ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Pre-Donation Weight Loss Postpones Living Kidney Donation without Attaining the Desired Weight Maintenance in the Midterm.

    P. Ventura-Aguiar, E. De Sousa-Amorim, J. Campistol, F. Diekmann, F. Oppenheimer, I. Revuelta.

    Renal Transplant Unit, Hospital Clinic, Barcelona, Spain.

    Pre-donation weight loss in living kidney donation has two main objectives: reduce surgical risk, and decrease long-term complications from obesity and glomerular hypertrophy secondary to…
  • 2016 American Transplant Congress

    MicroRNAs in Urinary Sediments as Non-Invasive Tool to Detect Acute Rejection After Kidney Transplantation.

    E. Gielis,1,2 J. Anholts,2 H. de Fijter,3 I. Bajema,4 F. Claas,2 M. Eikmans.2

    1Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium; 2Immunohematology, LUMC, Leiden, Netherlands; 3Nephrology, LUMC, Leiden, Netherlands; 4Pathology, LUMC, Leiden, Netherlands.

    MicroRNAs in urine are suitable targets for non-invasive detection of acute rejection (AR), since they represent relatively stable analytes. Indeed, we found that PCR signals…
  • 2016 American Transplant Congress

    Influence of AKIN Stage on the Outcome of Deceased Donor Kidney Transplantation (DDKTx).

    I. Qaqish, D. Haakinson, K. Reddy, M. Smith, H. Khamash, H. Raymond.

    Mayo Clinic, Phoenix, AZ.

    BackgroundTransplanting kidneys from donors with AKI is one of the methods to minimize the disparity between numbers of listed patient and donor pool. Our aim…
  • 2016 American Transplant Congress

    No Significant Impact of KAS on Prior Living Kidney Donors' Access to Timely Transplant of High Quality Kidneys.

    J. Wainright,1 A. Kucheryavaya,1 M. Aeder,2 D. Klassen,1 D. Stewart.1

    1UNOS, Richmond, VA; 2UH Case MC, Cleveland, OH.

    BackgroundPrior living donors (PLDs) who develop ESRD post-donation have received priority on the kidney (KI) waiting list (WL) since 9/2/96. The new Kidney Allocation System…
  • 2016 American Transplant Congress

    Complications of Dual Antiplatelet Therapy Among Recipients of Kidney Transplants.

    F. Weng, A. Athavale, K. Hussain, K. Tibaldi, G. Rogal.

    Saint Barnabas Medical Center, Livingston, NJ.

    Introduction: For patients undergoing percutanous coronary intervention (PCI) with drug-eluting stents, dual antiplatelet therapy (DAPT) is often used to prevent stent thrombosis. Kidney transplantation of…
  • 2016 American Transplant Congress

    Gene Expression Microarray Analysis of Purified CD16-Stimulated Human NK Cells and Indication Biopsies Supports a CD16-Mediated Role for NK Cells in Antibody-Mediated Kidney Rejection.

    M. Parkes,1 P. Halloran,1 L. Hidalgo.2

    1Dept. of Medicine, University of Alberta, Edmonton, AB, Canada; 2Dept. of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.

    BACKGROUND: CD16α mediates NK cell responses to donor-specific IgG antibodies (DSA), and shares mechanisms with effector T cell receptor (TCR) stimulation. Whether CD16α-inducible transcripts are…
  • 2016 American Transplant Congress

    Utilizing HLA Single Antigen Flow Beads Assays to Evaluate Anti-MAMU Antibody in Sensitized Nonhuman Primate Model.

    J. Kwun,1 C. Burghuber,2 M. Manook,1 A. Clark,3 D. Chen,3 S. Knechtle.1

    1Surgery, Duke University, Durham; 2Surgery, Medical University of Vienna, Vienna, Austria; 3Pathology, Duke University, Durham.

    [Background] Non-human primate models of sensitization provide great preclinical models to investigate the mechanisms of antibody-mediated rejection or desensitization. Now there a growing interest on…
  • 2016 American Transplant Congress

    Ex Vivo Expansion of Human Alloantigen-Reactive Regulatory T Cells Using Monocyte-Derived Dendritic Cells versus CD40L-Stimulated B Cells.

    H. Zhang,1 Y. Zhao,1 L. Lu,1 Q. Tang,2 M. Ezzelarab,1 A. Thomson.1

    1Thomas E. Starzl Transplantation Institute Department of Surgery, University of Pittsburgh school of medicine, Pittsburgh, PA; 2Department of Surgery, UCSF, San Francisco, CA.

    Background:Alloantigen-reactive murine and human CD4+CD25+FOXP3+ regulatory T cells (arTreg) are more potent in promoting long-term allograft survival than polyclonal Treg in experimental models. Dendritic cells…
  • 2016 American Transplant Congress

    Center Volume Is Associated with Outcome Following Pancreas Transplantation within the Eurotransplant Region.

    W. Kopp,1,2 M. van Meel,2 H. Putter,3 U. Samuel,2 H. Arbogast,4 W. Schareck,5 J. Ringers,1 A. Braat.1

    1Surgery, Leiden University Medical Center, Leiden, Netherlands; 2Eurotransplant International Foundation, Leiden, Netherlands; 3Medical Statistics, Leiden University Medical Center, Leiden, Netherlands; 4General, Visceral, Transplant, Vascular and Thoracic Surgery, University of Munich – Grosshadern Medical Centre, Munich, Germany; 5University Medical Center Rostock, Rostock, Germany.

    Introduction Outcome following all kinds of surgery depends on several factors, amongst these the annual volume-outcome relationship. This might also be the case in a…
  • 2016 American Transplant Congress

    Plasma Alemtuzumab Levels Show Great Interpatient Variability, but Are Not Associated with Late Acute Rejection in Simultaneous Pancreas-Kidney Recipients.

    J. Bank,1 M. Mallat,1 C. Jol-van der Zijde,2 R. Bredius,2 P. van der Boog,1 A. Braat,3 J. Ringers,3 M. Reinders,1 J. de Fijter.1

    1Nephrology, LUMC, Leiden, Netherlands; 2Pediatrics, LUMC, Leiden, Netherlands; 3Surgery, LUMC, Leiden, Netherlands.

    Introduction: Alemtuzumab induction followed by a steroid-free, tacrolimus (Tac) and mycophenolate mofetil (MMF) based regimen effectively prevented acute rejection after simultaneous pancreas-kidney transplantation (SPKT). Acute…
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