2016 American Transplant Congress
Relationship Between Mean Fluorescence Intensity and C1q/C3d-Fixing Capacities of Anti-HLA Antibodies.
The capacity of anti-HLA antibodies (Abs) to activate complement is thought to be an informative property susceptible to facilitate outcome prediction. Two different tests, C1q-…2016 American Transplant Congress
DSA After Transplant Increases Risk of Renal Allograft Failure Independent of Concurrent Biopsy Results: The DEKAF Study Data.
Donor-specific HLA antibodies (DSA) are a major cause of renal allograft dysfunction and loss following transplant. The presence of DSA, with or without C4d deposition,…2016 American Transplant Congress
The Effect of Donor Age on Acute Rejection Age – The Clinical Impact of Donor Immuno-Senescence in the Modern Immunosuppressive Era.
Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom.
Experimental work has shown that donor age may alter the immune response of the recipient so that older donor grafts elicit a stronger response in…2016 American Transplant Congress
IFTA Is Linked to Urinary Microbiome Changes.
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
Purpose: The microbiome is important to human health and alteration may lead to aberrant immunity and disease. Interstitial fibrosis and tubular atrophy(IFTA) occurs in 20%…2016 American Transplant Congress
The Relationship Between Kidney Donor Profile Index and Six Month eGFR in Deceased Donor Recipients.
Division of Nephrology, University of Virginia, Charlottesville, VA.
Kidney function, as measured by GFR, at 6 months post-kidney transplant is a powerful predictor of long-term post-transplant outcomes. This study sought to understand the…2016 American Transplant Congress
Pre-Existing Chronic Heart Failure in Kidney Transplantation: An Underestimated Risk Factor for Graft Loss?
Nephrology, Charité University, Berlin, Germany.
BACKGROUND: Cardio-renal interactions influence graft and patient survival in kidney transplant recipients (KTR). There is only few data available analyzing pre-existing chronic heart failure (CHF)…2016 American Transplant Congress
The mTORC2 Activation Is Critical for Hepato-Cytoprotection Against Ischemia and Reperfusion Injury.
Background & AimsRapamycin and Everolimus have been used in liver transplant patients, particularly those with calcineurin inhibitor-related nephrotoxicity and hepatocellular carcinoma. Although designed as mTORC1…2016 American Transplant Congress
Alloantibody Suppression by Bruton Tyrosine Kinase Antagonist Ibrutinib Is Associated with a Moderate Splenic B-Cell Reduction.
Comprehensive Transplantation Center/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Bruton tyrosine kinase (Btk) is specifically required for activation of the B-cell antigen receptor signaling pathway that contributes to the initiation and maintenance of…2016 American Transplant Congress
CXCL12 as Innovative Immune Isolating Chemokine for Microencapsulated Allo and Xeno-Transplantation in NHPs.
Introduction The purpose of this study is to determine whether a clinical-grade alginate-microencapsulant incorporating CXCL12, can protect and sustain the function of allo and/or adult…2016 American Transplant Congress
Indirect Allo-Antigen Stimulation Identifies the Presence of Either Regulatory IL-10 or of Effector Cytokines IFN-g, IL-21, IL-17a Production by Human Blood Allo-Reactive Memory TFH and TCONV CD4+ T Cells.
Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA.
Background: It is well accepted that human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. While our previous analysis showed…
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