Am J Transplant, Volume 16, Suppl 3 Archives - Page 53 of 180 - ATC Abstracts

2016 American Transplant Congress
Impact of C3d and C1q-Binding DSA Detected Long-Term After Kidney Transplantation.
M. Crespo,^1,2 D. Redondo,^1,2 C. Garcia,³ J. Gimeno,⁴ M. Perez,^1,2 M. Mir,¹ J. Hernandez,³ J. Yelamos,² A. Faura,^1,2 J. Pascual.^1,2
¹Nephrology and Transplant, Hospital del Mar, Barcelona, Spain; ²Medical Research Institute (IMIM), Hospital del Mar, Barcelona, Spain; ³Catalunya Reference Laboratory, Barcelona, Spain; ⁴Pathology, Hospital del Mar, Barcelona, Spain.
HLA DSA detected after kidney transplantation(KT) correlate with outcome, but not all are equal and produce the same functional consequences. Early complement-binding DSA were asssociated…
2016 American Transplant Congress
Elevation of Peripheral IL-6 in Kidney Transplant Recipients with Antibody Mediated Rejection.
N. Wilson, A. Djamali, R. Redfield.
University of Wisconsin, Madison.
Background: Despite current therapy, antibody mediated rejection (AMR) remains a major cause of kidney allograft loss. IL-6 is a known survival factor of antibody secreting…
2016 American Transplant Congress
Mechanisms of Cellular Repopulation within Healthy or Intrinsically Scarred Kidney Extracellular Matrix Scaffolds.
J. Uzarski,¹ C. Deaton,⁵ H. Ward,² A. Wandinger-Ness,³ W. Miller,⁴ J. Wertheim.¹
¹Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; ²Department of Internal Medicine, University of New Mexico HSC, Albuquerque, NM; ³Department of Pathology, University of New Mexico HSC, Albuquerque, NM; ⁴Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL; ⁵Department of Biology, University of Mexico, Albuquerque, NM.
Background: While the number of wait-listed patients suffering from kidney failure continues to rise, the number of kidney transplants performed each year has remained stagnant.…
2016 American Transplant Congress
Monocyte Recruitment to HLA Class I Antibody-Activated Endothelial Cells Is Dependent Upon mTOR.
S. Salehi, E. Reed.
Pathology & Laboratory Medicine, UCLA, Los Angeles, CA.
Aim: Antibody-mediated rejection (AMR) is a major issue affecting solid organ transplants, manifesting with recruitment of monocytes to the endothelium of the allograft. The purpose…
2016 American Transplant Congress
Everolimus Abrogates C5a and TGFβ Mediated Perycite-to-Myofibroblast Transition (PMT) Inhibiting Vascular Rarefaction.
G. Castellano, R. Franzin, A. Stasi, C. Divella, L. Gesualdo.
Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Microvascular pericytes have detrimental effects on tubulo-interstitial fibrosis via PMT. However, therapeutic strategies that might interfere with this process are currently lacking. We aimed to…
2016 American Transplant Congress
Late-Onset Pneumocystis Jirovecii Pneumonia After Renal Transplantation: A Case-Control Study.
J. Lee,¹ J. Lee,¹ S. Song,¹ J. Lee,¹ S.-K. Kwon,¹ B. Kim,² M. Kim,¹ S. Kim,¹ Y. Kim,¹ K. Huh.¹
¹Surgery, Yonsei University College of Medicine, Seoul, Korea; ²Internal Medicine (Nephrology), Yonsei University College of Medicine, Seoul, Korea.
BackgroundPneumocystis jirovecii pneumonia (PCP) usually occurs during the first year after solid organ transplantation. Introduction of routine prophylaxis have reduced the incidence of PCP drastically.…
2016 American Transplant Congress
Risk Factors for Early vs. Late Onset Clostridium difficile Infection(CDI) in Solid Organ Transplant Recipients (SOTR).
Y. Natori, M. Shiotsuka, L. Oen, E. Renner, L. Singer, H. Ross, D. Kumar, C. Rotstein, A. Humar, S. Husain.
Multi-Organ Transplant, University Health Network, Toronto, ON, Canada.
Introduction: CDI is one of the most common infections among SOTR, and is associated with significant morbidity and mortality. However, the data regarding early vs.…
2016 American Transplant Congress
Storage Kidneys Prior to Transplantation Using First Polish Preservation Solution "Biolasol" – Preliminary Report.
A. Jozwik,¹ P. Domagala,¹ R. Kieszek,¹ M. Wszola,¹ M. Bieniasz,¹ M. Serwanska-Swietek,¹ M. Durlik,² F. Ryszka,³ A. Chmura,¹ A. Kwiatkowski.¹
¹Department of General Surgery and Transplantology, Medical University of Warsaw, Warsaw, Poland; ²Departments of Transplantology and Nephrology, Medical University of Warsaw, Warsaw, Poland; ³BIOCHEFA, Sosnowiec, Poland.
One of the factors affecting function of the transplanted organ is a method of its storage. The aim of the study is to evaluate the…
2016 American Transplant Congress
Incidence of Infectious Disease and Malignancies After Rituximab Therapy in Kidney-Transplant Recipients.
E. Schrezenmeier,¹ T. Doerner,² O. Staeck,¹ K. Budde,¹ F. Halleck.¹
¹Nephrology, Charité, Berin, Germany; ²Rheumatology, Charité, Berlin, Germany.
BACKGROUND:Rituximab off-label use is common in solid organ transplantation. It is used in patients with antibody-mediated rejections, in AB0-incompatible renal transplantation, in pre-sensitized organ recipients…
2016 American Transplant Congress
The Effect of Bortezomib on DSA Reduction During the Treatment of AMR in Pediatric Kidney Transplant Patients.
O. Moussa, S. Self, K. Twombley.
Medical University of South Carolina, Charleston, SC.
Introduction: The optimal therapy for AMR is not well defined in children or adults. AMR carries a worse prognosis than ACR and can lead to…