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American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Transplanting Hepatitis C Kidneys into Negative KidnEy Recipients [THINKER] Trial.

    D. Goldberg, E. Blumberg, R. Reddy, S. Nazarian, V. Van Deerlin, J. Trofe-Clarke, M. Levine, D. Sawinski, R. Bloom, P. Abt, P. Reese.

    University of Pennsylvania, Philadelphia

    Background: More than 500 kidneys from HCV+ deceased donors are discarded each year, even though direct acting antiviral therapies have cure rates exceeding 95%. We…
  • 2017 American Transplant Congress

    Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.

    M. Manook,1,2 J. Kwun,1 J. Yoon,1 K. Samy,1 A. MacDonlad,1 H. Xu,1 R. Smith,3 S. Sacks,3 A. Dorling,3 N. Mamode,2 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Renal and Transplant, Guy's and St Thomas's NHS Foundation Trust, Sondon, United Kingdom; 3MRC Centre for Transplantation, London, United Kingdom

    Introduction:Thrombotic microangiopathy (TMA) is a phenomenon observed in antibody-mediated rejection (AMR) of the kidney transplant, particularly in highly sensitized individuals. Following promising data in a…
  • 2017 American Transplant Congress

    To Accept or Not Accept, That Is the Question: Donor Heart Selection Process and Outcome of Discarded Organs Transplanted in Another Center.

    A. Aliabadi-Zuckermann,1 J. Goekler,1 A. Kaider,2 J. Riebandt,1 R. Moayedifar,1 E. Osorio,1 T. Haberl,1 G. Laufer,1 J. Smits,3 A. Zuckermann.1

    1Cardiac Surgery, Medical University of Vienna, Vienna, Austria; 2Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria; 3Eurotransplant Foundation, Leiden, Netherlands

    Purpose: The decision making process to accept a donor heart is very complicated, subjective and less associated with evidence based decisions. In this analysis we…
  • 2017 American Transplant Congress

    Blood Transfusion Induced Donor Specific Antibodies Are Associated with Rejection and Graft Failure.

    S. Hassan,1 F. Regan,2,3 C. Brown,4 A. Harmer,3 N. Anderson,3 P. Brookes,5 D. Taube,1 M. Willicombe.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Haematology, Imperial College Healthcare NHS Trust, London, United Kingdom; 3NHS Blood and Transplant, London, United Kingdom; 4Histocompatibility and Immunogenetics, NHS Blood and Transplant, London, United Kingdom; 5Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom

    Introduction: Although it is well known that blood transfusions post-transplant are associated with the development of both HLA and donor specific antibodies [DSAs] and a…
  • 2017 American Transplant Congress

    HLA Eplet Mismatches Predict DSA Formation, Graft Survival, and Re-Transplantation Rate in Pediatric Renal Transplantation.

    M. Sypek,1,2 S. Hiho,3 L. Cantwell,3 P. Hughes,2 A. Le Page,4 J. Kausman.1

    1Royal Children's Hospital, Melbourne, Australia; 2Royal Melbourne Hospital, Melbourne, Australia; 3Victorian Transplant and Immunogenetics Service, Melbourne, Australia; 4Monash Children's Hospital, Melbourne, Australia

    The potential benefits of HLA epitope based matching are greatest for pediatric recipients, however, there is little published data on the association of epitope mismatches…
  • 2017 American Transplant Congress

    Assessing Self-Efficacy During the Transition from Pediatric to Adult Liver Transplant Care.

    J. Bilhartz, M. Lopez, S. Eder, E. Fredericks.

    University of Michigan, Ann Arbor, MI

    Purpose: As part of ongoing quality improvement efforts, this project aimed to investigate changes in self-efficacy among adolescent / young adult liver transplant recipients participating…
  • 2017 American Transplant Congress

    Penis Transplantation: First U.S. Experience.

    D. Ko, K. Li, H. Salinas, I. Schol, M. Treiser, F. McGovern, A. Feldman, B. Bojovic, J. Winograd, M. Grant, R. Ehrlichmann, C. Tanrikut, J. Lee, G. Choy, R. Liu, I. Rosales, R. Colvin, K. Eberlin, C. Cetrulo, Jr.

    Massachusetts General Hospital, Boston, MA

    STUDY PURPOSE: Penis transplantation represents a new paradigm in restoring function and anatomic appearance following genitourinary tissue loss. To date, only two penis transplants have…
  • 2017 American Transplant Congress

    Accelerated Rejection of Secondary Third Party Allografts in Older Recipients Is Facilitated by an Augmented Innate Immune Response.

    T. Heinbokel, K. Minami, A. Elkhal, S. Tullius.

    Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Accumulating evidence acknowledges the central relevance of aging and chronic antigen exposure in shaping the balance of innate and adaptive immunity. Here, we assessed whether…
  • 2017 American Transplant Congress

    Ambulatory Antibiotic Utilization and Outcomes in an Adult Kidney Transplant Population: A Pharmacovigilance Analysis.

    L. Avery, C. Fominaya, R. Crawford, D. Taber.

    Pharmacy, Ralph H Johnson VAMC, Charleston, SC

    Antibiotics (abx) are commonly prescribed to kidney transplant (KTX) recipients in the outpatient setting. There is limited data assessing the safety and outcomes associated with…
  • 2017 American Transplant Congress

    Use of Ledipasvir/Sofosbuvir with or without Ribavirin in Patients Post-Liver Transplant: Evaluation of Real-World Datasets.

    S. Flamm,1 M. Charlton,2 M. Manns,3 M. Prieto,4 I. Fernandez,5 M. Londono,6 R. Kwok,7 C. Smith,8 S. Lee,9 H. Ngo,9 A. Osinusi,9 A. Copans,9 L. Rossaro,9 M. Shoreibah,10 O. Massoud,10 M. Curry,11 M. Bourliere.12

    1Northwestern University, Chicago; 2Intermountain Medical Center, Murray; 3Hannover Medical School, Hannover, Germany; 4Hospital Universitari I Politecnic La Fe, Valencia, Spain; 5Hospital Universitario 12 de Octubre, Madrid, Spain; 6Servicio de Hepatología. Hospital Clinic, Barcelona, Spain; 7Walter Reed National Military Medical Center, DC; 8Medstar Georgetown University Hospital, Georgetown; 9Gilead Sciences, Inc., Foster City; 10University of Alabama Birmingham, Birmingham; 11Beth Israel Deaconess Medical Center, Boston; 12Hospital Saint Joseph, Marsielle, France

    PURPOSE: Post-liver transplant(LT) patients with HCV are considered a difficult-to-treat population. Ledipasvir/sofosbuvir(LDV/SOF) +ribavirin(RBV) for 12 weeks is approved in GT1 LT recipients based on the…
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