ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Gene Editing of Keap1/Nrf2 in Human T Cells Using CRISPR-Cas9 to Improve Outcome from Ischemia Reperfusion Injury and Other T Cell Mediated Diseases.

    S. Noel,1 S. Lee,1 M. Sadasivam,2 A. Hamad,2 H. Rabb.1

    1Department of Medicine, Johns Hopkins University, Baltimore, MD; 2Department of Pathology, Johns Hopkins University, Baltimore, MD

    Background: T lymphocytes are important mediators of ischemia reperfusion injury (IRI) during organ transplantation. Using genetically engineered mice, we demonstrated that augmentation of Nrf2 dependent…
  • 2017 American Transplant Congress

    Alternations in Amplitude of Low Frequency Fluctuation in Renal Allograft Recipients That Received Tacrolimus or Sirolimus: An fMRI Study.

    J. Wen,1 X. Ni,1 L. Wu,2 G. Zheng,2 L. Zhang,2 J. Chen.1

    1National Clinical Research Center of Kidney Diseases, Jinling Hospital, Medical School of Nanjing University, Nanjing, China; 2Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China

    Objective The side-effects of resting tremor was common in renal transplant receipts receive tacrolimus. But the mechanism of this side-effect was unknown. This study want…
  • 2017 American Transplant Congress

    Immunosuppressant Costs for Medicare Part D and Kidney Transplant Recipients Since the Introduction of Generic Formulations in an Incident Kidney Transplant Population.

    M. Helmuth,1 M. Turenne,1 J. Park,2 Q. Liu,1 M. Oguntimein,3 S. Dutcher,3 R. Balkrishnan,4 J. Zee,1 A. Smith,1 A. Leichtman.1

    1Arbor Research Collaborative for Health, Ann Arbor, MI; 2U of Michigan, Ann Arbor, MI; 3Food and Drug Administration, Silver Spring, MD; 4U of Virginia, Charlottesville, VA

    Background: Substitution of generics (GEN) for brand name (BN) immunosuppressants (IS) has increased in kidney transplant recipients (KTR) since the introduction of GEN mycophenolate mofetil…
  • 2017 American Transplant Congress

    Understanding the Role of Induction Agents in Older versus Younger Kidney Transplant Recipients.

    Q. Huang, F. Ammary, M. McAdams-DeMarco, D. Segev.

    Johns Hopkins University, Baltimore, MD

    Background: There has been an increase in the number of older (over 65) KT recipients. Aging-related changes such as differences in immune senescence may influence…
  • 2017 American Transplant Congress

    Using Basiliximab Does Not Increase De Novo DSA Incidence but Reduces Cytomegalovirus Infections and Neoplastic Complications in Non-Sensitized Kidney Transplant Patients.

    M. Marron-Wojewodzki,1 I. Szwarc,1 C. Rene,2 J.-F. Eliaou,2 G. Mourad,1 M. Le Quintrec.1,3

    1Department of Nephrology, Dialysis and Transplantation, Hôpital Lapeyronie, Montpellier University Hospital, Montpellier, France; 2Departement of Immunology, Hôpital Saint Eloi, Montpellier University Hospital, Montpellier, France; 3Inserm U1183, IRMB, Hôpital Saint Eloi, Montpellier University Hospital, Montpellier, France

    Background. In kidney transplantation, de novo donor specific antibodies (dnDSA) are associated with antibody-mediated rejection (AMR) and graft failure. After dnDSA development, 24% of the…
  • 2017 American Transplant Congress

    Endoscopic Therapy of Bile Duct Strictures After Liver Transplant.

    H. Woller, P. Mantry, A. Mejia, S. Cheng, C. Fasola.

    Gastroenterolgy and Hepatology, Methodist Dallas Medical Center, Dallas, TX

    Background and Aims: Common Bile Duct Strictures (CBDS) are a significant source of morbidity after liver transplantation (LT) We report our outcomes of endoscopic treatment…
  • 2017 American Transplant Congress

    Extending the Limit for Living Donor Liver Transplantation: Similar Outcomes After Left vs. Right Lobe Graft, a Propensity Score Analysis.

    T. Wong, K. Ng, J. Fung, K. Chok, A. Chan, C. Lo.

    Surgery, The University of Hong Kong, Hong Kong, Hong Kong

    BackgroundThis study aimed to investigate the impact of graft selection (left vs. right lobe) in LDLT.MethodThis was a retrospective study that included all patients who…
  • 2017 American Transplant Congress

    Kinetics of Liver regeneration in Donors After Living Donor Living Transplant.

    S. Sable, S. Maheshwari, R. Jadhav, K. Yadav, S. Sharma, S. Kumar, A. Chouhan, S. Kapoor, V. Varma, V. Kumaran.

    Liver Transplant & HPB, Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India

    Introduction:The fundamental principle in LDLT lies in the fact that it should provide enough liver volume with a safe remnant.The main pretext for safe donor…
  • 2017 American Transplant Congress

    Long-Term Analysis of Combined Liver-Lung Transplant Outcomes at a Single-Center.

    K. Freischlag,1 B. Ezekian,2 M. Mulvihill,2 S. Knechtle.2

    1School of Medicine, Duke University, Durham, NC; 2Surgery, Duke University, Durham, NC

    Purpose: Combined liver-lung transplantation (CLLT) is indicated in patients who would not be expected to survive transplantation of either organ alone. We present one of…
  • 2017 American Transplant Congress

    Use of Biodegradable Stents for the Treatment of Anastomotic Biliary Strictures in Pediatric Liver Transplant Patients.

    J. Quintero,1 J. Juamperez,1 V. Cabello,1 M. Perez,3 I. Bilbao,2 J. Molino,1 R. Charco.2

    1Pediatric Liver Transplant Unit, Hospital Vall d'Hebron, Barcelona, Catalunya, Spain; 2HPB Surgery and Transplants Department, Hospital Vall d'Hebron, Barcelona, Catalunya, Spain; 3Interventional Radiologist Department, Hospital de La Vall d'Hebron, Barcelona, Catalunya, Spain

    Objectives To evaluate feasibility, safety and mid-time outcome of pediatric liver transplant patients treated with a biodegradable biliary stent for anastomotic biliary strictures.Methods Retrospective study…
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