ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Non-Invasive Detection of Rejection with ImmunoPET Imaging.

    D. Mathews,1 K. Lindsay,2 P. Santangelo,2 Y. Dong,1 J. Tso,3 A. Adams.1

    1Department of Surgery, Emory University, Atlanta, GA; 2Department of Biomedical Engineering, Georgia Tech, Atlanta, GA; 3JN Biosciences LLC, Mountain View, CA

    Current approaches to detect and diagnose rejection are retrospective and/or invasive. These methods assess the extent of end organ damage by insensitive and non-specific measures…
  • 2017 American Transplant Congress

    Induction of Sensitization and Resistance to Transplant Tolerance by Allogeneic Pregnancy.

    A. Suah,1 J. Young,1 S. Hsu-Wei Khiew,1 Q. Wang,1 D. Yin,1 M.-L. Alegre,2 A. Chong.1

    1Department of Surgery, University of Chicago, Chicago, IL; 2Department of Medicine, University of Chicago, Chicago, IL

    Background: Clinical data suggest allogeneic pregnancy is a sensitizing event; yet, recent data from mouse models suggest it induces fetal-specific regulatory T cell (Treg) expansion…
  • 2017 American Transplant Congress

    Clinical Correlation of Endomyocardial Biopsies Molecular Profiling: Taking Rejection Diagnosis Beyond Histology.

    L. Potena,1 L. Borgese,1 A. Gaudenzi,1 V. Agostini,1 J. Reeve,2 M. Masetti,1 F. Grigioni,1 O. Leone,1 P. Halloran.

    1University of Bologna, Bologna, Italy; 2Alberta Transplant Applied Genomics Centre, Edmonton, Canada

    Histology grading of endomyocardial biopsies (EMB), the standard for diagnosing T-cell-mediated (TCMR) and antibody-mediated (ABMR) rejection, has serious issues with reproducibility (Transplantation 94 (11):1172177, 2012)…
  • 2017 American Transplant Congress

    Calibration of BK Virus Nucleic Acid Amplification Testing to the 1st WHO International Standard for BK Virus.

    S. Tan,1 S. Milligan,2 M. Sahoo,3 N. Taylor,2 B. Pinsky.1,2,3

    1Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA; 2Clinical Virology Laboratory, Stanford Health Care, Stanford, CA; 3Department of Pathology, Stanford University School of Medicine, Stanford, CA

    Significant inter-assay variability in the quantification of BK virus (BKV) DNA has limited the broad applicability of thresholds for the management of BKV infection in…
  • 2017 American Transplant Congress

    Early Acute Cellular Rejection(eACR) as a Marker of Immunologic Competency Following Liver Transplantation(LT).

    V. Kirchner, A. Bandgdiwala, D. Vock, M. Hassan, R. Kandaswamy, J. Lake, N. Lim, A. Mahgoub, E. Minja, A. Pugalenthi, B. Sengupta, O. Serrano, J. Thompson, W. Payne, T. Pruett, S. Chinnakotla.

    University of Minnesota, Minneapolis, MN

    Background:Historically eACR did not adversely impact patient survival(PS). Since infection(Ifx) is major cause of death(COD) among LT recipients, we hypothesized that eACR is marker of…
  • 2017 American Transplant Congress

    CD4 T Cell Migration Across Lymphatic Endothelium Is Enhanced by Sphingosine 1-Phosphate (S1P) and Differentially Regulated by S1P Receptors (S1PR).

    Y. Xiong,1 C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1UMB, Baltimore; 2UM, Minneapolis

    Introduction: S1PR1 drives T cells to migrate from thymus to blood, and from lymph node (LN) to efferent lymphatics. Whether S1PR1 or other S!PRs regulate…
  • 2017 American Transplant Congress

    Increasing Organ Supply in the US: A Systematic Review of Presumed Consent vs. Informed Consent (2006-2016).

    M. Ahmad,1 A. Hanna,1 A. Mohamed,1,2 R. Mhaskar,1 T. Jarmi,1,3 A. Schlindwein,4 C. Pley,4 I. Bahner.1

    1University of South Florida Morsani College of Medicine, Tampa, FL; 2Stetson University College of Law, Gulfport, FL; 3Transplant & Specialty Services, Tampa General Hospital, Tampa, FL; 4University of Cambridge School of Clinical Medicine, Cambridge, Cambridgeshire, United Kingdom

    Purpose: Literature was systematically reviewed from 2006 to 2016 to assess the effectiveness of presumed consent vs. informed consent on increasing the deceased donor organ…
  • 2017 American Transplant Congress

    Endocapillary NK Cells Are Increased in Indication Renal Transplant Biopsies with Antibody and T Cell Mediated Rejection.

    A. Shammout, J. Barnes, E. Farkash.

    Pathology, University of Michigan Medical School, Ann Arbor, MI

    Detection of NK cell transcripts in renal transplant biopsies is associated with antibody mediated rejection (AMR). Similarly, quantification of endocapillary NK cells in paraffin tissue…
  • 2017 American Transplant Congress

    One-Year Graft and Patient Survival of Deceased Donor Kidney Transplants Under KAS.

    A. Wilk,1 D. Stewart,1 M. Aeder,2 A. Kucheryavaya,1 D. Klassen.1

    1United Network for Organ Sharing, Richmond, VA; 2University Hospitals Cleveland Medical Center, Cleveland, OH

    Background: The new kidney allocation system (KAS) was implemented on 12/4/14 and led to more transplants for highly sensitized and long-term dialysis patients. Clinical characteristics…
  • 2017 American Transplant Congress

    Comparing the Role of Post-Transplant Readmissions and Bed Days on Total One Year Cost of Care.

    W. Bannister,1 M. Schnitzler,2 J. Tao,1 A. Bonagura,1 B. Laihinen,1 F. Irwin,1 C. Horstman.1

    1Complex Medical Conditions, Optum, UnitedHealth Group, Eden Prairie, MN; 2Surgery, St. Louis University, St. Louis, MO

    This study examines the marginal impact of readmissions and total bed days during the 90-day period following transplant in order to better understand drivers of…
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