SCs) supported…
2017 American Transplant Congress
Noninvasive Renal Transplant Graft Monitoring in Single Institution Using Cell-Free DNA in Recipient Plasma via Insertion-Deletion Allele Polymorphism.
Y. Goh,¹ S. Ho,² L. Raman,¹ V. Anantharaman,³ T. Goh,³ S. Koay,² H. Tiong.¹
¹Urology, National University Hospital, Singapore, Singapore; ²Laboratory Medicine, National University Hospital, Singapore, Singapore; ³Nephrology, National University Hospital, Singapore, Singapore
IntroductionThere is an unmet clinical need in renal transplantation towards early detection of donor organ damage. Serum creatinine(SCr) and biopsies are not ideal.Cell-free donor DNA(cfdDNA)…
2017 American Transplant Congress
Next-Generation Sequencing-Based Exosome MicroRNA Profiling for Specific Identification of Islet Damage.
P. Saravanan,¹ J. Gu,¹ X. Wang,¹ P. Nguyen,¹ G. Yoshimatsu,¹ M. Lawrence,¹ B. Naziruddin.²
¹Baylor Scott and White Research Institute, Dallas, TX; ²Baylor Simmons Transplant Institute, Dallas, TX
Introduction: A significant mass of intraportally transplanted islets undergo damage due to various stress conditions including hypoxia and inflammation. Development of innovative ultrasensitive tests to…
2017 American Transplant Congress
ERK and HIF1 Play a Major Role in Hypothermic Protection Against Renal Ischemia-Reperfusion Injury.
K. Lee,¹ J. Jeong,² D. Choi,¹ K. Na,¹ H. Bae,¹ Y. Ham.¹
¹Chungnam National University, Nephrology, Daejeon, Korea; ²Chungnam National University, Department of Medical Science, Daejeon, Korea
Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…
2017 American Transplant Congress
High Risk Renal Transplant Recipients on Steroid Free Immunosupression Regimen. Indiana University Experience.
O. Adebiyi, S. Hussain, D. Mishler, W. Goggins, M. Yaqub, T. Taber, A. Sharfuddin.
Renal Transplant, Indiana University School of Medicine, Indianapolis, IN
Background : Immunologic risk often influence the choice immunosuppressive regimen used in renal transplant recipient. Patient with positive flow cytometry crossmatch (FCXM) or presence of…
2017 American Transplant Congress
Population Pharmacokinetic Profiling of Tacrolimus in Renal Transplant Recipients (RTRs) Taking Diltiazem.
P. Trevillian,^1,2,3 M. Heer,^1,2 S. Ainsworth,¹ A. Hibberd.^1,2,3
¹Newcastle Transplant Unit, John Hunter Hospital, Newcastle, NSW, Australia; ²University of Newcastle, Newcastle, NSW, Australia; ³Hunter Transplant Research Foundation, Hunter Medical Research Institute, Newcastle, NSW, Australia
Background: Over the past 6 years we have prospectively used pharmacokinetic (PK) profiling of Tacrolimus (TAC) in “stable” RTR's to individualise future dosing. This study…
2017 American Transplant Congress
Conversion from Calcineurin Inhibitor to Sirolimus in Kidney Transplantation Recipients with Malignancy.
J. Yoon, S. Kang, S. Kim, C. Baeck, H. Kim, S.-K. Park.
Nephrology, Asan Medical Center, Seoul, Republic of Korea
Background: Kidney transplant recipients are at an increased risk of malignancy for various reasons, such as the chronic use of calcineurin inhibitor (CNI). Sirolimus (SRL),…