2016 American Transplant Congress
Profiling Metabolic Differences Between Graft- vs. Pathogen-Elicited CD8+ T Cell Responses.
The challenge of immune modulation in transplantation is to inhibit pathologic alloreactivity while minimizing off-target toxicities and preserving protective immunity. Data have emerged demonstrating the…2016 American Transplant Congress
Factors and Outcomes Associated with Daptomycin Non-Susceptible Enterococcal Infections in Solid Organ Transplant Recipients.
Background: Daptomycin non-susceptible enterococcal (DNSE) infections are associated with poor outcomes. Information regarding factors and outcomes of DNSE in solid organ transplant (SOT) recipients (SOTR)…2016 American Transplant Congress
Experience Using a Discharge Calculator for Discharge Planning Post Liver Transplantation (OLT).
Cleveland Clinic, Cleveland, OH.
We previously developed and validated a nomogram to predict discharge disposition post OLT. The current study analyzes our experience using the discharge calculator.Patients &Methods:We retrospectively…2016 American Transplant Congress
Matrix Metalloproteinase-9 in Human Orthotopic Liver Transplant Biopsies.
The Dumont-UCLA Transplant Center, Los Angeles.
Liver ischemia reperfusion injury (IRI) is an inflammatory event that contributes to graft dysfunction in orthotopic liver transplantation (OLT). Matrix Metalloproteinases (MMPs) are responsible for…2016 American Transplant Congress
Pre-Transplant IgM to Post-Transplant IgG DSA Conversion May Be Affected by Immunosuppression.
1Terasaki Foundation Laboratory, Los Angeles, CA; 2East Carolina University, Greenville, NC.
Post-transplant (tx) IgG donor-specific antibodies (DSA), but not IgM DSA has been identified as one of the major causes of late graft loss. Considering the…2016 American Transplant Congress
Racial Disparities in Perioperative Complications After Live Kidney Donation.
Background: The frequency and severity of perioperative complications after contemporary live kidney donation are not well-described.Methods: We integrated national U.S. live donor registry data with…2016 American Transplant Congress
The Use of Sofosbuvir (SOF)-Containing Direct Antiviral Agents (DAA)-Based Regimens Requires Increase in Tacrolimus (Tac) Doses in Kidney Transplant (KT) Recipients with Hepatitis C Virus (HCV) Infection.
Background: The use of SOF-containing regimens based on NS5A inhibitors has not been shown interactions with Tac in liver transplant.Specific data on KT recipients are…2016 American Transplant Congress
Distinct Phenotype and Function of Plasmacytoid Dendritic Cells from Kidney Allografts in Tolerant Recipients.
BACKGROUND: Cellular infiltrates in kidney allografts may be relevant to the induction or maintenance of regulatory tolerance. Here we examined the phenotype, anatomical distribution and…2016 American Transplant Congress
Non-Human Primate Lung Allograft Survival Is Prolonged by IL-6 Inhibition and ATG Treatment Possibly Through Expansion of Peripheral Regulatory T Cells.
Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
BACKGROUND: Inflammatory responses have been linked to the development of acute and chronic rejection after lung transplantation in various models. Previous studies have demonstrated that…2016 American Transplant Congress
Rituximab Induction in Cardiac Transplantation Is Associated with Accelerated Coronary Artery Vasculopathy: CTOT11.
On Behalf of the CTOT11 Consortium, Brigham & Women's Hospital, Boston, MA.
PurposeThe NIH-funded study CTOT11: Prevention of Cardiac Allograft Vasculopathy Using Rituximab (RIT) Therapy in Cardiac Transplantation, was a randomized clinical trial in non-sensitized primary heart…
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