Am J Transplant, Volume 16, Suppl 3 Archives - Page 69 of 180 - ATC Abstracts

2016 American Transplant Congress
Acute Kidney Injury (AKI) Associated with Chronic Kidney Disease (CKD) in Paediatric Non-Kidney Transplant Recipients.
C. Williams,^1,2 K. Borges,² T. Banh,² J. Vasilevska-Ristovska,² R. Chanchlani,^1,2 V. Ng,^1,2 A. Dipchand,^1,2 M. Solomon,^1,2 D. Hebert,^1,2 S. Kim,^1,3 B. Astor,⁴ R. Parekh.^1,2,3
¹University of Toronto, Toronto, Canada; ²Hospital for Sick Children, Toronto, Canada; ³University Health Network, Toronto, Canada; ⁴University of Wisconsin, Madison.
Background: Kidney dysfunction is common after solid organ transplantation; however, rates of post-transplant AKI and CKD in children are unknown.Objective: Determine rates of AKI and…
2016 American Transplant Congress
Controlled Oxygenated Rewarming and Subnormothermic Machine Perfusion of Steatotic Livers: First Clinical Results.
D. Hoyer,¹ A. Gallinat,¹ J. Treckmann,¹ T. Benkoe,¹ S. Swoboda,¹ U. Rauen,² A. Paul,¹ T. Minor.¹
¹General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; ²Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany.
IntroductionControlled oxygenated rewarming (COR) of cold stored livers by machine perfusion demonstrated convincing results in the first clinical pilot series (1). Here we report on…
2016 American Transplant Congress
Proteoforms: Novel Biomarkers for Acute Rejection in Liver Transplant Recipients.
J. Levitsky,¹ T. Toby,¹ K. Kim,¹ I. Ntai,¹ A. Demetris,² M. Abecassis,¹ P. Thomas,¹ N. Kelleher.¹
¹Northwestern, Chicago; ²UPMC, Pittsburgh.
Background: Biomarker profiles diagnostic of acute rejection (AR) in liver transplant (LT) recipients could enhance the diagnosis and management of recipients. Our aim was to…
2016 American Transplant Congress
Enhanced Activation of Hemostasis During Kidney Transplantation in Patients on Dialysis Compared to Pre-Emptively Transplanted Patients.
T. van den berg, G. Nieuwenhuijs-Moeke, S. Bakker, R. Pol, T. Lisman.
Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands.
Introduction: It is generally assumed that dialysis patients (DP) have a more severe bleeding diathesis related to platelet dysfunction than pre-emptively transplanted patients (PEP) who…
2016 American Transplant Congress
Antithymocyte Globulin (ATG) versus Anti-interleukin-2 Receptor (Anti-IL-2R) as Induction Therapy for Kidney Transplantation After a Nonrenal Transplant.
H. Mai,¹ K. Trébern-Launay,¹ C. Legendre,² M. Kessler,³ L. Rostaing,⁴ V. Garrigue,⁵ E. Morelon,⁶ S. Brouard,¹ M. Giral,¹ J.-P. Soulillou.¹
¹Service de Néphrologie et Transplantation, INSERM UMR 1064, CHU de Nantes, Nantes, France; ²Hôpital Necker, Paris, France; ³CHU de Nancy, Nancy, France; ⁴CHU de Toulouse, Toulouse, France; ⁵CHU de Montpellier, Montpellier, France; ⁶CHU de Lyon, Lyon, France.
Patients undergoing kidney transplant after a previous nonrenal organ transplant (NRT) present a small but emerging subpopulation of kidney transplant recipients. Little is known about…
2016 American Transplant Congress
C5a Induces CSF1-Dependent Regulatory Macrophage (Mreg) Development Required for Murine Allograft Tolerance.
I. Llaudo, P. Conde, J. Ochando, P. Heeger.
Icahn School of Medicine at Mount Sinai, New York, NY.
Anti-CD40L (MR1) induced heart transplant tolerance has been recently shown to be dependent on early post-transplant intragraft accumulation of CD11b+Ly6CLoLy6G- DC-SIGN expressing Mreg that develop…
2016 American Transplant Congress
Delayed Induction of Mixed Chimerism Permits Kidney-Induced Cardiac Allograft Tolerance to be Applied to Recipients of Cadaveric Organs.
M. Tonsho,¹ G. Benichou,¹ R. Yu,¹ S. Boskovic,¹ R. Colvin,^1,2 E. Farkash,² R.-N. Smith,² J. Allan,^1,4 A. Cosimi,¹ T. Kawai,^1,3 J. Madsen.^1,4
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA; ³Department of Surgery, Massachusetts General Hospital, Boston, MA; ⁴Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA.
(BACKGROUND)Cardiac tolerance in nonhuman primates (NHPs) has been induced for the first time by kidney co-transplantation in combination with donor bone marrow infusion when the…
2016 American Transplant Congress
Avoidance of CNI and Steroids Using Belatacept – A Preliminary Report of CTOT-16.
R. Mannon,¹ P. Stock,² A. Mehta,³ D. Ikle,⁴ N. Watson,⁵ N. Bridges,⁵ M. Robien,⁵ K. Newell.³
¹UAB, Birmingham; ²UCSF, San Francisco; ³Emory, Atlanta; ⁴Rho, Chapel Hill; ⁵NIAID, Bethesda.
CTOT-16 tested the hypothesis that belatacept used as maintenance immunosuppression (IS) in kidney transplantation would allow the long-term avoidance of CNI and corticosteroids. Methods: Primary…
2016 American Transplant Congress
Where Are the KDPI 0-20% Kidneys Going in the New KAS? A Major Allocation Shift.
M. Aeder,¹ N. Turgeon,² A. Kucheryavaya,³ D. Stewart.³
¹Univ Hosp Case Med Ctr, Cleveland, OH; ²Emory Univ, Atlanta, GA; ³UNOS, Richmond, VA.
The introduction of KAS in December 2014 marked an effort to incorporate a longevity metrics into deceased organ allocation by prioritizing retrieved kidneys with the…
2016 American Transplant Congress
Blockade of HLA Antibody-Triggered Classical Complement Activation by High-Affinity Humanized Monoclonal Anti-C1s Antibody TNT009 – Results of a First-in-Human Phase 1 Trial.
J. Mühbacher,¹ B. Jilma,² M. Wahrmann,³ L. Marinova,³ F. Eskandary,³ J. Gilbert,⁴ S. Panicker,⁴ G. Böhmig.³
¹Department of Surgery, Medical University of Vienna, Vienna, Austria; ²Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; ³Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria; ⁴True North Therapeutics, Inc., South San Francisco, CA.
Study purpose: Classical complement may play a key role in ABMR. A promising therapeutic approach could be complement inhibition at the level of key component…